Acute Localized Exanthematous Pustulosis on Inguinal Area Secondary to Piperacillin/tazobactam

Huilaja, Laura; Kallioinen, Matti; Soronen, Minna; Riekki, Riitta; Tasanen, Kaisa

doi:10.2340/00015555-1629

Cited by 12 publications

(15 citation statements)

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“…To date, only about 25 cases have been reported. Sterile pustular eruptions that spare mucosal surfaces, do not generalize, and manifest only occasionally with systemic symptoms of fever and leucocytosis typify ALEP . Lesions commonly develop on the face, but involvement of the neck, trunk and inguinal areas has also been reported .…”

Section: Discussionmentioning

confidence: 99%

Localized, ovoid urticarial plaques with fine, nonfollicular pustules

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Localized, ovoid urticarial plaques with fine, nonfollicular pustules

et al. 2017

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“…7,8,10 IL-8 is likely responsible for recruiting neutrophils in the intraepithelial pustules. Recently, a relative increase in TH17 cell numbers and elevated levels of cytokine IL-22 in the peripheral blood of patients with AGEP was shown.…”

Section: Discussionmentioning

confidence: 99%

“…The definition of ALEP was introduced by Prange et al 2 Over 15 ALEP cases have subsequently been reported. 2-8 …”

Section: Discussionmentioning

confidence: 99%

“…Recently, a similar case with lesion onn the upper thigh was reported following piperacillin/tazobactam use. 8 …”

Section: Discussionmentioning

confidence: 99%

“…2 Previous studies have found that drugs like amoxicillin, levofloxacin, paracetamol, ibuprofen, finasteride and piperacillin/tazobactam may induce ALEP attacks. 3-8 Herein, the authors describe a case of ALEP associated with cefoperazone and sodium sulbactam.…”

Section: Introductionmentioning

confidence: 99%

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Acute localized exanthematous pustulosis caused by cefoperazone and sodium sulbactam

Qu¹,

Jin²,

Han³

et al. 2016

An. Bras. Dermatol.

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Acute localized exanthematous pustulosis is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 72-year-old woman presented with multiple erythematous pustules on her face, which had appeared two days after using cefoperazone and sodium sulbactam. Histopathological findings showed subcorneal pustules and mixed inflammatory cell infiltration in the dermis. The pustules resolved within about two weeks after the patient discontinued the antibiotics. This report discusses the case of a woman with a cutaneous drug reaction consistent with acute localized exanthematous pustulosis that occurred after cefoperazone and sodium sulbactam were administered.

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