Acute localized exanthematous pustulosis (<scp>ALEP</scp>) induced by iomeprol (Iomeron 350): A diagnostic challenge

Navarro‐Triviño, Francisco José; Linares‐González, Laura; Ródenas‐Herranz, Teresa; Llamas‐Molina, José María; Ruiz‐Villaverde, Ricardo

doi:10.1111/cod.13790

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…6 There is only one published case of ALEP to iodinated contrast agents, which was caused by iomeprol (Iomeron 350) and confined to the neck and chest. 7 In conclusion, our case shows that ioversol may be a causative agent of ALEP, expanding the range of cutaneous side effects in the use of cerebral angiography for examination and treatment.…”

Section: Discussionmentioning

confidence: 69%

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Acute localised exanthematous pustulosis (ALEP)‐induced by ioversol

Xie,

Rong,

Cai

et al. 2023

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Section: Discussionmentioning

confidence: 69%

“…Cross‐reactivity between different types of iodinated contrast agents had been demonstrated 6 . There is only one published case of ALEP to iodinated contrast agents, which was caused by iomeprol (Iomeron 350) and confined to the neck and chest 7 …”

Section: Discussionmentioning

confidence: 99%

Acute localised exanthematous pustulosis (ALEP)‐induced by ioversol

Xie,

Rong,

Cai

et al. 2023

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“…Patch tests have infrequently been performed in ALEP; positive reactions have been observed only to amoxicillin-clavulanic acid, 40 bemiparin, 46 iomeprol, 36,47 metronidazole, 48 and nimesulide. 5…”

Section: Prognosismentioning

confidence: 99%

“…Analogous to AGEP, ALEP is thought to be due to drug‐specific T cell–mediated immune processes, as shown by positive patch tests and lymphocyte transformation tests 45 in response to culprit drugs. Patch tests have infrequently been performed in ALEP; positive reactions have been observed only to amoxicillin‐clavulanic acid, 40 bemiparin, 46 iomeprol, 36,47 metronidazole, 48 and nimesulide 5…”

Section: Acute Localized Exanthematous Pustulosis (Alep)mentioning

confidence: 99%

Results of patch testing in acute generalized exanthematous pustulosis (AGEP): A literature review

Groot¹

2022

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The literature on positive patch‐test results in acute generalized exanthematous pustulosis (AGEP) is reviewed. Ninety‐three drugs were identified that have together caused 259 positive patch tests in 248 patients with AGEP. The drug classes causing the highest number of reactions are beta‐lactam antibiotics (25.9%), other antibiotics (20.8%), iodinated contrast media (7.3%), and corticosteroids (5.4%), together accounting for nearly 60% of all reactions. The highest number of reactions to individual drugs was to amoxicillin (n = 36), followed by pristinamycin (n = 25), diltiazem (n = 14), amoxicillin‐clavulanic acid (n = 13), clindamycin (n = 11), and iomeprol (n = 8); 59 of the 93 drugs each caused a single case only. The “Top‐10” drugs together caused over 50% of all reactions. The sensitivity of patch testing (percentage of positive reactions) in patients with AGEP is largely unknown, but may generally be ~50%, which also applies to pristinamycin. Patch testing in AGEP appears to be safe, although mild recurrence of AGEP skin symptoms or other rashes may occur occasionally. Clinical aspects of AGEP, including epidemiology, etiology and pathophysiology, clinical features, histology, treatment, and prognosis are briefly presented, as are diagnosing the disease and identifying the culprit drugs with patch tests, intradermal tests, in vitro tests, and challenge tests.

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Iomeprol

2021

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Acute localized exanthematous pustulosis (ALEP) induced by iomeprol (Iomeron 350): A diagnostic challenge

Cited by 3 publications

References 13 publications

Acute localised exanthematous pustulosis (ALEP)‐induced by ioversol

Acute localised exanthematous pustulosis (ALEP)‐induced by ioversol

Results of patch testing in acute generalized exanthematous pustulosis (AGEP): A literature review

Iomeprol

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