Acute Lymphoblastic Leukemia and Acute Lymphoblastic Lymphoma: Same Disease Spectrum but Two Distinct Diagnoses

Kline, Kathryn A. F.; Kallen, Michael E.; Duong, Vu H.; Law, Jennie Y.

doi:10.1007/s11899-021-00648-y

Cited by 9 publications

(11 citation statements)

References 95 publications

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“…8 While pediatric B-LLy and B-ALL were assumed to be on the spectrum of the same disease, newer data are highlighting biological differences between the 2 entities. 3,[9][10][11] Studies describing the cytogenetics of B-LLy are rare. Several reports comparing B-LLy and B-ALL have highlighted some similarities and differences between the 2 diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports comparing B-LLy and B-ALL have highlighted some similarities and differences between the 2 diseases. 3,[9][10][11][12] (Table 3) Recurrent cytogenetic abnormalities, particularly unfavorable ones, are more commonly seen in B-ALL. 9 But both diseases share a similar incidence of deletions in genes of B-cell development and hyperdiploidy.…”

Section: Discussionmentioning

confidence: 99%

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B-Lymphoblastic Lymphoma in Children: A Case Series From a Single Institution

Devine,

Trivedi,

Reilly

2024

Journal of Pediatric Hematology/Oncology

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Background: Pediatric B-lymphoblastic lymphoma is an uncommon subtype of non-Hodgkin lymphoma. Studies regarding the biology, clinical course, and approach to relapse are limited. Observations: We present a series of children with B-lymphoblastic lymphoma to describe the clinical course at diagnosis and relapse as well as the role of tumor cytogenetics, immunotherapy, and hematopoietic stem cell transplant. Conclusions: The prognostic significance of cytogenetic changes in B-lymphoblastic lymphoma is not well described but may offer improved risk stratification. Immunotherapy may offer salvage options for relapsed disease and can serve as a bridge to transplant.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

B-Lymphoblastic Lymphoma in Children: A Case Series From a Single Institution

Devine,

Trivedi,

Reilly

2024

Journal of Pediatric Hematology/Oncology

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“…The cytological examination of pericardial fluid was negative, but its flow cytometric analysis was consistent with T-LBL. A skin biopsy showed an infiltration of T lymphocytes 1) [3][4][5][6][7][8][9] . Patients were young and predominantly male, and most had a mediastinal mass.…”

Section: Case Reportmentioning

confidence: 99%

“…This research had no funding sources. Erdoğan et al 2012 5 Kapur et al 2014 6 Ozdemir et al 2015 7 Alimi et al 2020 8 Sablak et al 2021 9…”

Section: Conflict Of Interestmentioning

confidence: 99%

Taponamiento cardiaco como forma de presentación inicial de un linfoma linfoblástico de células T

Belokopytova-Chakh¹,

Ruiz-González²,

Vilardell³

et al. 2022

Gal. Clin.

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We report a 27-year-old man who presented with cardiac tamponade and was eventually diagnosed of T-cell lymphoblastic lymphoma (T-LBL) by the flow cytometric analysis of pericardial fluid. Despite pericardiocentesis and institution of standard chemotherapy, the patient developed malignant arrhythmia with hemodynamic instability, and died soon after admission. Cardiac tamponade is rarely the first manifestation of a T-LBL.

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“…According to clinical statistics, leukemia accounts for 4% and 3% of oncological diseases in males and females, respectively, with mortality rates of 4% and 3%, respectively (1). The incidence of B-cell ALL (B-ALL) accounts for 85% and 75% of ALL cases in children and adults, respectively (2). Recently,…”

Section: Introductionmentioning

confidence: 99%

Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia

Chang¹,

Feng²,

Liao³

et al. 2023

Transl Cancer Res

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Background: Myocyte enhancer factor 2D (MEF2D) is involved in the progression of various malignant tumors. However, its impact on B-cell acute lymphoblastic leukemia (B-ALL) has not been elucidated. Methods: In this study, the expression level of MEF2D in B-ALL patients was validated through the Gene Expression Omnibus (GEO) database and clinical specimens. MEF2D-knockdown B-ALL cell lines were constructed by lentivirus transfection, and the effects of MEF2D on the viability, apoptosis, cycle progression, and drug sensitivity of B-ALL cells were verified by Cell Counting Kit-8 (CCK-8) and flow cytometry (FCM). The effect of MEF2D on the proliferation of B-ALL cells in vivo was verified via the construction of a xenograft mouse model. The mechanism of MEF2D regulating B-ALL cells was explored by RNA sequencing analysis, quantitative reverse transcription polymerase chain reaction (qRT-PCR), western blotting, and immunohistochemical (IHC). Results: In this study, overexpression of MEF2D was observed in B-ALL patients and was remarkably correlated to disease progression in ALL patients. The knockdown of MEF2D expression suppressed cell viability, induced cell apoptosis, blockaded cell cycle progression, enhanced drug sensitivity of B-ALL cells in vitro, and reduced the tumor load in vivo. Furthermore, mechanistic studies revealed that MEF2D knockdown downregulated the expression of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)protein kinase B (AKT) signaling pathway.Conclusions: Our research demonstrated that MEF2D was markedly expressed in B-ALL. MEF2D knockdown inhibited cancer progression of B-ALL both in vitro and in vivo, which may be related to the downregulation of the PI3K-AKT signaling pathway. The data suggest that MEF2D plays a vital role in the process of tumorigenesis and may be a potential novel target for B-ALL therapy.

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Acute Lymphoblastic Leukemia and Acute Lymphoblastic Lymphoma: Same Disease Spectrum but Two Distinct Diagnoses

Cited by 9 publications

References 95 publications

B-Lymphoblastic Lymphoma in Children: A Case Series From a Single Institution

B-Lymphoblastic Lymphoma in Children: A Case Series From a Single Institution

Taponamiento cardiaco como forma de presentación inicial de un linfoma linfoblástico de células T

Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia

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