Acute lower limb critical ischemia – a review article

Szíjártó, Attila; Turóczi, Zsolt; Arányi, Péter; Nagy, Zoltán Zsolt; Gyurkovics, Endre

doi:10.1556/oh.2010.28980

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…11 Although there was high serum myoglobin in our patient, there was no myogloninuria or significant sequelae of reperfusion syndrome. We performed prophylactic fasciotomy, which prevented compartmental syndrome from developing.…”

Section: Discussionmentioning

confidence: 47%

“…Revascularization of a severely ischemic limb causes reperfusion injury which causes more damage than ischemia alone locally and initiates a remote organ injury. 11 Although there was high serum myoglobin in our patient, there was no myogloninuria or significant sequelae of reperfusion syndrome. We performed prophylactic fasciotomy, which prevented compartmental syndrome from developing.…”

Section: Discussionmentioning

confidence: 47%

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Limb salvage in a child with severely injured mangled lower extremity and muscle rigor

Elsharawy¹,

Maher

Elsaid³

2012

Vascular

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Most surgeons make their decision to amputate or perform limb salvage of a mangled extremity based on scoring systems and grading of acute ischemic limb. We report on a child in whom limb salvage was achieved in spite of a clinical picture of irreversible ischemia with high mangled severity scores. Attempts to revascularize the mangled extremity of children are recommended, regardless of their severity scores and condition of the foot.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 47%

Limb salvage in a child with severely injured mangled lower extremity and muscle rigor

Elsharawy¹,

Maher

Elsaid³

2012

Vascular

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Alteration of sarcoplasmic reticulum Ca2+ ATPase expression in lower limb ischemia caused by atherosclerosis obliterans

et al. 2017

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Atherosclerosis is a disease caused by a build-up of fatty plaques and cholesterol in the arteries. The lumen of the vessels is obliterated resulting in restricted blood supply to tissues. In ischemic conditions, the cytosolic Ca level of skeletal muscle may increase, indicating the alteration of Ca removal mechanisms. Ca is transported from cytosol into the sarcoplasmic reticulum by Ca ATPase (SERCA), with its 1a isoform expressed in adult, while its 1b isoform in neonatal and regenerating fast-twitch skeletal muscle. To investigate the role of these isoforms in ischemic skeletal muscle, biopsies from musculus biceps femoris of patients who underwent amputation due to atherosclerosis were examined. Samples were removed from the visibly healthy and hypoxia-affected tissue. Significantly increased SERCA1a expression was detected under the ischemic conditions (246 ± 69%; p < 0.05) compared with the healthy tissue. Furthermore, the ratio of SERCA1a-positive fibers was slightly increased (46 ± 4% in healthy tissue and 60 ± 5% in ischemic tissue; p > 0.05), whereas SERCA2a did not change. In addition, in primary cultures derived from hypoxia-affected tissue, the diameter and fusion index of myotubes were significantly increased (30 ± 1.6 µm vs. 41 ± 2.4 µm and 31 ± 4% vs. 45 ± 3%; p < 0.05). We propose that the increased SERCA1a expression indicates the existence and location of compensating mechanisms in ischemic muscle.

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Resultados de un programa de oxígenoterapia hiperbárica para el tratamiento de Úlceras arteriales

2012

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ResumenLa Enfermedad Arterial Oclusiva Crónica (EAOC), es una entidad de sensibles impactos, dado que en sus mecanismos fisiopatológicos se genera una isquemia e hipoxia, que desvitalizan elementos tisulares dando paso a alteraciones integumentarias con aparición de úlceras de difícil manejo que se pueden sobreinfectar e incluso generar la amputación de extremidades. No siendo frecuente que en los tratamientos clínicos se dé la aplicación de oxígenoterapia hiperbárica, que podría reversar los mecanismos de alteraciones fisiopatológicas. Este trabajo corresponde a un estudio transversal desarrollado en la Unidad de Medicina Hiperbárica del Hospital Militar Central. Que contó con cuarenta y cinco pacientes intervenidos entre los años de 2004 a 2008.que presentaron úlceras arteriales arteriales. Los pacientes tenían una edad media de 68 años, habiendo recibido el 50% de ellos, un número de 20 sesiones, con una presión de 1.5 atmosferas en el 50% de los casos, lográndose una satisfactoria evolución de sus compromisos en el 77.7% de los casos (n=35, error estándar=0.03).Palabras Claves: Enfermedad arterial, úlceras arteriales, oxígenoterapia hiperbárica, oxígenoterapia hiperbárica en úlceras arteriales, tratamiento de úlceras arteriales. Results of a pRogRam of hypeRbaRic oxygen theRapy foR the tReatment of aRteRial ulceRs AbstractChronic Occlusive Arterial Disease (COAD) is an entity that has a significant impact since over its pathophysiological mechanisms ischemia and hypoxia are generated thus devitalizing tissue elements and giving rise to disturbances with the appearance of integumentary ulcers that can be unmanageable and even lead to superinfection and subsequent amputation of limbs. However, it is not common in clinical treatment to administer hyperbaric oxygen therapy even though it might reverse the mechanisms

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Acute lower limb critical ischemia – a review article

Cited by 3 publications

References 32 publications

Limb salvage in a child with severely injured mangled lower extremity and muscle rigor

Limb salvage in a child with severely injured mangled lower extremity and muscle rigor

Alteration of sarcoplasmic reticulum Ca2+ ATPase expression in lower limb ischemia caused by atherosclerosis obliterans

Resultados de un programa de oxígenoterapia hiperbárica para el tratamiento de Úlceras arteriales

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