Acute liver failure in adults

Лукашик, С. П.; Karpov, Igor

doi:10.36488/cmac.2019.1.46-55

Cited by 3 publications

(2 citation statements)

References 89 publications

(129 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Сосудистые реакции и нарушение проницаемости сосудистой стенки являются одним из звеньев патогенеза развития пострезекционной печеночной недостаточности. Таким образом, возможно неблагоприятное воздействие гипергомоцистеинемии на функцию и восстановления паренхимы печени у больных с острой печеночной недостаточностью после резекции печени [2,7,9].…”

Section: Discussionunclassified

“…Она характеризуется острым, быстро развивающим поражением печени с высокой долей летальных исходов. Прогноз и развитие заболевания зависит от различных факторов, но в первую очередь от ранней и своевременной диагностики, и правильной этиотропной и патогенетической терапии [1,2].…”

Section: Introductionunclassified

See 1 more Smart Citation

Levels of plasma homocysteine dynamics speciality in the development of acute postresection hepatic failure

Дунаевская

Kosik

Наркевич

2021

jour

View full text Add to dashboard Cite

This study aims to evaluate the level of plasma homocysteine in patients with acute post-resection hepatic failure, depending on the degree of the disease. Materials and Methods. The article presents the results of a study of plasma homocysteine levels in 40 patients with c different classes of acute post-resection liver failure. Indications for liver resection were: primary liver cancer 11 (27%), metastatic liver lesions 21 (53%), parasitic liver diseases 3 (7%), benign liver formations 5 (13%). Patients were divided into 3 groups - Patients with Post hepatectomy liver failure (PHLF) class developed in the postoperative period A, B and C. Results. Analysis of the data showed that the initially normal level of plasma homocysteine before liver resection (surgical treatment) and after has different developmental options. Depending on the class of post-resection hepatic failure, the level of plasma homocysteine changes and has deviations from the reference values. In a comparative analysis of the average homocysteine values in the group of patients with post-resection hepatic insufficiency of class A, after surgical treatment, they were significantly lower than in patients with PHLF B and C. In particular, in patients with class B and C PNF, there is a significant trend towards an increase in homocysteine levels after surgery. Hyperhomocysteinemia may be a risk factor for the development of acute liver failure after surgical treatment for focal liver disease. Possibly, its adverse effect on the function and restoration of the liver parenchyma, which requires further targeted study.

show abstract

Section: Discussionunclassified

Section: Introductionunclassified

Levels of plasma homocysteine dynamics speciality in the development of acute postresection hepatic failure

Дунаевская

Kosik

Наркевич

2021

jour

View full text Add to dashboard Cite

show abstract

Extracorporeal Blood Purification in Intensive Therapy of Acute Liver Failure

Yakubtsevich¹

2020

Hepatol Gastroenterol

View full text Add to dashboard Cite

Гродненский государственный медицинский университет, Гродно, БеларусьИнтенсивная терапия острой печеночной недостаточности включает применение гепатопротекторов, интракорпоральной детоксикации, коррекции коагулопатии и энцефалопатии, а в случае фульминантной формы -трансплантации печени. Использование методов экстракорпорального очищения крови имеет место в большинстве случаев лечения данной патологии. Однако выбор того или иного метода, а также сроки их применения остаются предметом дискуссий.В обзоре литературы представлен анализ 46 литературных источников с целью изучения современных подходов к применению методов экстракорпорального очищения крови при острой печеночной недостаточности.Ключевые слова: острая печеночная недостаточность, гемокарбоперфузия, плазмаферез, экстракорпоральная поддержка печени, живые культуры гепатоцитов.

show abstract

Use of mesenchymal stem cells to accelerate regeneration processes in acute toxic liver injury in an experiment

Trapeznikova

Шилов

2022

Med. tr. prom. èkol.

View full text Add to dashboard Cite

Introduction. The impact of a complex chemical load on the population of the whole world, the use of pharmacological preparations, alcohol-containing products are the main factors that determine the high frequency and prevalence of toxic hepatitis. The search for new approaches for the treatment of toxic liver damage in order to restore structural and functional disorders is one of the urgent tasks of medicine. Of particular interest are the methods of regenerative medicine based on the use of various types of stem cells. Purpose of the study - study of the effect of transplantation of multipotent mesenchymal stem cells on the processes of regeneration in the liver of rats with induced acute toxic hepatitis. Materials and methods. An experimental study was conducted on 114 outbred male rats (3-5 months old) weighing 250-390 g. The animals were divided into 3 main groups. Group 1 - control animals (n=15). Group 2 (positive control) single intragastric injection of an oil solution of carbon tetrachloride (CCl4) at a dose of 1500 mg/kg (n=41); Group 3 (n=58) intragastrically injected with CCl4 at a dose of 1500 mg/kg, and intravenous transplantation of MMSC of 2×106, was carried out. On the 1st, 3rd, 5th, 7th day of the experiment as well as the collection of organs and tissues for histological and morphometric studies was made. Results. According to immunofluorescent analysis, intravenously transplanted MMSCs were found in the liver of rats at the 3rd and all subsequent periods of observation. In the present study, MMSC transplantation led to a statistically significant decrease in infiltrative processes in the liver tissue on the 3rd and 5th days of the study by 28.3% (p<0.0001) and 18.75% (p=0.0074) according to compared with the positive control group. On day 7, MMSC transplantation reduced the degree of fatty degeneration of the organ. The decrease in pathological manifestations of toxic hepatitis in rats is associated with an earlier activation of the mechanisms of reparative regeneration. Implementation of liver regeneration against the background of MMSC transplantation was carried out by enhancing protein-synthetic processes in liver cells, as well as increasing the mitotic activity of hepatocytes. Conclusions. The conducted experimental study showed that MMSC transplantation is an effective method of stimulating regenerative processes in the liver after its acute toxic damage. Limitations. In this experiment, lipid peroxidation processes in rat liver cells were not assessed, these criteria were not included in the study, and may be the subject of further study. Ethics. Work with laboratory animals was carried out with the approval of the bioethical committee of the North-Western State Medical University. I.I. Mechnikov dated November 11, 2020, as well as in accordance with the international GLP rules adopted in the Russian Federation (Rules for Good Laboratory Practice), Order No. 267 of the Ministry of Health of the Russian Federation dated June 19, 2003.

show abstract

Acute liver failure in adults

Cited by 3 publications

References 89 publications

Levels of plasma homocysteine dynamics speciality in the development of acute postresection hepatic failure

Levels of plasma homocysteine dynamics speciality in the development of acute postresection hepatic failure

Extracorporeal Blood Purification in Intensive Therapy of Acute Liver Failure

Use of mesenchymal stem cells to accelerate regeneration processes in acute toxic liver injury in an experiment

Contact Info

Product

Resources

About