Acute macular neuroretinopathy following Pfizer-BioNTech COVID-19 vaccination

Valenzuela, Daniel A.; Groth, Sylvia L.; Taubenslag, Kenneth J.

doi:10.1016/j.ajoc.2021.101200

Cited by 35 publications

(28 citation statements)

References 5 publications

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“…Near-infrared imaging and OCT imaging confirmed a diagnosis of bilateral AMN. Valenzuela et al described a similar report of bilateral AMN following vaccination with the second dose BNT162b2 vaccine [93]. In contrast to other reports, the authors reported resolution of symptoms after 7 days with observation only.…”

Section: Acute Macular Neuroretinopathymentioning

confidence: 88%

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

et al. 2022

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Vaccination efforts as a mitigation strategy in the corona virus disease 2019 (COVID-19) pandemic are fully underway. A vital component of understanding the optimal clinical use of these vaccines is a thorough investigation of adverse events following vaccination. To date, some limited reports and reviews have discussed ocular adverse events following COVID-19 vaccination, but a systematic review detailing these reports with manifestations and clinical courses as well as proposed mechanisms has yet to be published. This comprehensive review one-year into vaccination efforts against COVID-19 is meant to furnish sound understanding for ophthalmologists and primary care physicians based on the existing body of clinical data. We discuss manifestations categorized into one of the following: eyelid, orbit, uveitis, retina, vascular, neuro-ophthalmology, ocular motility disorders, and other.

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Section: Acute Macular Neuroretinopathymentioning

confidence: 88%

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

et al. 2022

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“…Cases of AMN after COVID vaccination and influenza vaccination were recently reported and strengthen a possible association between AMN and vaccination. 5 , 8 , 9 , 10 , 11 , 12 Although the pathogenesis of AMN remains uncertain and complex, a retinal microvascular etiology affecting the deep retinal capillary plexus (DCP) is suggested. 6 , 8 It is plausible that relative hypovolemia associated with fever and flu-like illness post-vaccination or possibly subclinical small deep retinal capillary vasculitis leading to ischemia of the DCP.…”

Section: Discussionmentioning

confidence: 99%

Bilateral acute macular neuroretinopathy in a young woman after the first dose of Oxford–AstraZeneca COVID-19 vaccine

Gabrielle

Baudin

Ghezala

et al. 2022

American Journal of Ophthalmology Case Reports

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Purpose To report a case of bilateral acute macular neuroretinopathy following the first dose of Oxford-AstraZeneca COVID-19 (coronavirus disease 2019) vaccine in a young, Caucasian, and healthy woman. Observations A 25-year-old Caucasian female patient presented to the ophthalmology department of Dijon University Hospital with a 3-week history of black spots and paracentral scotoma in both eyes. She had no past medical history and was using the combined estrogen-progestin oral contraceptive (COC). These symptoms occurred 24 h after receiving the first Oxford-AstraZeneca COVID-19 vaccination dose. The ophthalmologic signs were preceded a few hours earlier by fever and flu-like symptoms. Ophthalmologic examination revealed a preserved visual acuity with a quiet anterior segment and normal fundus in both eyes. Findings on multimodal retinal imaging, particularly near-infrared reflectance (NIR) and optical coherence tomography (OCT) imaging, were classical of an acute macular neuroretinopathy in both eyes. Conclusions and importance: COVID-19 vaccination is justified as an essential public health measure. Acute macular neuroretinopathy may occur in patient receiving a COVID-19 vaccination dose. Further reports are needed to confirm this association. Physicians should be aware of this complication and request an eye examination with at least OCT or NIR imaging in the case of any visual symptoms after vaccination, notably in young women using COC.

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“…All subjects received the AZD1222 vaccine. In another case report, Valenzuela et al reported a case of a young female subject who presented with bilateral scotoma and photopsia 48 h after receiving the second dose of the BNT162b2 vaccine [ 46 ]. The subject was using an etonogestrel/ethinyl estradiol 0.12–0.015 mg/24 h vaginal ring for birth control.…”

Section: Covid-19 Vaccine-associated Ocular Inflammationmentioning

confidence: 99%

The Eye of the Storm: COVID-19 Vaccination and the Eye

Betzler

Ng³

et al. 2021

Ophthalmol Ther

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The COVID-19 pandemic has galvanized the global response towards the development of new vaccines based on novel technologies at an unprecedented pace. Since the widespread implementation of vaccination campaigns, case reports on vaccines' systemic side effects, including ocular manifestations, have emerged. Since administered vaccines are generally not able to cause the disease in the recipient, or induce an immune response against the pathogen, we hypothesize that the development of ocular phenomena post-COVID-19 vaccination may occur via an immune response elicited by the vaccine. Of many, the most common ocular adverse events include facial nerve palsy, central venous sinus thrombosis and acute anterior uveitis. These COVID-19 vaccine-induced ocular (CVIO) adverse events could resemble the ocular findings in some of the COVID-19 patients. This review will provide a comprehensive overview of published ocular side effects potentially associated with COVID-19 vaccination and serve as a springboard for further research into CVIO adverse events.

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Acute macular neuroretinopathy following Pfizer-BioNTech COVID-19 vaccination

Cited by 35 publications

References 5 publications

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

Bilateral acute macular neuroretinopathy in a young woman after the first dose of Oxford–AstraZeneca COVID-19 vaccine

The Eye of the Storm: COVID-19 Vaccination and the Eye

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