Acute Lung Injury After Peppermint Oil Injection

Behrends, Matthias; Beiderlinden, Martin; J, Peters

doi:10.1213/01.ane.0000175774.33435.87

Cited by 11 publications

(10 citation statements)

References 7 publications

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“…Acute ingestion of peppermint oil resulted in coma [ 55 ], perhaps via neurological, hepatotoxic [ 54 ], or nephrotoxic [ 42 ] pathways prior to full recovery following intensive-care treatment. Acute intravenous injection of peppermint oil can cause pulmonary oedema and acute lung injury, due to direct toxicity and a resultant increase in pulmonary vascular permeability [ 9 ]. Chronic ingestion of menthol (non-specifically described as consuming “two bags” of menthol rich cough droplets; [10 mg] per droplet) has also been reported.…”

Section: Discussionmentioning

confidence: 99%

Menthol as an Ergogenic Aid for the Tokyo 2021 Olympic Games: An Expert-Led Consensus Statement Using the Modified Delphi Method

et al. 2020

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Introduction Menthol topical application and mouth rinsing are ergogenic in hot environments, improving performance and perception, with differing effects on body temperature regulation. Consequently, athletes and federations are beginning to explore the possible benefits to elite sport performance for the Tokyo 2021 Olympics, which will take place in hot (~ 31 °C), humid (70% RH) conditions. There is no clear consensus on safe and effective menthol use for athletes, practitioners, or researchers. The present study addressed this shortfall by producing expert-led consensus recommendations. Method Fourteen contributors were recruited following ethical approval. A three-step modified Delphi method was used for voting on 96 statements generated following literature consultation; 192 statements total (96/96 topical application/mouth rinsing). Round 1 contributors voted to “agree” or “disagree” with statements; 80% agreement was required to accept statements. In round 2, contributors voted to “support” or “change” their round 1 unaccepted statements, with knowledge of the extant voting from round 1. Round 3 contributors met to discuss voting against key remaining statements. Results Forty-seven statements reached consensus in round 1 (30/17 topical application/rinsing); 14 proved redundant. Six statements reached consensus in round 2 (2/4 topical application/rinsing); 116 statements proved redundant. Nine further statements were agreed in round 3 (6/3 topical application/rinsing) with caveats. Discussion Consensus was reached on 62 statements in total (38/24 topical application/rinsing), enabling the development of guidance on safe menthol administration, with a view to enhancing performance and perception in the heat without impairing body temperature regulation.

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Section: Discussionmentioning

confidence: 99%

Menthol as an Ergogenic Aid for the Tokyo 2021 Olympic Games: An Expert-Led Consensus Statement Using the Modified Delphi Method

et al. 2020

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“…Previous oil/fat-induced ARDS cases have reported mild to moderate respiratory affection. 5–7 Four cases have reported severe ARDS requiring mechanical ventilation 8–11 and one case multi-organ failure and death. 12 The pathophysiology is believed to be similar to fat embolism syndrome (FES), 13 characterized by an asymptomatic latent period of 12 to 72 hours, with subsequent development of dyspnea, tachypnea and hypoxemia.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal membrane oxygenation after intravenous injection of paraffin oil

2016

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We present a rare cause of acute respiratory distress syndrome (ARDS) due to an accidental intravascular injection of paraffin oil. While there is no specific therapy, we decided to support the patient with veno-venous extracorporeal membrane oxygenation (V-V ECMO) to allow the ARDS to resolve. A previously healthy 30-year-old man was admitted to the Emergency Department with acute onset respiratory distress following an injection with paraffin oil for cosmetic purposes. In 36 hours, the patient developed severe ARDS and respiratory support with V-V ECMO was initiated. The patient was successfully weaned from ECMO on day 11 and was discharged from hospital in full recovery.

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“…In contrast to intra-venous abuse of PPMT oil,[4] oral toxic dose of PPMT oil did not apparently cause lung injury. In the present case, mechanical ventilation was instituted for diminished respiratory drive, probably because of its central effect and not for acute lung injury.…”

Section: Discussionmentioning

confidence: 99%

“…[12] Side effects were described as minimally toxic,[4] whereas this case report shows that the side-effects could be dangerous and potentially fatal.…”

Section: Discussionmentioning

confidence: 99%

A near fatal case of high dose peppermint oil ingestion- Lessons learnt

2012

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Peppermint oil is easily available as a constituent of medicines. A near fatal case due to ingestion of toxic dose of oral peppermint oil is being reported. The patient came in a comatosed state and was in shock. She was managed with mechanical ventilation and ionotropes. Her vital parameters reached normal within 8 hours and became conscious by 24 hours. The side effects of peppermint oil are considered to be mild but this case report warns that ingestion of oral toxic doses of peppermint oil could be dangerous.

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Acute Lung Injury After Peppermint Oil Injection

Cited by 11 publications

References 7 publications

Menthol as an Ergogenic Aid for the Tokyo 2021 Olympic Games: An Expert-Led Consensus Statement Using the Modified Delphi Method

Menthol as an Ergogenic Aid for the Tokyo 2021 Olympic Games: An Expert-Led Consensus Statement Using the Modified Delphi Method

Extracorporeal membrane oxygenation after intravenous injection of paraffin oil

A near fatal case of high dose peppermint oil ingestion- Lessons learnt

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