Acute liver failure and unique challenges of pediatric liver transplantation amidst a worldwide cluster of adenovirus-associated hepatitis

Banc-Husu, Anna M.; Moulton, Elizabeth A; Shiau, Henry; Sanchez, Luz Helena Gutierrez; Desai, Moreshwar S.; Cerminara, Dana; Buffaloe, Leanne M.; Valencia-Deray, Kristen; Galván, Nhu Thao Nguyen; Bhatnagar, Julu; Estetter, Lindsey; Rassaei, Negar; Reagan‐Steiner, Sarah; Wicker, Jason A.; Dunn, James J.; Allen, Carl E.; Patel, Kalyani R.; Harpavat, Sanjiv; Goss, J.; Leung, Daniel H.

doi:10.1016/j.ajt.2022.10.002

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Severe Acute Hepatitis Of Unknown Origin In Children1

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2023

2024

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Cited by 8 publications

(1 citation statement)

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“…As a disease with an aetiology and pathogenesis that remain unclear, no one knows when and where other outbreaks of this hepatitis will occur again in the future. Should the AHUO reappear, early diagnosis and prompt referral to centers with available liver transplantation facilities are in any case crucial due to possible deaths caused by the liver failure 12 …”

Section: Severe Acute Hepatitis Of Unknown Origin In Childrenmentioning

confidence: 99%

Emerging, re‐emerging and/or atypically behaving infectious diseases

Mandato¹,

Colucci²,

Vajro³

2023

Acta Paediatrica

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Section: Severe Acute Hepatitis Of Unknown Origin In Childrenmentioning

confidence: 99%

Emerging, re‐emerging and/or atypically behaving infectious diseases

Mandato¹,

Colucci²,

Vajro³

2023

Acta Paediatrica

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Erythrocyte‐Leveraged Oncolytic Virotherapy (ELeOVt): Oncolytic Virus Assembly on Erythrocyte Surface to Combat Pulmonary Metastasis and Alleviate Side Effects

Liu,

Zhang,

Huang

et al. 2023

Advanced Science

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Despite being a new promising tool for cancer therapy, intravenous delivery of oncolytic viruses (OVs) is greatly limited by poor tumor targeting, rapid clearance in the blood, severe organ toxicity, and cytokine release syndrome. Herein, a simple and efficient strategy of erythrocyte‐leveraged oncolytic virotherapy (ELeOVt) is reported, which for the first time assembled OVs on the surface of erythrocytes with up to near 100% efficiency and allowed targeted delivery of OVs to the lung after intravenous injection to achieve excellent treatment of pulmonary metastases while greatly improving the biocompatibility of OVs as a drug. Polyethyleneimine (PEI) as a bridge to assemble OVs on erythrocytes also played an important role in promoting the transfection of OVs. It is found that ELeOVt approach significantly prolonged the circulation time of OVs and increased the OVs distribution in the lung by more than tenfold, thereby significantly improving the treatment of lung metastases while reducing organ and systemic toxicity. Taken together, these findings suggest that the ELeOVt provides a biocompatible, efficient, and widely available approach to empower OVs to combat lung metastasis.

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Multiple drugs

2023

Reactions Weekly

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Acute liver failure and unique challenges of pediatric liver transplantation amidst a worldwide cluster of adenovirus-associated hepatitis

Cited by 8 publications

References 42 publications

Emerging, re‐emerging and/or atypically behaving infectious diseases

Emerging, re‐emerging and/or atypically behaving infectious diseases

Erythrocyte‐Leveraged Oncolytic Virotherapy (ELeOVt): Oncolytic Virus Assembly on Erythrocyte Surface to Combat Pulmonary Metastasis and Alleviate Side Effects

Multiple drugs

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