Acute Leukemias Expressing p210-and p190-Type <i>bcr/ ab</i><i>l</i> mRNAs: Report of Two Cases and Review of the Literature

Abstract

We report two patients with acute leukemias who expressed two types of bcr/ αbl mRNA. The first case was an 8-year-old boy with acute mixed leukemia in whom the Ph¹ chromosome and p²¹⁰/p¹⁹⁰ types of bcr/αbl mRNAs were detected at diagnosis. The second case was a 39-year-old male with acute non-lymphocytic leukemia transformed from myelodysplastic syndrome (refractory anemia with excess of blasts). In the latter case, the p²¹⁰-type mRNA appeared after leukemic transformation, and the p¹⁹⁰-type transcript was detected only during the late stage when the Ph1 chromosome was first observed. The leukemias in these two patients were aggressive in their clinical courses. We conclude that the dual expression of p²¹⁰ and p¹⁹⁰ types of bcr/ αbl is a factor indicating a poor prognosis, and that, in some patients, p¹⁹⁰-type bcr/αbl may contribute to disease progression.

BCR-ABL-positive acute myeloid leukemia: a new entity? Analysis of clinical and molecular features

“…Eighteen cases of MDS that became BCR-ABL positive upon transformation into secondary AML were reported [3,11,[50][51][52][53][54][55][56][57][58][59][60]. In nine cases, information regarding the type of the BCR-ABL transcript was available.…”

Novel BCR–ABL transcript containing an intronic sequence insert in a patient with Philadelphia‐positive acute lymphoblastic leukaemia

“…A comparison of patients co‐expressing the p190‐ and p210‐encoding transcripts with those expressing only the p210‐encoding transcript revealed that the former showed significantly higher WBC counts and blast‐cell counts at the time of testing, as well as significantly higher WBC counts at diagnosis ( Lichty et al , 1998 ). It has also been reported that the dual expression of the p210 and p190 types of BCR–ABL is a factor indicating a poor prognosis and that p190‐type BCR–ABL may contribute to disease progression in some patients ( Yamashita et al , 1996 ). In the present case, the WBC count (4·160 × 10 9 /l) was normal at diagnosis and no co‐expression of p210 and p190 was observed at any time (p210 and p190 were each detected, but at different times).…”