Acute liver failure due to natural killer-like T-cell leukemia/lymphoma: A case report and review of the Literature

Dellon, Evan S.; Morris, Shannon R.; Tang, Wozhan; Dunphy, Cherie H.; Russo, Mark W.

doi:10.3748/wjg.v12.i25.4089

Cited by 22 publications

(9 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Acute liver failure is a rare medical emergency requiring immediate actions, both in the diagnostic and therapeutic fields; setting proper diagnosis decides on further treatment, predetermining transplantation procedure or converselyrejecting it as a therapeutic option [1,2,5,9]. The number of symptoms presented by a patient blurs the image of ALF, misleading the diagnostician.…”

Section: Discussionmentioning

confidence: 99%

“…Although ALF is characterized by a high mortality rate, the outcomes have improved due to liver transplantation procedures (the survival rate formerly stated as 15%, nowadays exceeds 65%) [1,2,5,8]. Qualification to this procedure requires prior screening for all the possible contraindications and stating accurate diagnosis, together with the primary cause, is essential in this situation [9]. However, the symptoms of ALF are non-specific, as presented by a number of dysfunctional systems, significantly hampering the diagnostic process.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state – Case report

Kuczyńska¹,

Dziaduch²,

Grzywa-Celińska³

et al. 2014

J Pre Clin Clin Res.

View full text Add to dashboard Cite

Kuczyńska M, Dziaduch E, Grzywa-Celińska A, Lachowska-Kotowska P, Mosiewicz J. Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state -Case report. J Pre-Clin Clin Res. 2014; 8(1): 41-43. AbstractAcute liver failure (ALF) is a rare condition in which liver function deteriorates suddenly, leading to encelopathy and coagulopathy in patients previously unaffected with hepatic cirrhosis. The case is presented of a 60-year-old woman admitted to our Department with complaints of general malaise, excessive sweating and body temperature elevation. Her history was relevant in terms of T-cell lymphoma in remission, hypertension and paroxysmal atrial fibrillation. The patient only reported using methylprednisolone in 4-8 mg daily dosage. Liver function tests were abnormal, with considerably elevated ALT, AST and GGTP concentrations. Diagnostic imaging revealed non-dilated biliary ducts, hepatomegaly and a single enlarged lymph node between the inferior vena cava and hepatic portal vein. A needle biopsy of the liver was nondiagnostic due to protein masses blurring the specimen. Autoimmune markers and investigation for Wilson's disease both presented no alterations. The patient presented hyperthyroidism with no signs of thyrotoxicosis, significant leukocytosis with granulocytosis and thrombocytopenia. Her state deteriorated rapidly despite aggressive pharmacological treatment. The patient died before a needle core biopsy could be performed; no post-mortem examination was carried out at the request of the family. ALF should be suspected in every patient who exhibits highly elevated hepatic enzymes and whose condition is deteriorating rapidly. In our investigation, we should primarily focus on histopathological examination and qualifying the patient for the liver transplantation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state – Case report

Kuczyńska¹,

Dziaduch²,

Grzywa-Celińska³

et al. 2014

J Pre Clin Clin Res.

View full text Add to dashboard Cite

show abstract

“…Hodgkin and non-Hodgkin lymphomas, acute leukemias, and transformation of chronic leukemias to acute stages have all been associated with sporadic cases of acute liver failure [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] . The important step in the diagnosis of such pathologies is a liver biopsy once other obstructive, toxic, and infective causes of liver failure have been ruled out by laboratory tests and imaging studies.…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Failure Because of Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2011

View full text Add to dashboard Cite

Infiltration of the liver by hematologic malignancies is an uncommon cause of liver failure. B-Cell chronic lymphocytic leukemia (CLL) is a usually indolent disease that may infiltrate the liver, but based on a review of the literature, has never been reported to induce acute liver failure. Here, we describe the case of a 78-year-old woman with acute liver failure secondary to infiltration with CLL being unresponsive to chemotherapy and causing death. This case is notable because of its atypical presentation and ultimate poor prognosis.

show abstract

“…Multifocal to diffuse liver involvement is often associated with hepatocyte dysfunction and jaundice, the latter being a risk factor for early death (Zhang et al 2013). In massive liver infiltration, acute liver failure due to hepatocyte loss can develop (Dellon et al 2006). Apart from the effects of tissue infiltration, liver dysfunction in patients with ANKL is also supposed to be caused by interaction between Fas and Fas ligand (Makishima et al 2007).…”

Section: Liver Involvementmentioning

confidence: 99%

T-Cell Non-Hodgkin’s Lymphomas

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

View full text Add to dashboard Cite

Several types of T-cell non-Hodgkin's lymphomas are characterized by liver involvement, usually in the context of generalized lymphoma disease. The aggressive neoplasm, T-cell prolymphocytic leukemia, showing a proliferation of small-to medium-sized T cells, results in massive bone marrow infiltration and marrow failure but also infiltrates the lymph nodes, liver, and spleen. Hepatic infiltrates mostly involve portal tracts, causing hepatomegaly. Hepatic involvement is a common feature of T-cell large granular lymphocytic leukemia. Liver infiltration is also known for aggressive NK cell leukemia, a systemic proliferation of NK cells almost always associated with EBV infection. The liver may be densely infiltrated by large granular lymphocytes with azurophilic granules. The generalized neoplastic T-lymphocyte process, adult T-cell leukemia/lymphoma, is frequently complicated by focal t diffuse parenchymal or portal tract infiltration of the liver. Other T-cell neoplasms variably involving the liver comprise nasal-type extranodal NK/T-cell lymphoma, hepatosplenic T-cell lymphoma, mycosis fungoides, Sézary syndrome, and peripheral T-cell lymphomas. T-Cell Prolymphocytic Leukemia ICD-O Code 9834/3 T-Cell Large Granular Lymphocytic Leukemia ICD-O Code 9831/3 T-cell receptor genes are in germline configuration and, therefore cannot be employed for clonality assessment. A part of the cases reveal clonal del (6)(q21q25) and 11q deletion.

show abstract

Acute liver failure due to natural killer-like T-cell leukemia/lymphoma: A case report and review of the Literature

Cited by 22 publications

References 44 publications

Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state – Case report

Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state – Case report

Acute Liver Failure Because of Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

T-Cell Non-Hodgkin’s Lymphomas

Contact Info

Product

Resources

About