Acute liver failure secondary to Langerhans cell histiocytosis

Liver Langerhans cell histiocytosis in a pediatric patient: a case description and literature analysis

“…Liver involvement in disseminated LCH indicates the late phase of LCH ( 11 , 12 ) and is likely to be found in the gastrointestinal tract of most affected children, traveling through the portal vein to the blood stream and ultimately into the liver and causing infection of the biliary tract or liver parenchyma ( 13 ). In one case report, the patient had acute liver failure with cutaneous, renal, pituitary, and hematologic manifestations of secondary LCH ( 14 ). The liver transplant was the only solution for a cure.…”