Abstract:Efficient repair and regeneration of alveolar epithelium after acute lung injuries are critical for pulmonary maintenance. Previous studies suggested alveolar type II cells (ATIIs) are progenitors in the adult lung and Alveolar Type I cells (ATIs) are terminally differentiated. However, recent studies develop fresh perspectives, which suggest ATIs may play more roles. Here we show that ATIs exhibit markedly enhanced proliferation capacity and express a set of ATIIs associated genes after treated with damaged l… Show more
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