Acute Mesenteric Ischemia

Lendzion, Rebecca; Frahm-Jensen, Gert; Keck, James

doi:10.1055/s-0042-1743283

Cited by 6 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the group of patients who are hemodynamically unstable, usually as a result of septic shock or in cases where the use of laparoscopic techniques would be associated with a significantly prolonged or postponed procedure, laparotomy access should be considered first [ 54 ]. In a situation where revascularization is necessary, conversion and continuation of the procedure from the classic access are required [ 55 ].…”

Section: Acute Mesenteric Ischemiamentioning

confidence: 99%

The Association of Polish Surgeons (APS) clinical guidelines for the use of laparoscopy in the management of abdominal emergencies. Part II.

Sobocki¹,

Pędziwiatr²,

Bigda³

et al. 2023

Videosurgery and Other Miniinvasive Techniques

View full text Add to dashboard Cite

Introduction Over the past three decades, almost every type of abdominal surgery has been performed and refined using the laparoscopic technique. Surgeons are applying it for more procedures, which not so long ago were performed only in the classical way. The position of laparoscopic surgery is therefore well established, and in many operations it is currently the recommended and dominant method. Aim The aim of the preparation of these guidelines was to concisely summarize the current knowledge on laparoscopy in acute abdominal diseases for the purposes of the continuous training of surgeons and to create a reference for opinions. Material and methods The development of these recommendations is based on a review of the available literature from the PubMed, Medline, EMBASE and Cochrane Library databases from 1985 to 2022, with particular emphasis on systematic reviews and clinical recommendations of recognized scientific societies. The recommendations were formulated in a directive form and evaluated by a group of experts using the Delphi method. Results and conclusions There are 63 recommendations divided into 12 sections: diagnostic laparoscopy, perforated ulcer, acute pancreatitis, incarcerated hernia, acute cholecystitis, acute appendicitis, acute mesenteric ischemia, abdominal trauma, bowel obstruction, diverticulitis, laparoscopy in pregnancy, and postoperative complications requiring emergency surgery. Each recommendation was supported by scientific evidence and supplemented with expert comments. The guidelines were created on the initiative of the Videosurgery Chapter of the Association of Polish Surgeons and are recommended by the national consultant in the field of general surgery. The second part of the guidelines covers sections 6 to12 and the following challenges for surgical practice: acute appendicitis, acute mesenteric ischemia, abdominal injuries, bowel obstruction, diverticulitis, laparoscopy in pregnancy and postoperative complications requiring a reoperation.

show abstract

Section: Acute Mesenteric Ischemiamentioning

confidence: 99%

The Association of Polish Surgeons (APS) clinical guidelines for the use of laparoscopy in the management of abdominal emergencies. Part II.

Sobocki¹,

Pędziwiatr²,

Bigda³

et al. 2023

Videosurgery and Other Miniinvasive Techniques

View full text Add to dashboard Cite

show abstract

“…Um dos maiores obstáculos no cuidado da IMA reside Brazilian Journal of Health Review, Curitiba, v. 7, n. 1, p. 3447-3454, jan./fev., 2024 no diagnóstico precoce, considerando que o exame físico é pouco específico. No entanto, a combinação de uma suspeita clínica robusta com a utilização adequada de técnicas de imagem aumenta a probabilidade de o paciente receber o tratamento apropriado, que pode incluir a revascularização mesentérica, a ressecção intestinal e outras abordagens, a depender da etiologia relacionada e da condição geral do paciente (SAKAMOTO et al, 2021;LENDZION;FRAHM-JENSEN;KECK, 2022;GARZELLI et al, 2023).…”

Section: Introductionunclassified

Isquemia mesentérica aguda - etiologia esquecida de abdome agudo cirúrgico

Carneiro,

Amorim,

Souza

et al. 2024

Braz. J. Hea. Rev.

