Acute lymphoblastic leukemia with maturation–a new entity with clinical significance

Abstract

The diagnosis of 'ALL with maturation' (ALLm) is proposed. One hundred and one patients with untreated ALL were entered into this study. The diagnosis of ALLm was made when more than 20% of all nucleated elements in the bone marrow

Adult acute lymphoblastic leukaemia

“…The subgroup L3 gives a hint of the presence of B-lineage ALL (B-ALL), but again this distinction is not absolute, since occasional B-ALLs display L1/L2 morphology and, conversely, L3-like morphology can be seen in acute non-lymphocytic leukaemia. Rarer morphological variants (see Section 2.2) are "hand-mirror" cell ALL, ALL associated with hypereosinophilia, granulated ALL and ALL with mature cells that are nearly indistinguishable from mature lymphoid neoplasms and require expert observers for accurate identification [15]. The role of cytochemistry (see Section 2.2) is limited to differentiating ALL from myeloid leukaemias.…”