Acute Lung Injury: A Clinical and Molecular Review

Butt, Yasmeen M.; Kurdowska, Anna; Allen, Timothy Craig

doi:10.5858/arpa.2015-0519-ra

Cited by 703 publications

(489 citation statements)

References 56 publications

Supporting

Mentioning

447

Contrasting

Order By: Relevance

“…4). However, IL-18 demonstrated a clear trend to increased levels after trauma, indicating at findings from others that have represented the importance of IL-18 as a promising biomarkers for predicting morbidity and mortality of ARDS [52]. Similar findings were reported by Dolinay et al (2012), showing that patients with trauma-or sepsis-induced ARDS had increased IL-18 levels, which correlated with increased in-hospital mortality [54].…”

Section: Discussionsupporting

confidence: 72%

“…This complex immune response to trauma is characterized by the release of several inflammatory mediators including IL-8, IL-1β, IL-10 and IL-18 but also neutrophil migration into the lung [13,[48][49][50][51][52][53]. Persistent accumulation of neutrophils in the lung has been linked to pulmonary damage and poor survival via an interstitial inflammation, increase of interstitial space and limitation of the oxygen transport [9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model

Störmann

Auner

Schimunek

et al. 2017

Prostaglandins, Leukotrienes and Essential Fatty Acids

View full text Add to dashboard Cite

A B S T R A C TBackground: Recognizing patients at risk for pulmonary complications (PC) is of high clinical relevance. Migration of polymorphonuclear leukocytes (PMN) to inflammatory sites plays an important role in PC, and is tightly regulated by specific chemokines including interleukin (IL)−8 and other mediators such as leukotriene (LT)B4. Previously, we have reported that LTB4 indicated early patients at risk for PC after trauma. Here, the relevance of LTB4 to indicating lung integrity in a newly established long-term porcine severe trauma model (polytrauma, PT) was explored. Methods: Twelve pigs (3 months old, 30 ± 5 kg) underwent PT including standardized femur fracture, lung contusion, liver laceration, hemorrhagic shock, subsequent resuscitation and surgical fracture fixation. Six animals served as controls (sham). After 72 h lung damage and inflammatory changes were assessed. LTB4 was determined in plasma before the experiment, immediately after trauma, and after 2, 4, 24 or 72 h. Bronchoalveolar lavage (BAL)-fluid was collected prior and after the experiment. Results: Lung injury, local gene expression of IL-8, IL-1β, IL-10, IL-18 and PMN-infiltration into lungs increased significantly in PT compared with sham. Systemic LTB4 increased markedly in both groups 4 h after trauma. Compared with declined plasma LTB4 levels in sham, LTB4 increased further in PT after 72 h. Similar increase was observed in BAL-fluid after PT. Conclusions: In a severe trauma model, sustained changes in terms of lung injury and inflammation are determined at day 3 post-trauma. Specifically, increased LTB4 in this porcine long-term model indicated a rapid inflammatory alteration both locally and systemically. The results support the concept of LTB4 as a biomarker for PC after severe trauma and lung contusion.

show abstract

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model

Störmann

Auner

Schimunek

et al. 2017

Prostaglandins, Leukotrienes and Essential Fatty Acids

View full text Add to dashboard Cite

show abstract

“…12 A recently published review of molecular studies found tumor necrosis factor a (TNFa), interleukin 1b (IL-1b), IL-8, and IL-18 as potential biomarkers of assessing morbidity and mortality, an area requiring further study. 15 The histologic findings in DAD vary depending on when the biopsy is taken during the progression of the disease course. Generally, the findings within a biopsy are diffuse and temporally uniform, unless sequelae of previous lung injury are also present.…”

Section: Diffuse Alveolar Damagementioning

confidence: 99%

Pulmonary Manifestations of Acute Lung Injury: More Than Just Diffuse Alveolar Damage

Hughes¹,

Beasley

2016

Archives of Pathology &Amp; Laboratory Medicine

132

View full text Add to dashboard Cite

Context.— Acute pulmonary injury may occur as a result of myriad direct or indirect pulmonary insults, often resulting in hypoxemic respiratory failure and clinical acute respiratory distress syndrome. Histologically, most patients will exhibit diffuse alveolar damage on biopsy, but other histologic patterns may be encountered, such as acute eosinophilic pneumonia, acute fibrinous and organizing pneumonia, and diffuse alveolar hemorrhage with capillaritis. Objective.— To review the diagnostic features of various histologic patterns associated with a clinical picture of acute lung injury, and to discuss key features in the differential diagnosis. Data Sources.— The review is drawn from pertinent peer-reviewed literature and the personal experience of the authors. Conclusions.— Acute pulmonary injury is a significant cause of morbidity and mortality. In addition to diffuse alveolar damage, pathologists should be aware of alternate histologic patterns of lung disease that may present with a similar clinical presentation because this may impact treatment decisions and disease outcome.

show abstract

“…Systemic inflammation leads to changes in structure and physiology of glycocalyx, inducing endothelial dysfunction. In an experimental model of sepsis, high levels of TNF-α were associated with shedding of the glycocalyx (26). Alleviate LPS-induced ARDS, which potentially contributed to the suppression of MAPK pathway activation and the degradation of endothelial glycocalyx (27).…”

Section: Eg and Inflammatory Cytokines And Oxidative Injurymentioning

confidence: 99%

The Endothelial Glycocalyx and One-Lung Ventilation Induced Lung Injury—New Focus

Yin¹,

Wang²,

Xia³

2016

J Anesth Perioper Med

View full text Add to dashboard Cite

Acute Lung Injury: A Clinical and Molecular Review

Cited by 703 publications

References 56 publications

Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model

Leukotriene B4 indicates lung injury and on-going inflammatory changes after severe trauma in a porcine long-term model

Pulmonary Manifestations of Acute Lung Injury: More Than Just Diffuse Alveolar Damage

The Endothelial Glycocalyx and One-Lung Ventilation Induced Lung Injury—New Focus

Contact Info

Product

Resources

About