Acute lung injury and the acute respiratory distress syndrome in the injured patient

Bakowitz, Magdalena; Bruns, Brandon R.; McCunn, Maureen

doi:10.1186/1757-7241-20-54

Cited by 114 publications

(108 citation statements)

References 75 publications

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“…The present therapeutic approaches for ALI include supportive care, ventilator support, pharmacological treatments and mesenchymal stem cells (MSCs) [2, 7-9]. ALI can develop into more severe acute respiratory distress syndrome (ARDS) or multiple organ dysfunction syndrome (MODS), and the incidence and mortality of ALI remains high around the world [7, 10]. Therefore, developing novel therapies to treat ALI and improve the clinical outcomes is urgently necessary.…”

Section: Introductionmentioning

confidence: 99%

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Fibrocytes Ameliorate Acute Lung Injury by Decreasing Inflammatory Cytokine and Chemokine Levels and Reducing Neutrophil Accumulation in the Lung

Tai

Ding

et al. 2017

Cell Physiol Biochem

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Background/Aims: Acute lung injury (ALI) remains a severe disease that threatens human life around the world. To decrease the mortality of ALI and improve ALI treatment efficacy, the development of more ALI treatments is urgently needed. Whether fibrocytes directly participate in ALI has not been studied. Therefore, a mouse model of ALI was induced with lipopolysaccharide (LPS). Methods: Fibrocytes were harvested from peripheral blood mononuclear cells of bleomycin mice and identified by using flow cytometry to detect the expression of molecular makers. The fibrocytes were injected for the treatment of acute lung injury mice. The curative effects were evaluated by using ELISA to determine the cytokines (including TNF-α, IL-6 and IFN-γ) concentrations in bronchoalveolar lavage fluid (BALF) supernatant. Results: The concentrations of cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interferon-γ (IFN-γ) were increased in mice with ALI induced with LPS. The concentrations of TNF-α, IL-6, and IFN-γ as well as their mRNA and protein expression levels were decreased by administration of fibrocytes. The effect of fibrocytes in ameliorating ALI was time dependent. LPS treatment induced an increase in myeloperoxidase (MPO) activity, whereas the fibrocyte treatment caused inhibition of MPO activity as well as expression of the neutrophil-chemoattractant chemokine macrophage inflammatory protein 2 (MIP-2). Conclusion: Taken together, these data suggest that fibrocytes ameliorated ALI by suppressing inflammatory cytokines and chemokines as well as by decreasing the accumulation of neutrophils in the lung.

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Section: Introductionmentioning

confidence: 99%

“…Lipopolysaccharide (LPS) is a key component of the cell wall of gram-negative bacteria that can induce pulmonary and systemic infection [3, 10, 11]. LPS participates in initiating the inflammatory response by binding to its receptors.…”

Section: Introductionmentioning

confidence: 99%

Fibrocytes Ameliorate Acute Lung Injury by Decreasing Inflammatory Cytokine and Chemokine Levels and Reducing Neutrophil Accumulation in the Lung

Tai

Ding

et al. 2017

Cell Physiol Biochem

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“…According to Hudson et al, ARDS develops in 25% of patients with multiple injuries [11]. Bakowitz and all define trauma as the main predisposing condition in 7% cases of ARDS [2]. Recent USA multicenter randomized trials show the incidence of trauma-related ARDS to be 6.5% of traumatically injured patients [16,19].…”

Section: Discussionmentioning

confidence: 99%

Choice of Optimal Time and Type of Orthopedic Surgery in Multiple Injured Patients with Acute Respiratory Distress Syndrome (ARDS) Depending on Age: Retrospective Study

Stanislavovych¹,

Vasylivna²

2013

Ortop Traumatol Rehabil

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SUMMARYBackground. Multiple traumatic injuries are severe conditions with a high risk of complications. He morrhage, multiple organ failure syndrome (MOFS), systemic inflammatory response syndrome (SIRS) and sepsis are the most dangerous sequelae. ARDS (acute respiratory distress syndrome) is a part of MOFS. Despite new strategies of prevention and care, the mortality associated with these conditions still remains high.Materials and methods. We conducted a retrospective study of the surgical management tactic of 145 patients with multiple trauma complicated by ARDS. All patients were treated in Ivano-Frankivsk Regional Clinical Hospital between 2007 and 2012. There were 118 (81.4%) males and 27 (18.6%) females. Patients were divided into two age groups. Group I consisted of 113 (78%) patients aged 18-64 years, including 106 (94%) males and 7 (6%) females. Group II consisted of 32 (22%) patients over 65 years old, with 7 (21.8%) males and 25 (78.2%) females. AISS-NISS (Abbreviated Injury Severity Score -New Injury Severity Score) scores were 55.9±1.312 in Group I and 54.9±2.43 in Group II.Results. The difference in emergency surgery timing between Group І and ІІ was not significant (р>0.05). Age was an important criterion in defining optimal time of osteosynthesis (р<0.01). The choice of osteosynthesis type did not depend on patient age in the early period of trauma (1-3 days) (р>0.05), but the surgical tactic was significantly different in the late period (8 days and more) (р<0.01). Active fracture management with a stable osteosynthesis technique (intramedullary nailing, plating and external fixation) was preferred in the younger age group.Conclusions. 1. The age of the patient is quite an important factor defining the surgical tactic. 2. However, neither age nor severity of injury to the anatomical segments is a reliable criterion for assessing the severity of a patient's condition.

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“…We believe that TBI evokes pulmonary complications causing hypoxia in normoventilated patients. (18,19) The possible beneficial effect of early out-of-hospital intubation to secure the airway and to prevent hypoxia and aspiration has been questioned. Many studies have shown that a pre-hospital ETI in patients with TBI is associated with increased mortality.…”

Section: Discussionmentioning

confidence: 99%

Impact of pre-hospital oxygenation and ventilation status on outcome in patients with isolated severe traumatic brain injury

Strnad

Popovic

Lesjak

et al. 2014

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Introduction. Hypoxia is one of the secondary insults and it worsens the outcome in patients with severe traumatic brain injury (TBI). (CPC), and GCS score at discharge) when all six groups were compared together. We were unable to prove a deleterious effect of hypoxia or hyperoxia compared to normoxia on rate of survival to hospital discharge (STHD) (0.38 (0.52) vs 0.50 (0.51) vs 0.65 (0.49), f = 1.246, p = 0.298

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Acute lung injury and the acute respiratory distress syndrome in the injured patient

Cited by 114 publications

References 75 publications

Fibrocytes Ameliorate Acute Lung Injury by Decreasing Inflammatory Cytokine and Chemokine Levels and Reducing Neutrophil Accumulation in the Lung

Fibrocytes Ameliorate Acute Lung Injury by Decreasing Inflammatory Cytokine and Chemokine Levels and Reducing Neutrophil Accumulation in the Lung

Choice of Optimal Time and Type of Orthopedic Surgery in Multiple Injured Patients with Acute Respiratory Distress Syndrome (ARDS) Depending on Age: Retrospective Study

Impact of pre-hospital oxygenation and ventilation status on outcome in patients with isolated severe traumatic brain injury

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