Acute meningoencephalitis in a patient with systemic lupus erythematosus

Abstract

This case alerts to the need of careful examination of patients with SLE, collection of adequate cultures and evaluation of predisposition towards infections, before the introduction of immunosuppressants due to potentially fatal infection.

Multiple brain abscesses due to Listeria monocytogenes infection in a patient with systemic lupus erythematosus: A case report and literature review

“…4,5 Central nervous system (CNS) infections are rare bacterial complications of SLE, but can be a significant cause of mortality. 6 Here, we report a case of Listeria monocytogenes-associated multiple brain abscesses in a patient with SLE.…”

“…[8][9][10][11] To the best of our knowledge, since Dr Schulze et al 12 reported the first case of a patient with disseminated SLE who died due to L. monocytogenes infection in 1953, 52 cases have been reported in the English-language literature (Table 2). [4][5][6][7] Meningoencephalitis is the most common manifestation in patients with SLE who develop L. monocytogenes infections; other cases with neurolisteriosis. 9,34 As few as 6 cases have been reported, with 4 involving multiple brain abscesses (Table 3).…”

“…However, in the case series we reviewed, the proportions of patients with active and inactive SLE who developed L. monocytogenes infections were similar. Final diagnosis typically requires a comprehensive assessment based on the results of laboratory and imaging examinations.Another challenge for the treatment of SLE with L. monocytogenes infection is that serious infections can trigger the development or exacerbation of SLE 6. During a severe infection, basic treatment is very important to achieve a positive outcome.…”