View full text Add to dashboard Cite

A Isquemia Mesentérica Aguda (IMA) é uma condição rara e potencialmente grave que resulta na súbita falta de irrigação sanguínea para o intestino delgado, causando dor abdominal intensa e podendo levar a complicações sérias, como peritonite e sepse. A etiologia da IMA varia, com embolia arterial mesentérica, trombose arterial mesentérica, isquemia mesentérica não oclusiva e trombose venosa mesentérica sendo causas comuns. A prevalência aumenta com a idade, principalmente acima da sétima década, e a incidência varia entre diferentes regiões. Outrossim, o diagnóstico precoce é desafiador - devido à natureza inespecífica dos sintomas e à baixa incidência da doença - e é frequentemente alcançado por meio de tomografia computadorizada com contraste, auxiliada por uma suspeita clínica robusta. Os sintomas podem variar dependendo da etiologia, destacando-se a dor abdominal como sintoma comum. O exame físico geralmente é pouco específico, e a abordagem diagnóstica deve incluir avaliação laboratorial, como biomarcadores específicos. Ademais, o tratamento da IMA depende da etiologia e condição do paciente. Opções incluem revascularização mesentérica, ressecção intestinal e intervenções endovasculares. Estudos recentes sugerem que abordagens endovasculares podem ter resultados mais favoráveis em comparação com intervenções cirúrgicas abertas, com menor mortalidade e necessidade de ressecção intestinal. Nesse sentido, a escolha da terapia deve considerar fatores como estabilidade hemodinâmica, presença de sinais de peritonite e a extensão do comprometimento intestinal. A sobrevida em 5 anos após o tratamento endovascular foi relatada como superior em comparação com a cirurgia vascular aberta. Diferentes técnicas de restauração do fluxo sanguíneo são aplicadas com base na etiologia da IMA, destacando-se a embolectomia, angioplastia e procedimentos de bypass.

show abstract

“…Ischemia/reperfusion (I/R) damage of the intestine is induced by a wide range of clinical diseases, including small bowel obstruction, mesenteric artery thrombosis, hemorrhagic shock, and sepsis (1)(2)(3). Intestinal I/R injury results in substantial damage to intestinal epithelial cells and mucosal barrier function.…”

Section: Introductionmentioning

confidence: 99%

miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2

Jia,

Wang,

Gao

et al. 2023

Shock

View full text Add to dashboard Cite

Gut barrier dysfunction caused by intestinal ischemia/reperfusion (I/R) injury is associated with substantial death and morbidity. In this research, the role of microRNAs (miRNAs) in regulating intestinal I/R injury was investigated. We used miRNA sequencing to analyze clinical ischemic and normal intestinal samples. Through bioinformatics analysis based on sequencing results, we found that upregulated miRNAs inhibited epithelial barrier function and cell proliferation, with miR-379-5p being the most significantly upregulated in the ischemic intestine. Further studies confirmed the role of miR-379-5p through experiments in the human ischemic intestine, the mouse I/R injury model in vivo, and cell hypoxia/reoxygenation models in vitro. Inhibiting miR-379-5p increased epithelial cell proliferation and improved barrier function after I/R injury. We also identified eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) as a downstream target gene of miR-379-5p through bioinformatics prediction and experimental verification. The findings suggest that inhibiting miR-379-5p could improve intestinal epithelial cell proliferation and barrier function by targeting EIF4G2. The goal of this study was to find a potential target for treating I/R injury in the intestine, as well as to prevent and mitigate the damage caused.

show abstract

Acute Mesenteric Ischemia

Cited by 6 publications

References 48 publications

The Association of Polish Surgeons (APS) clinical guidelines for the use of laparoscopy in the management of abdominal emergencies. Part II.

The Association of Polish Surgeons (APS) clinical guidelines for the use of laparoscopy in the management of abdominal emergencies. Part II.

Isquemia mesentérica aguda - etiologia esquecida de abdome agudo cirúrgico

miR-379-5P INHIBITION ENHANCES INTESTINAL EPITHELIAL PROLIFERATION AND BARRIER FUNCTION RECOVERY AFTER ISCHEMIA/REPERFUSION BY TARGETING EIF4G2

Contact Info

Product

Resources

About