Acute loss of spatial navigational skills in a case of a right posterior hippocampus stroke

Aradillas, Enrique; Libon, David J.; Schwartzman, Robert J.

doi:10.1016/j.jns.2011.06.026

Cited by 15 publications

(8 citation statements)

References 29 publications

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“…Visual and behavioural tests consisting of complex figures and designs were mostly impaired in those with lesions involving especially the right anterior nuclei, body and subiculum. Our data support previous studies suggesting that the right hippocampus seems to be strongly involved in spatial memory and navigational processing [26][27][28]. The clinical picture characterized by severe immediate, delayed verbal and visual memory deficits, dysexecutive syndrome, constant need for drive himself, deficits in responding to feedback and error correction with dull and aimless appearance lasting several months in one patient with unilateral complete lesions and in two with bilateral hippocampal lesions has been considered as hippocampal dementia.…”

Section: Discussionsupporting

confidence: 90%

Isolated hippocampal infarcts: Vascular and neuropsychological findings

Kumral

Deveci

Erdoğan

et al. 2015

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 90%

Isolated hippocampal infarcts: Vascular and neuropsychological findings

Kumral

Deveci

Erdoğan

et al. 2015

Journal of the Neurological Sciences

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“…This complexity is further enhanced by the topographical distribution, as well as the ventral/dorsal localization, of these peptides and their receptors in the different subfields of the hippocampus. Each zone may be a site for the precise regulation of different memories …”

Section: Resultsmentioning

confidence: 99%

“…Each zone may be a site for the precise regulation of different memories. 406 It should also be noted that memory installation is not systematically linked to the actions of various peptides on neurogenesis ( Table 2). When neurogenesis and memory are associated, they sustain themselves in a reciprocal manner, with learning increasing neuron survival and integration into hippocampal networks, and longer-living neurons facilitating learning.…”

Section: Resultsmentioning

confidence: 99%

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck

Pourié

2013

Nutr Rev

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The hippocampus is a brain region of primary importance for neurogenesis, which occurs during early developmental states as well as during adulthood. Increases in neuronal proliferation and in neuronal death with age have been associated with drastic changes in memory and learning. Numerous neurotransmitters are involved in these processes, and some neuropeptides that mediate neurogenesis also modulate feeding behavior. Concomitantly, feeding peptides, which act primarily in the hypothalamus, are also present in the hippocampus. This review aims to ascertain the role of several important feeding peptides in cognitive functions, either through their local synthesis in the hippocampus or through their actions via specific receptors in the hippocampus. A link between neurogenesis and the orexigenic or anorexigenic properties of feeding peptides is discussed.

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“…Furthermore, the posterior hippocampus plays a significant role in both the encoding and retrieval of spatial memory, orientation, and navigation [ 22 ]. It has different functions than the anterior hippocampus; whereas the posterior hippocampus is mainly involved in cognitive functions, the anterior is more involved in emotional processes [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“Taller and Shorter”: Human 3-D Spatial Memory Distorts Familiar Multilevel Buildings

et al. 2015

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Animal experiments report contradictory findings on the presence of a behavioural and neuronal anisotropy exhibited in vertical and horizontal capabilities of spatial orientation and navigation. We performed a pointing experiment in humans on the imagined 3-D direction of the location of various invisible goals that were distributed horizontally and vertically in a familiar multilevel hospital building. The 21 participants were employees who had worked for years in this building. The hypothesis was that comparison of the experimentally determined directions and the true directions would reveal systematic inaccuracy or dimensional anisotropy of the localizations. The study provides first evidence that the internal representation of a familiar multilevel building was distorted compared to the dimensions of the true building: vertically 215% taller and horizontally 51% shorter. This was not only demonstrated in the mathematical reconstruction of the mental model based on the analysis of the pointing experiments but also by the participants’ drawings of the front view and the ground plan of the building. Thus, in the mental model both planes were altered in different directions: compressed for the horizontal floor plane and stretched for the vertical column plane. This could be related to human anisotropic behavioural performance of horizontal and vertical navigation in such buildings.

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Acute loss of spatial navigational skills in a case of a right posterior hippocampus stroke

Cited by 15 publications

References 29 publications

Isolated hippocampal infarcts: Vascular and neuropsychological findings

Isolated hippocampal infarcts: Vascular and neuropsychological findings

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

“Taller and Shorter”: Human 3-D Spatial Memory Distorts Familiar Multilevel Buildings

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