Acute Macular Neuroretinopathy following Coronavirus Disease 2019 Vaccination

Mambretti, Manuela; Huemer, Josef; Torregrossa, Giulia; Ullrich, Marlies; Findl, Oliver; Casalino, Giuseppe

doi:10.1080/09273948.2021.1946567

Cited by 57 publications

(39 citation statements)

References 19 publications

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“…Treatment was not reported. A pair of unilateral AMN cases were likewise reported in women aged 22 and 28 two days following the AZD1222 vaccine by Mambretti et al [88]. Chen et al reported a similar case with similar exam findings in a 21-year-old woman who developed paracentral scotomas three days after receiving her first dose of the BNT162b2 vaccine [89].…”

Section: Acute Macular Neuroretinopathymentioning

confidence: 64%

“…Mambretti et al proposed in their reports of AMN that the pro-inflammatory state following COVID-19 vaccination may have had a compounding effect on the pro-thrombotic effects of oral contraceptives [88]. Furthermore, they proposed that hypovolemia associated with the inflammatory reaction following vaccination may have led to reduced blood flow in the DCP.…”

Section: Mechanismsmentioning

confidence: 99%

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Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

et al. 2022

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Vaccination efforts as a mitigation strategy in the corona virus disease 2019 (COVID-19) pandemic are fully underway. A vital component of understanding the optimal clinical use of these vaccines is a thorough investigation of adverse events following vaccination. To date, some limited reports and reviews have discussed ocular adverse events following COVID-19 vaccination, but a systematic review detailing these reports with manifestations and clinical courses as well as proposed mechanisms has yet to be published. This comprehensive review one-year into vaccination efforts against COVID-19 is meant to furnish sound understanding for ophthalmologists and primary care physicians based on the existing body of clinical data. We discuss manifestations categorized into one of the following: eyelid, orbit, uveitis, retina, vascular, neuro-ophthalmology, ocular motility disorders, and other.

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Section: Acute Macular Neuroretinopathymentioning

confidence: 64%

Section: Mechanismsmentioning

confidence: 99%

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

et al. 2022

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“…Cases of AMN after COVID vaccination and influenza vaccination were recently reported and strengthen a possible association between AMN and vaccination. 5 , 8 , 9 , 10 , 11 , 12 Although the pathogenesis of AMN remains uncertain and complex, a retinal microvascular etiology affecting the deep retinal capillary plexus (DCP) is suggested. 6 , 8 It is plausible that relative hypovolemia associated with fever and flu-like illness post-vaccination or possibly subclinical small deep retinal capillary vasculitis leading to ischemia of the DCP.…”

Section: Discussionmentioning

confidence: 99%

Bilateral acute macular neuroretinopathy in a young woman after the first dose of Oxford–AstraZeneca COVID-19 vaccine

Gabrielle

Baudin

Ghezala

et al. 2022

American Journal of Ophthalmology Case Reports

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Purpose To report a case of bilateral acute macular neuroretinopathy following the first dose of Oxford-AstraZeneca COVID-19 (coronavirus disease 2019) vaccine in a young, Caucasian, and healthy woman. Observations A 25-year-old Caucasian female patient presented to the ophthalmology department of Dijon University Hospital with a 3-week history of black spots and paracentral scotoma in both eyes. She had no past medical history and was using the combined estrogen-progestin oral contraceptive (COC). These symptoms occurred 24 h after receiving the first Oxford-AstraZeneca COVID-19 vaccination dose. The ophthalmologic signs were preceded a few hours earlier by fever and flu-like symptoms. Ophthalmologic examination revealed a preserved visual acuity with a quiet anterior segment and normal fundus in both eyes. Findings on multimodal retinal imaging, particularly near-infrared reflectance (NIR) and optical coherence tomography (OCT) imaging, were classical of an acute macular neuroretinopathy in both eyes. Conclusions and importance: COVID-19 vaccination is justified as an essential public health measure. Acute macular neuroretinopathy may occur in patient receiving a COVID-19 vaccination dose. Further reports are needed to confirm this association. Physicians should be aware of this complication and request an eye examination with at least OCT or NIR imaging in the case of any visual symptoms after vaccination, notably in young women using COC.

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“…Mambretti et al reported a 22-year-old female and a 28-year-old female who were on long-term oral contraceptives they developed acute onset of paracentral scotoma two days after receiving the ChAdO×1 COVID-19 vaccine. Multimodal retinal imaging was consistent with AMN in both cases [17].…”

mentioning

confidence: 65%

Ocular Manifestations after Receiving COVID-19 Vaccine: A Systematic Review

Lee

Huang

2021

Vaccines

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The coronavirus disease 2019 (COVID-19) pandemic has had profound and lasting consequences since 2019. Although vaccines against COVID-19 have been developed and approved under emergency use authorization, various adverse events have also been reported after COVID-19 vaccination. This review was undertaken to help clinicians recognize the possible manifestations and systemic pathogenesis, especially those related to the eye, after receiving COVID-19 vaccination. A systemic search was performed on 22 August 2021 through Embase, Medline, and Cochrane Library for publications on ocular manifestations after COVID-19 vaccination. Two case-control studies/retrospective cohort studies, one cross-sectional study, three case series, sixteen case reports, two images, and seven letters were included. Ocular manifestations after receiving COVID-19 vaccines may appear on the eyelid, cornea and ocular surface, retina, uvea, nerve, and vessel. The ocular manifestations occurred up to forty-two days after vaccination, and vaccine-induced immunologic responses may be responsible. Although the incidence rate of ocular symptoms is considerably lower in the vaccinated subjects than in COVID-19 patients, physicians should be aware of the possible associations between COVID-19 vaccines and ocular symptoms for the early diagnosis and treatment of vision problems or life-threatening complications.

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Acute Macular Neuroretinopathy following Coronavirus Disease 2019 Vaccination

Cited by 57 publications

References 19 publications

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

Bilateral acute macular neuroretinopathy in a young woman after the first dose of Oxford–AstraZeneca COVID-19 vaccine

Ocular Manifestations after Receiving COVID-19 Vaccine: A Systematic Review

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