Acute Leukemia Characteristics are Different Around the World: the Mexican Perspective

Gómez‐Almaguer, David; Marcos-Ramírez, Edson R; Montaño-Figueroa, Efreen Horacio; Ruíz‐Argüelles, Guillermo J.; Best-Aguilera, Carlos; López-Sánchez, María del Carmen; Barrera-Chairez, Esperanza; López-Arrollo, José Luis; Ramos-Peñafiel, Christian Omar; León‐Peña, Andrés A.; González‐López, Elías Eugenio; Rivas-García, Pasiano; Tellez-Hinojosa, C.; León, Andrés Gómez‐De; Jaime‐Pérez, José Carlos

doi:10.1016/j.clml.2016.09.003

Cited by 37 publications

(27 citation statements)

References 39 publications

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“…That study did show that the median age of patients with ALL was similar to that of our cohort: 28 years (14–81) versus 31 (16–88), respectively. Likewise, we found that gender distribution was also similar: males (53.8%)–females (46.2%) versus males (53.3%)–females (46.6%), respectively . It is striking that no research group to date has reported a frequency of Ph + ‐ALL close to 25% as referred in developed societies ; the overall frequency of Ph + ‐ALL is estimated to be about 14% in Mexico.…”

Section: Discussionsupporting

confidence: 62%

Survival analysis of adult patients with ALL in Mexico City: first report from the Acute Leukemia Workgroup (ALWG) (GTLA)

et al. 2018

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Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by the clonal expansion of hematopoietic lymphoid progenitors. With new target therapies, the survival of adults with ALL has improved in the past few decades. Unfortunately, there are no large ALL patient series in many Latin American countries. Data from the Acute Leukemia Workgroup that includes five Mexico City referral centers were used. Survival was estimated for adult patients with ALL during 2009–2015. In total, 559 adults with ALL were included. The median age was 28 years; 67% were classified into the adolescent and young adult group. Cytogenetic information was available in 54.5% of cases. Of the 305 analyzed cases, most had a normal caryotype (70.5%) and Philadelphia‐positive was present in 16.7%. The most commonly used treatment regimen was hyper‐CVAD. In approximately 20% of cases, there was considerable delay in the administration of chemotherapy. Primarily refractory cases accounted for 13.1% of patients. At the time of analysis, 26.7% of cases had survived. The 3‐year overall survival was 22.1%. The main cause of death was disease progression in 228 (55.6%). Clinical and public health strategies are needed to improve diagnosis, treatment and survivorship care for adult with ALL. This multicentric report represents the largest series in Mexico of adult ALL patients in which a survival analysis and risk identification were obtained.

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Section: Discussionsupporting

confidence: 62%

Survival analysis of adult patients with ALL in Mexico City: first report from the Acute Leukemia Workgroup (ALWG) (GTLA)

et al. 2018

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“…Other factors such as environmental exposures and diet should be explored. Similar incidences of ALL and AML have been observed in Mexican adults, coinciding with other studies from Latin America and differing from reports from the USA, where AML is more common [15]. Interestingly, the median age of patients with AML is substantially lower in Mexicans than in Caucasians [15].…”

Section: Acute Myelogenous Leukemiasupporting

confidence: 69%

“…In our low-to-middle income population the peak incidence of AML has been observed 10 years earlier than in other countries, with a mean age at diagnosis of 32-43 years [15,24] compared to a median of 60-70 years in the USA or the UK [25,26]. As suggested by Jaime-Perez et al [24], this might be explained by the fact that older pa- tients are not referred to seeking care.…”

Section: Acute Myelogenous Leukemiamentioning

confidence: 54%

“…APL is the most common subtype of AML in Mexico, with an incidence of 35.5% [8,15], which is higher than the rate of around 5-13% reported in a Caucasian population [9] (Fig. 2).…”

Section: Acute Myelogenous Leukemiamentioning

confidence: 63%

“…Descriptive epidemiologic studies have reported a higher incidence of ALL in the Latin American population compared to other racial/ethnic groups, leading to a search for possible factors that make the Mexican population more susceptible to developing the disease than others [15]. In Mexico, no large-scale epidemiologic studies have been conducted in this population, but some studies suggest the incidence of ALL in Mexico is among the highest in the world [16][17][18][19].…”

Section: Geographical Differences In Mexicomentioning

confidence: 99%

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Geographic Hematology: Some Observations in Mexico

et al. 2018

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In 1963 Jean Bernard introduced the concept of “geographic hematology” and distinguished 2 branches, i.e., “ethnic hematology,” which deals with differences between populations, and “environmental hematology,” which considers factors such as food habits, infections, and others. Both of these branches have implications in the distribution of hematological diseases worldwide. In comparison with Caucasian populations, in Mexico a significantly higher prevalence of acute lymphoblastic, acute promyelocytic, and acute megakaryoblastic leukemias has been described. The rate of chronic myeloid leukemia seems to be as high as that reported in Caucasian populations, while other myeloproliferative neoplasias are significantly less frequent in Mexico. Significantly lower prevalences of hairy cell leukemia, chronic lymphocytic leukemia, multiple myeloma, and Waldenström’s macroglobulinemia have been reported from Mexico. Regrettably, the influence of drug companies interested in selling their new and expensive drugs has resulted in both overdiagnosis of some diseases and overidentification of the refractory forms of some of these conditions to justify the use of unnecessary drugs.

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Understanding factors limiting hematopoietic cell transplantation for acute myeloid leukemia patients in Mexico: a comprehensive analysis

Solís-Armenta,

Rodríguez-Rodríguez,

Hernández-Pérez

et al. 2024

Ann Hematol

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Acute Leukemia Characteristics are Different Around the World: the Mexican Perspective

Cited by 37 publications

References 39 publications

Survival analysis of adult patients with ALL in Mexico City: first report from the Acute Leukemia Workgroup (ALWG) (GTLA)

Survival analysis of adult patients with ALL in Mexico City: first report from the Acute Leukemia Workgroup (ALWG) (GTLA)

Geographic Hematology: Some Observations in Mexico

Understanding factors limiting hematopoietic cell transplantation for acute myeloid leukemia patients in Mexico: a comprehensive analysis

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