Acute leukemia in the adult male.II. Natural history

Rivers, Shirley L.; Whittington, Richard; Gendel, Benjamin R.; Patno, Mary Ellen

doi:10.1002/1097-0142(196302)16:2<249::aid-cncr2820160216>3.0.co;2-2

Cited by 10 publications

(4 citation statements)

References 25 publications

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“…The frequency of specific symptoms (Table 111) is similar to that observed in other series (14,15,23) with a major exception. Whereas weakness or fatiguability was a complaint in only 19% of this series, others report a frequency of 61% ("anemia") (15), 78% (23), and 88% (14).…”

Section: Racesupporting

confidence: 84%

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Acute nonlymphocytic leukemia in 171 children

Choi

Simone

1976

Med. Pediatr. Oncol.

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The initial features, response to therapy, complications, cause of death, and prognostic factors of 171 consecutive children with ANLL are described and compated to historical data for adults with ANLL and for children with ALL. Major differences between children and adults with ANLL include a higher frequency of CNS leukemia and a lower frequency of early deaths in the children. The most important differences between children with ANLL and ALL are the absence of a peak age of incidence in ANLL and the far better response to therapy in ALL. Among features present at 100,000/mm3 or above, and no palpable hepatomegaly had significantly longer survivals, while patients with platelet counts below 10,000/mm3 had significantly shorter survivals. The frequency and duration of remission were significantly better with three protocols used since 1968 than previously. However, even with these protocols, the results were far from satisfactory, with a complete remission frequency of 66%, a median duration of hematological remission of 6 months, and a median duration of survival of 10 months. The striking contrast of these results in childhood ANLL with current results in childhood ALL underscores the need for novel, imaginative therapeutic approaches for ANLL.

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Section: Racesupporting

confidence: 84%

“…One explanation for this difference is that all 3 series consist mainly or solely of adults who are more likely to notice and express this symptom. Oropharyngeal symptoms, mainly sore throat, occurred in 18% in this series compared to 7% (23) and 13% (15) in others. In 5 patients leukemia was discovered by routine pretonsillectomy blood count.…”

Section: Racecontrasting

confidence: 45%

Acute nonlymphocytic leukemia in 171 children

Choi

Simone

1976

Med. Pediatr. Oncol.

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“…Since then, several more have been reported. In four reviews of acute leukemia analyzing 1250 patients, only nine cases (0.72%) of splenic rupture were identified [3,6,7,9]. Bauer et al [1] reviewed 53 cases described in the English literature; 21% of the patients had AML, but only one of these had an enlarged spleen.…”

Section: Introductionmentioning

confidence: 99%

Splenic rupture in a patient with acute myeloid leukemia undergoing peripheral blood stem cell transplantation

Kasper

Jones

Fujita

et al. 1999

Annals of Hematology

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Splenic rupture is a rare but well-recognized complication of hematological malignancies. Here, we present the case of a 22-year-old woman with the diagnosis of acute myeloid leukemia who was undergoing peripheral blood stem cell transplantation. On day + 10 she developed a hypovolemic shock due to rupture of her spleen and went to emergency laparotomy. This is the first report of splenic rupture during peripheral blood stem cell transplantation.

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“…RIVERS, et a1. 12 in 1971 mentioned that there was only one patient with rupture of the spleen in 120 patients of leukemia. The autopsy findings of a male who died of splenic rupture following acute leukemia are presented.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Rupture of the Spleen in Acute Myeloid Leukemia

Shinmoto

Uchida

Doi

et al. 1981

Acta Pathologica Japonica

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The results of an autopsy of an 80‐year‐old Japanese male with acute myeloid leukemia who died of spontaneous rupture of the spleen are reported. The patient was admitted because of anorexia, fatigue, weight loss, and multiple skin eruptions. Hematological examinations indicated a rapid increase in myeloblasts. The patient collapsed on the 28th hospital day, immediately after complaining of severe epigastralgia and vomiting. He died ten hours later. The autopsy revealed extensive leukemic infiltration of the bone marrows, spleen, lymph nodes, skin, and other internal organs. The spleen was enlarged and was ruptured in places at the hilar portion. Massive intraperitoneal hemorrhage from the rupture was the direct cause of death. The mechanisms of splenic rupture are discussed.

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Acute leukemia in the adult male.II. Natural history

Cited by 10 publications

References 25 publications

Acute nonlymphocytic leukemia in 171 children

Acute nonlymphocytic leukemia in 171 children

Splenic rupture in a patient with acute myeloid leukemia undergoing peripheral blood stem cell transplantation

Spontaneous Rupture of the Spleen in Acute Myeloid Leukemia

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