Acute lymphocytic leukemia mimicking spondyloarthritis in an adolescent: A case report and review of the literature

Xu, Danyi; Xu, Guanhua; Xu, Liqin; Xu, Bei; Chen, Weiqian; Sun, Cheng; Yue, Lihuan; Lin, Jin

doi:10.3892/ol.2015.4026

Cited by 7 publications

(4 citation statements)

References 11 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Paraneoplastic musculoskeletal syndromes are rare diseases caused by malignancies through mechanisms other than tumour mass effect or metastatic infiltration (see table 1). Paraneoplastic sacroiliitis is a rare clinical entity with only nine cases previously described in the literature, all associated with haematological malignancies, including five cases of acute lymphoblastic leukaemia,2–6 two cases of acute myeloid leukaemia,7 8 and one case each of lymphocytic lymphoma,9 and chronic myelomonocytic leukaemia 10. The median age at presentation was 40 years (range 17–64) with a female-to-male ratio of 2:1 and the duration of low back pain ranged from 1 month to 1 year.…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic sacroiliitis

Arad,

Werren,

White

2023

BMJ Case Rep

View full text Add to dashboard Cite

A man in his early 70s presented with stiffness and aching in the shoulder and pelvic girdles. His C reactive protein level was elevated at 116 mg/L, leading to an initial diagnosis of polymyalgia rheumatica. Treatment with prednisone at 20 mg/day provided limited improvement and relapses recurred despite concomitant immunosuppressive agents. Extensive investigations failed to reveal an underlying aetiology.Five years later, gross painless haematuria led to the detection of an invasive papillary urothelial carcinoma. A review of the staging CT scan revealed findings compatible with bilateral erosive sacroiliitis, which had developed since his initial presentation. Radical cystoprostatectomy provided temporary relief but after a further 9 months, symptoms relapsed, and metastatic spread was discovered.Paraneoplastic sacroiliitis is a rare clinical entity; and to the best of our knowledge, this is the first reported case associated with a solid tumour.

show abstract

Section: Discussionmentioning

confidence: 99%

Paraneoplastic sacroiliitis

Arad,

Werren,

White

2023

BMJ Case Rep

View full text Add to dashboard Cite

show abstract

“…A B sacroilitis como forma de presentación de LLA [6][7][8][9] . Además, se encuentran dos casos reportados en pacientes con leucemia mieloide aguda 10,11 .…”

Section: Discussionunclassified

Sacroilitis paraneoplásica: presentación inusual de leucemia linfoblástica aguda

Solís

Flores‐Padilla

2020

CIRU

View full text Add to dashboard Cite

La sacroilitis es una manifestación poco común de neoplasias hematológicas. Reportamos el caso de una mujer de 40 años que presentó un cuadro de 1 mes de evolución con fiebre y sacroilitis simulando espondiloartritis, acompañado de anemia, hepatomegalia y elevación de marcadores inflamatorios. El abordaje descartó infecciones y causas inflamatorias de dolor sacroilíaco. Los hallazgos en la médula ósea llevaron al diagnóstico de leucemia linfoblástica aguda (LLA) de células B. Hasta donde sabemos, el presente es uno de los pocos casos publicados de LLA que se manifiesta con sacroilitis. La sacroilitis como manifestación inicial de LLA puede resultar en un diagnóstico erróneo, por lo que el diagnóstico diferencial es esencial cuando se encuentran presentes características atípicas.

show abstract

“…Hoshino et al (12) and Mondal et al (13) have reported one case each of AML who presented initially as sacroiliitis. Xu et al (14) have reported a case of ALL in an adolescent male who presented with sacroiliitis mimicking spondyloarthritis. The patient had atypical features, such as splenomegaly, anemia, neutropenia, monocytosis, and thrombocytopenia with poor treatment response to NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

Rheumatic manifestations as initial presentation of malignancy: A case series from a tertiary care center in India

et al. 2019

View full text Add to dashboard Cite

Objective Malignant neoplasms can be associated with a wide variety of rheumatological manifestations that may be caused by direct tumor invasion into bones and joints, as a paraneoplastic syndrome, and through altered immune surveillance. To identify the relationship between rheumatic manifestations in various malignancies. Methods Twenty patients with various malignancies presenting with rheumatic conditions in our tertiary medical care were studied retrospectively from case records at the Kalinga Institute of Medical Sciences from 2013 to 2018. Results In the present study, total of 20 patients including 12 males and 8 females with mean age at diagnosis of was 46.3±22.2 years with various malignancy associated rheumatic diseases were included. In total 20% of patients with were current smokers. Seven (35%) had hematological malignancies whereas 13 (65%) had solid malignancies. Most common presenting feature was arthritis (40%), followed by weight loss (20%), skin rash (10%), fever (15%) and muscle weakness (10%) at the time of diagnosis. All of them developed malignancy within 24 months of diagnosis. Among the autoantibodies, only 6 patients (30%) were positive for both ANA (n= 4, 20%) and RF (n=2, 10%), other antibodies were negative. The patients in the hematological malignancies had significantly higher serum levels of LDH, Mean±SD U/L compared to solid malignancy group (716.8±169.6 vs. 249.9±161.6, p<0.001). Conclusion In our cohort, all the patients developed malignancies within 2 years of diagnosis of rheumatic condition. Higher serum LDH levels helpful to differentiates between hematological and solid malignancies. Hence early detection of malignancy is of major importance in these patients.

show abstract

Acute lymphocytic leukemia mimicking spondyloarthritis in an adolescent: A case report and review of the literature

Cited by 7 publications

References 11 publications

Paraneoplastic sacroiliitis

Paraneoplastic sacroiliitis

Sacroilitis paraneoplásica: presentación inusual de leucemia linfoblástica aguda

Rheumatic manifestations as initial presentation of malignancy: A case series from a tertiary care center in India

Contact Info

Product

Resources

About