Acute liver failure after sevoflurane anesthesia in a pediatric patient

Barrezueta, Lorena Bermúdez; Gutiérrez, María-José; Rafael, Byron; Cristóbal, R. Herraiz; Vázquez, Asunción Pino

doi:10.1016/j.redare.2019.07.002

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…The prone position also decreases cardiac output and induces intra-operative hypotension [ 1 ]. Satomoto et al showed that prone-positioning support devices compressed the liver, resulting in postoperative liver failure [ 11 ]. The prone-positioning surgical bed has a device with 4-point support frames that supports the anterior thorax.…”

Section: Discussionmentioning

confidence: 99%

Delayed Emergence from Total Intravenous Anesthesia Following Posterior Spinal Correction and Fusion for Scoliosis: A Case Report

Hisatomi,

Fujiyoshi,

Shinotsuka

et al. 2023

Am J Case Rep

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Patient: Female, 15-year-old Final Diagnosis: Acute hepatic failure Symptoms: No clinical manifestations or complications Clinical Procedure: — Specialty: Anesthesiology • Neurology • Orthopedics and Traumatology Objective: Congenital defects/diseases Background: Postoperative acute liver failure, a complication following spine surgery, can cause delayed emergence from total intravenous anesthesia. Here, we report a case of acute severe postoperative liver failure following posterior spinal correction and fusion in a patient with congenital scoliosis. Case Report: A girl’s congenital scoliosis worsened, and posterior spinal correction and fusion was scheduled. General anesthesia was induced with sevoflurane, fentanyl, target-controlled-infusion with propofol, and rocuronium. General anesthesia was maintained using target-controlled-infusion with propofol and remifentanil. The operation was completed with no remarkable complications. The operative time was 516 min and the anesthesia time was 641 min in the prone position. Emergence from anesthesia was poor, and it took 68 min to remove the tracheal tube after discontinuation of the anesthetic agents. The patient was drowsy and was transferred to her room in a general ward without reporting any pain, nausea, or dyspnea. On postoperative day 1, the results of laboratory investigations were suggestive of acute liver failure; contrast-enhanced computed tomography revealed a poorly enhanced area in the umbilical portion of the left liver lobe portal vein, indicating ischemic liver damage. Although no additional treatment was administered for acute liver failure, the patient recovered over time, and laboratory values normalized. No other postoperative complications were observed, and the patient was discharged on postoperative day 21. Conclusions: Delayed emergence from general anesthesia may be due to acute liver failure following posterior spinal correction and fusion. There are several possible causes of postoperative liver failure, including anesthetics, prone position, and spinal surgery.

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Section: Discussionmentioning

confidence: 99%