Acute lupus peritonitis successfully treated with steroid pulse therapy

Andoh, Akira; Fujiyama, Yoshihide; Kitamura, Shizuka; Ihara, Takashi; Ueda, Katsumoto; Miyagawa, Akiko; Hodohara, Keiko; Inoue, Hisayuki; Bamba, Tadao

doi:10.1007/bf02934116

Cited by 19 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, low complements and raised double stranded DNA antibodies in the ascitic uid of a patient with lupus peritonitis has also been described. 23 CT features of GI tract vasculitis have been well described and include ascites with peritoneal enhancement, bowel wall thickening with focal or diffuse dilated bowel loops and prominence of mesenteric vessels with palisade pattern or comb like appearance. 24,25 Despite the likelihood that most of our patients had symptoms secondary to SLE involvement of the gut or peritoneum, their outcome was generally good.…”

Section: Discussionmentioning

confidence: 99%

Reversible acute gastrointestinal syndrome associated with active systemic lupus erythematosus in patients admitted to hospital

et al. 2003

Lupus

View full text Add to dashboard Cite

Patients with systemic lupus erythematosus (SLE) frequently have gastrointestinal (GI) symptoms. These are usually self-limiting and related to treatment side-effects or concurrent illness. However, abdominal pain may be due to bowel ischaemia which can lead to infarction and perforation. The likelihood of these serious events is increased in individuals with pain severe enough to require assessment in hospital or a SLEDAI score > 5. This paper describes a group of patients with active SLE and GI symptoms severe enough to require admission to hospital using a retrospective review of 52 SLE patients admitted to hospital with acute abdominal symptoms. The results showed that abdominal pain (87%), vomiting (82%) and diarrhoea (67%) had been present for a mean of 4.4 +/- 6.5 days and SLEDAI score was > or = 4 in 83% of patients. CT scanning showed evidence of serositis and bowel involvement in 63% of patients who underwent this investigation. Intravenous (iv) fluids were used in 87%, parenteral steroids in 90% and iv cyclophosphamide in 31%. Most (n = 51) were discharged well. Recurrence of GI symptoms occurred in 12 patients. The conclusions are that active SLE may manifest as an acute gastrointestinal syndrome. Early diagnosis, bowel rest, supportive medical therapy and treatment with corticosteroids and/or immunosupressives can result in a good outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

Reversible acute gastrointestinal syndrome associated with active systemic lupus erythematosus in patients admitted to hospital

et al. 2003

Lupus

View full text Add to dashboard Cite

show abstract

“…Acute lupus peritonitis was reported to occur during an acute generalized lupus flare [3,4]. In the present case, however, urinalysis was well controlled and no other clinical findings were found during the maintenance therapy of lupus nephritis.…”

Section: Dear Sirmentioning

confidence: 60%

“…Pathological examination showed subserosal and submucosal vasculitis in the patients with ascites due to lupus peritonitis [7]. Although steroid pulse therapy is considered to be effective in these conditions, the knowledge of efficacy of steroid pulse therapy in lupus peritonitis is limited [3,4]. Our case clearly demonstrated that steroid pulse therapy was useful in acute lupus peritonitis.…”

Section: Dear Sirmentioning

confidence: 82%

Acute Lupus Peritonitis during Treatment ofLupus Nephritis: Successful Treatment with Methylprednisolone Pulse Therapy

Uzu¹,

Chikamori²,

Yamato³

et al. 2000

Nephron

View full text Add to dashboard Cite

“…They are primarily related to vasculitis or to complications of therapy [1] [9]. The most common GI manifestations are abdominal pain with peritoneal signs, penetrating ulcers and transmural infarction [10] [11]. Also, endoscopic mucosal biopsies usually do not contain the vasculitic lesions.…”

Section: Resultsmentioning

confidence: 99%

Duodenitis in Systemic Autoimmune Diseases: Pathologist Perspective

Balasubramanian¹,

Badhe²,

Ganesh³

et al. 2018

OJRA

View full text Add to dashboard Cite

Aims: To study the histomorphology of duodenitis associated with systemic autoimmune diseases with clinicopathologic correlation. Patients and Methods: This is a descriptive prospective study. Fifteen patients of autoimmune diseases with duodenitis were included. Informed consent was taken. Histomorphological parameters studied were villous architecture, crypt architecture, intraepithelial lymphocyte (IEL) count per 100 enterocytes, villous tip IEL count per 20 enterocytes were counted, inflammatory cells in lamina propria-lymphocytes, neutrophils, eosinophils, epithelioid cells. Statistical analysis was done using IBM-SPSS software version 21. Results: Fifteen cases of duodenitis associated with autoimmune diseases included 6 patients of systemic lupus erythematosus (SLE), 5 of rheumatoid arthritis, one each of ankylosing spondylitis, systemic sclerosis, dermatomyositis and seronegative reactive arthritis. All these cases were serologically proven. Only 3 (20%) patients had mild villous blunting. Six patients (46.7%) had increased IEL counts. The range of IELs was 8-30, mean ± SD was 14 ± 7.6. Range of villous tip IELs was 0-8 with mean ± SD of 3.45 ± 2.56. Six patients (46.7%) had increased IEL counts but only 3 patients (20%) had increased villous tip IELs. All patients had moderate increase in lymphoplasmacytic infiltrate in lamina propria. Eosinophils in lamina propria were increased in 46.7% cases. Conclusion: One of the causes for malabsorptive conditions in adult population in South India is found to be duodenitis associated with autoimmune conditions. We conclude that a combination of clinical, serological, endoscopic and histopathologic features is crucial in arriving at a correct diagnosis.

show abstract

Acute lupus peritonitis successfully treated with steroid pulse therapy

Cited by 19 publications

References 11 publications

Reversible acute gastrointestinal syndrome associated with active systemic lupus erythematosus in patients admitted to hospital

Reversible acute gastrointestinal syndrome associated with active systemic lupus erythematosus in patients admitted to hospital

Acute Lupus Peritonitis during Treatment ofLupus Nephritis: Successful Treatment with Methylprednisolone Pulse Therapy

Duodenitis in Systemic Autoimmune Diseases: Pathologist Perspective

Contact Info

Product

Resources

About