Acute mixture toxicity of halogenated chemicals and their next generation counterparts on zebrafish embryos

Godfrey, Amy; Abdelmoneim, Ahmed; Sepúlveda, Marı́a S.

doi:10.1016/j.chemosphere.2017.04.146

Cited by 45 publications

(15 citation statements)

References 15 publications

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“…6893‐02‐3; Sigma‐Aldrich) was also used as a reference control. Test solutions were prepared following the methods described by Godfrey, Abdel‐Moneim and Sepulveda () and contained the same amount of Replenish (Seachem Laboratories Inc.; 12.5 mL/1 L of Reverse Osmosis (RO) water) with pH adjusted to neutral (7.0‐7.5).…”

Section: Methodsmentioning

confidence: 99%

Sex‐specific endocrine‐disrupting effects of three halogenated chemicals in Japanese medaka

Godfrey

Hooser

Abdelmoneim

et al. 2019

J of Applied Toxicology

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Several halogenated chemicals are found in an array of products that can cause endocrine disruption. Human studies have shown that endocrine responses are sex specific, with females more likely to develop hypothyroidism and males more likely to have reproductive impairment. The objective of this study was to assess sex differences on thyroid and estrogenic effects after exposure of Japanese medaka (Oryzias latipes, SK2MC) to halogenated compounds. This strain is an excellent model for these studies as sex can be determined non-destructively a few hours postfertilization. Medaka embryos were exposed to sublethal concentrations of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP, 0.019 mg/L), perfluorooctanoic acid (PFOA, 4.7 mg/L) and its next generation alternative, perfluorobutyric acid (PFBA, 137 mg/L). Methimazole (inhibits thyroid hormone synthesis) and the thyroid hormone triiodothyronine served as reference controls. Fish were exposed throughout embryo development until 10 days postfertilization. Females displayed significantly larger swim bladders (which are under thyroid hormone control) after exposure to all chemicals with the exception of triiodothyronine, which caused the opposite effect. Females exposed to TDCPP and PFOA had increased expression of vitellogenin and exposure to PFOA upregulated expression of multiple thyroidrelated genes. Upregulation of estrogenic-regulated genes after exposure to TDCPP, PFOA and methimazole was only observed in males. Overall, our results suggest that females and males show an estrogenic response when exposed to these halogenated chemicals and that females appear more susceptible to thyroid-induced swim bladder dysfunction compared with males. These results further confirm the importance of considering sex effects when assessing the toxicity of endocrine-disrupting compounds.

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Section: Methodsmentioning

confidence: 99%

Sex‐specific endocrine‐disrupting effects of three halogenated chemicals in Japanese medaka

Godfrey

Hooser

Abdelmoneim

et al. 2019

J of Applied Toxicology

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“…The exposure to a variety of chemicals is known as the "cocktail effect" and expresses the way in which different chemicals are released from different sources and affect humans [7,21]. Individual chemicals can become more dangerous when mixed together and act as an aggravating factor [22].…”

Section: Engineering Steels and High Entropy-alloysmentioning

confidence: 99%

Multicomponent Alloys for Biomedical Applications

Reclaru¹,

Ardelean²,

Grecu³

et al. 2020

Engineering Steels and High Entropy-Alloys

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Titanium alloys are considered to be the most advanced materials for orthopedic implants due to the favorable combination of mechanical properties, low density, tissue tolerance, high strength-to-weight ratio, good resistance to corrosion by body fluids, biocompatibility, low density, nonmagnetic properties, and the ability to join with the bone. This is the reason why we decided to assess the resistance of two titanium alloys currently used for orthopedic implants, namely, Ti6Al7Nb and Ti6Al4V, as reference, to cyclic fatigue by dynamic tests with crevice corrosion stimulation. According to the results obtained, the examined electrochemical quantities, the visual and SEM observations, and EDX analysis reveal better corrosion behavior of the prostheses made of Ti6Al4V-anodized series compared to prostheses made of Ti6Al7Nb. The further comparison of two explanted proximal modules, made of Ti6Al7Nb and Ti6Al4V, to the same type of prostheses evaluated by cyclic fatigue dynamic tests with crevice corrosion stimulation reveals that there are significant similarities, in particular with regard to the electrolyte diffusion, deposition of products and corrosion. Cation extraction tests which were carried out for Ti6Al7Nb prostheses that have undergone particular surface treatments show significant differences depending on the surface treatment and demonstrate that orthopedic implant materials are not "inert."

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“…Different chemicals from different sources, released at different times and from different places can expose humans to a mixture of chemicals, inducing the ‘cocktail effect’. The way chemicals are released from different sources on the one hand, and how they combine to give rise to human exposure with adverse effects on the other hand, has to be understood [9,10]. An aggravating factor is that individual chemicals can become more dangerous when mixed with other chemicals, the ‘cocktail effect’.…”

Section: Introductionmentioning

confidence: 99%

Corrosion Resistance of Stainless Steels Intended to Come into Direct or Prolonged Contact with the Skin

Ziegenhagen¹,

Reclaru

Ardelean

et al. 2019

Materials

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The biocompatibility of materials in contact with a living tissue becomes a puzzle in the overall picture of assessing the toxic effects of chemicals that come into contact with us. Allergic reactions to substances are a significant and growing health problem affecting large parts of the population in Europe. Wristwatches are objects worn in prolonged contact with the skin, being subject to localized corrosion, especially pitting and crevice types, in sulfide-chloride medium, and high wear in the bracelets joints. Watches of medium quality are usually made of stainless steels. The X2 CrNiMo 17-12-2 316L grade as well as X1 CrNiMo 20-25-5 Cu 1 or 904L are commonly used, having good resistance to generalized corrosion. The passive layer is nevertheless insufficient to ensure complete immunity in all cases of localized corrosion encountered during wear. For this reason, a high-corrosion-resistant steel: X1 CrNiMo 18-15-4 N 0.15 or 317LMN, from three different suppliers was evaluated. Metallographic characterization was carried out. The corrosion behavior evaluation was performed for the generalized corrosion, pitting and crevice corrosion and galvanic corrosion. Galvanic couples steel 317LMN-gold 18K alloy 3N and gold 18K 5M were used. The results of the generalized and pitting corrosion test indicated three basic groups. All of the 317LMNs were similar. The 316L variants tested noticeably worse. The 904Ls were difficult to discern, but certainly easier than the 316Ls and, possibly, at least comparable to the 317LMNs.

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Acute mixture toxicity of halogenated chemicals and their next generation counterparts on zebrafish embryos

Cited by 45 publications

References 15 publications

Sex‐specific endocrine‐disrupting effects of three halogenated chemicals in Japanese medaka

Sex‐specific endocrine‐disrupting effects of three halogenated chemicals in Japanese medaka

Multicomponent Alloys for Biomedical Applications

Corrosion Resistance of Stainless Steels Intended to Come into Direct or Prolonged Contact with the Skin

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