Acute liver failure associated with Coxsackie virus B2 infection in a neonate

Wallot, M.; Metzger-Boddien, Christoph; Auth, Marcus K.H.; Kehle, Johannes; Enders, Gisela; Dirsch, Olaf; Fiedler, Melanie; Voït, Thomas

doi:10.1007/s00431-003-1377-6

Cited by 8 publications

(7 citation statements)

References 4 publications

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“…Coxsackie B virus has been described as an uncommon source of hepatitis. It has been described in the literature infrequently in individual case reports from 1962-2001 [11][12][13][14][15][16] .A case report in 2006 detailed a patient who was diagnosed with hepatitis and had a concurrent rise in Coxsackie antibody titers in the serum [15] . More recently, a report from 2009 describes a patient with hepatitis and Coxsackie A9 positivity with peak AST and ALT levels 6 days after development of symptoms [13] .…”

Section: Discussionmentioning

confidence: 99%

A case of coxsackie B virus infection leading to multi-organ inflammation: Myopericarditis and acute liver failure

Zaheeruddin

Bade

Jani

et al. 2014

CRIM

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Myopericarditis refers to the development of acute pericarditis with myocardial involvement. Viral infections, including Coxsackie B virus, are amongst the most common causes of myopericarditis. The Coxsackie B viruses are known to have a role in the development of a number of clinical diseases including but not limited to cardiac disease, central nervous system infections, ocular infections, pleurodynia, gastrointestinal disease, and viral exanthems. In individual cases, Coxsackie B virus may also be associated with acute hepatitis. We describe a rare case of a 41 year-old female with multi-organ inflammation caused by Coxsackie B virus leading to myopericarditis, pleuritis, and acute liver failure. Laboratory and imaging data helped to make diagnosis of myopericarditis and appropriate management was initiated. Shortly after the patient developed acute liver failure with an INR greater than 13 and AST and ALT of 7946 u/L and 5684 u/L, respectively. Viral serology revealed Coxsackie B 1, 2, and 6 serum antibody positivity (> 1:32 titer) indicating acute or recent infection. A complete workup for other liver failure etiologies was negative. The case shows the significance of awareness and recognition of the possible complications of Coxsackie B virus infection including liver failure.

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Section: Discussionmentioning

confidence: 99%

A case of coxsackie B virus infection leading to multi-organ inflammation: Myopericarditis and acute liver failure

Zaheeruddin

Bade

Jani

et al. 2014

CRIM

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“…La infección por virus Coxsackie B también se ha asociado a pancreatitis (17), nefritis (18), pleurodinia, hepatitis (8,19), meningoencefalitis (20) y artritis (7,19). La miositis puede incrementar algo las concentraciones séricas de transaminasas.…”

Section: Evolución De Los Parámetros De Laboratoriounclassified

“…Existen pocas referencias en la literatura sobre la asocia-ción entre infección por virus Coxsackie B y el desarrollo de miositis (6), poliartritis (7) o hepatitis (8). Por estos motivos, consideramos de interés describir el caso de una niña de seis años que presentó fiebre, herpangina y exantema maculopapular no pruriginoso, al que se sumaron polimiositis y poliartritis simétrica.…”

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Miositis y poliartritis asociada a infección por virus Coxsackie B

Rodríguez

Ruán

Rodríguez

2008

An. Med. Interna (Madrid)

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A wide spectrum of muscle disorders caused by Coxsackie B virus, ranging from acute nonspecific myalgia to rhabdomyolisis have been described. Arthritis in not widely recognised as an either manifestation of Coxsackie virus infection, and only ten patients has been reported previously. A case of polymyositis and polyarthritis associated with primary Coxsackie B infection in a 6-year-old girl is reported. Seroconversion of IgM and IgG antibodies for Coxsackie virus B was observed coinciding with the clinical features: fever, herpangine, polyarthritis, erythematous macular rash, myalgia and muscle weakness with high levels of aldolase and creatine kinase. Electromyographic changes of myositis were found. However, histopathologically biopsied muscle demonstrated a slight inflammatory mononuclear cell infiltrate without necrosis or regeneration of muscle fibres. Polyarthritis and full muscle strength was recovered 8 and 32 weeks after the onset, respectively.

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“…Destacam-se seis sorotipos do vírus Coxsackie B que se manifestam com febre, exantema, vesículas e lesões ulceradas orais, doença mão-pé-boca, pleurodinia epidêmica (doença aguda caracterizada por febre e espasmos paroxísticos dos músculos torácicos e abdominais, mais frequente em adolescentes e adultos), pancreatite, miosite e cardiomiopatia dilatada (4) . Embora a maioria das infecções pelo vírus Coxsackie seja assintomática, podem ser graves, especialmente em neonatos e crianças pequenas, com acometimento do sistema nervoso central e dos músculos, causando complicações como meningite asséptica, encefalite, miosite e miocardite (5) . Na literatura têm sido descritos casos de rabdomiólise desencadeada pelo vírus Coxsackie, com aumento importante de enzimas musculares, insuficiência renal aguda não-oligúrica e, muitas vezes, com necessidade de diálise.…”

Section: Introductionunclassified

“…Nosso objetivo é relatar um caso de doença mão-pé-boca, com acometimento muscular importante, rabdomiólise e hepatite, enfatizando os critérios clínicos laboratoriais relevantes para o diagnóstico e a importância da monitorização das complicações da doença, lembrando que tal virose representa causa frequente de doença exantemática na infância e que essas complicações são raramente descritas na literatura (5,6) .…”

Section: Introductionunclassified

Miosite e rabdomiólise na doença mão-pé-boca na infância

Vaisbich

Tozze

Baldacci

2010

Rev. paul. pediatr.

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OBJETIVO: Relatar um caso de doença mão-pé-boca complicada por miosite, rabdomiólise e hepatite, interessante por ser a doença frequente em crianças e poder apresentar complicações graves, apesar de raras. DESCRIÇÃO DO CASO: Paciente de três anos de idade, sexo feminino, com história de febre por três dias, seguida pelo aparecimento de lesões ulceradas em mucosa oral e mialgia intensa. Após três dias, voltou a apresentar febre por mais dois dias (febre bifásica). Nesses dois dias, apresentou lesões eritematosas pelo corpo, principalmente nos pés, mãos e face, e procurou atendimento médico. Evoluiu com aumento de enzimas musculares e hepáticas (CPK com valor máximo de 345.007U/L, TGO 2041U/L, TGP 1589U/L, gama-GT 94U/L) e aumento transitório da creatinina sérica, com clearance de creatinina estimado pela estatura de 73mL/minuto/1,73m2 de superfície corporal. Houve melhora progressiva, com hidratação vigorosa e alcalinização da urina, sem necessidade de diálise. COMENTÁRIOS: Trata-se de uma criança com doença mão-pé-boca, com miosite, rabdomiólise e hepatite. São enfatizados os critérios clínicos laboratoriais para o diagnóstico e a importância da monitorização das complicações da doença

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Acute liver failure associated with Coxsackie virus B2 infection in a neonate

Cited by 8 publications

References 4 publications

A case of coxsackie B virus infection leading to multi-organ inflammation: Myopericarditis and acute liver failure

A case of coxsackie B virus infection leading to multi-organ inflammation: Myopericarditis and acute liver failure

Miositis y poliartritis asociada a infección por virus Coxsackie B

Miosite e rabdomiólise na doença mão-pé-boca na infância

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