Acute Lower Extremity Deep Venous Thrombosis: The Data, Where We Are, and How It Is Done

Ramaswamy, R.; Akinwande, Olaguoke; Giardina, Joseph D.; Kavali, P.; Marks, Christina

doi:10.1053/j.tvir.2018.03.006

Cited by 8 publications

(12 citation statements)

References 39 publications

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“…Venous thromboembolism, which includes DVT and PE, is a significant source of morbidity and mortality. Recurrent DVT, post-pulmonary embolism syndrome, chronic thromboembolic pulmonary hypertension, and post-thrombotic syndrome are longterm complications of venous thromboembolism [12]. Proximal DVT of the lower extremities, symptomatic calf vein (distal) DVT, and PE require immediate treatment with anticoagulant agents unless anticoagulation is contraindicated because of high bleeding risk [13].…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes in lower extremity deep vein thrombosis treated with a direct oral anticoagulant: A retrospective cohort study

Atabey¹,

Akçalı²

2021

Journal of Surgery and Medicine

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Section: Discussionmentioning

confidence: 99%

Clinical outcomes in lower extremity deep vein thrombosis treated with a direct oral anticoagulant: A retrospective cohort study

Atabey¹,

Akçalı²

2021

Journal of Surgery and Medicine

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“…El cuadro clínico de esta entidad es variado, el 50% de los pacientes cursan asintomáticos y el resto de los casos presentan un espectro amplio de signos y síntomas por lo que es imprescindible un diagnóstico oportuno (2). Los pacientes con trombosis venosa en miembros inferiores, se caracterizan por presentar edema, dolor localizado e inflamación en una o ambas extremidades , con cambios en la percepción del dolor y del color (10).…”

Section: Clínicaunclassified

“…e360 Revista Médica Sinergia Vol. 5 (2), Febrero 2020 -ISSN:2215-4523 / e-ISSN: http://revistamedicasinergia.com…”

Section: Introductionunclassified

“…En la revisión realizada por Marcelo Di Nicio et all refiere que la carga económica anual por trombo embolismo venoso en los Estados Unidos ronda de los 7 a 10 billones de dólares (1,9). En resumen, esta patología tiene un gran impacto a nivel social, económico y epidemiológico por lo que es de vital importancia un diagnóstico rápido y correcto para disminuir la tasa de reincidencias y de complicaciones mortales (2). El objetivo de este artículo es realizar una revisión bibliográfica sobre el abordaje de la trombosis venosa profunda de miembros inferiores en los servicios de salud con el fin de identificar a los pacientes con clínica sospechosa de trombosis venosa profunda para un e360 Revista Médica Sinergia Vol.…”

Section: Introductionunclassified

“…El objetivo de este artículo es realizar una revisión bibliográfica sobre el abordaje de la trombosis venosa profunda de miembros inferiores en los servicios de salud con el fin de identificar a los pacientes con clínica sospechosa de trombosis venosa profunda para un e360 Revista Médica Sinergia Vol. 5 (2)…”

Section: Introductionunclassified

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Abordaje de trombosis venosa profunda en miembros inferiores

Sandino

Vega

2020

Rev.méd.sinerg.

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La trombosis venosa profunda en miembros inferiores, es una enfermedad frecuente dentro de los servicios de emergencias, por lo que es de suma importantancia su correcto diagnóstico y tratamiento. La edad, la inmovilización y la cirugía ortopédica han sido desencadenantes claves para el inicio de la obstrucción del vaso sanguíneo y su migración. El uso de la Escala de Wells es una herramienta clave para categorizar y realizar un manejo apropiado, sin caer en el uso de exámenes no necesarios ni costosos, el uso eficaz de los anticoagulantes parenterales y la warfarina han permitido una disminución de la incidencia de complicaciones graves en estos pacientes.

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Numerical simulation and experimental validation of thrombolytic therapy for patients with venous isomer and normal venous valves

Lin

Zhang

et al. 2023

Numer Methods Biomed Eng

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Thrombus is an extremely dangerous factor in the human body that can block the blood vessel. Once thrombosis happens in venous of lower limbs, local blood flow is impeded. This leads to venous thromboembolism (VTE) and even pulmonary embolism. In recent years, venous thromboembolism has frequently occurred in a variety of people, and there is no effective treatment for patients with different venous structures. For the patients with venous isomer with single valve structure, we establish a coupled computational model to simulate the process of thrombolysis with multi‐dose treatment schemes by considering the blood as non‐Newtonian fluid. Then, the corresponding in vitro experimental platform is built to verify the performance of the developed mathematical model. At last, the effects of different fluid models, valve structures and drug doses on thrombolysis are comprehensively studied through numerical and experimental observations. Comparing with the experimental results, the relative error of blood boosting index (BBI) obtained from non‐Newtonian fluid model is 11% smaller than Newtonian fluid. In addition, the BBI from venous isomer is 1300% times stronger than patient with normal venous valve while the valve displacement is 500% times smaller. As consequence, low eddy current and strong molecular diffusion near the thrombus in case of isomer promote thrombolysis rate up to 18%. Furthermore, the 80 μM dosage of thrombolytic drugs gets the maximum thrombus dissolution rate 18% while the scheme of 50 μM doses obtains a thrombolysis rate of 14% in case of venous isomer. Under the two administration schemes for isomer patients, the rates from experiments are around 19.1% and 14.9%, respectively. It suggests that the proposed computational model and the designed experiment platform can potentially help different patients with venous thromboembolism to carry out clinical medication prediction.

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Acute Lower Extremity Deep Venous Thrombosis: The Data, Where We Are, and How It Is Done

Cited by 8 publications

References 39 publications

Clinical outcomes in lower extremity deep vein thrombosis treated with a direct oral anticoagulant: A retrospective cohort study

Clinical outcomes in lower extremity deep vein thrombosis treated with a direct oral anticoagulant: A retrospective cohort study

Abordaje de trombosis venosa profunda en miembros inferiores

Numerical simulation and experimental validation of thrombolytic therapy for patients with venous isomer and normal venous valves

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