Acute leukaemia 1959-64: factors affecting prognosis.

Hardisty, R. M.; Till, Morwenna

doi:10.1136/adc.43.227.107

Cited by 61 publications

(23 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(3) Features associated with statistically significant differences in survival include the shorter survival of patients with platelet counts below 10,000/mm3 , and the longer survival of patients with initial leukocyte counts below 10,000/mm3, platelet counts of 100,000/mm3 or above, or no palpable hepatomegaly. A similar inverse relationship of prognosis and mass or extent of leukemia has been found in ALL (7,10,17,25,64).…”

Section: Prognostic Factorssupporting

confidence: 68%

See 1 more Smart Citation

Acute nonlymphocytic leukemia in 171 children

Choi

Simone

1976

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

The initial features, response to therapy, complications, cause of death, and prognostic factors of 171 consecutive children with ANLL are described and compated to historical data for adults with ANLL and for children with ALL. Major differences between children and adults with ANLL include a higher frequency of CNS leukemia and a lower frequency of early deaths in the children. The most important differences between children with ANLL and ALL are the absence of a peak age of incidence in ANLL and the far better response to therapy in ALL. Among features present at 100,000/mm3 or above, and no palpable hepatomegaly had significantly longer survivals, while patients with platelet counts below 10,000/mm3 had significantly shorter survivals. The frequency and duration of remission were significantly better with three protocols used since 1968 than previously. However, even with these protocols, the results were far from satisfactory, with a complete remission frequency of 66%, a median duration of hematological remission of 6 months, and a median duration of survival of 10 months. The striking contrast of these results in childhood ANLL with current results in childhood ALL underscores the need for novel, imaginative therapeutic approaches for ANLL.

show abstract

Section: Prognostic Factorssupporting

confidence: 68%

“…Mediastinal involvement, an important negative prognostic factor in childhood ALL (2,17,25), was found in three patients in this series; they survived 1, 10, and 48 months.…”

Section: Prognostic Factorsmentioning

confidence: 50%

Acute nonlymphocytic leukemia in 171 children

Choi

Simone

1976

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

show abstract

“…Part of this information has who have a high probability of treatment failure has been previously published [ 1,3 , 91. recently become possible through the definition of certain DEFIN,TION OF STUDY POPULAT,ON presenting prognostic factors. These include such clinical and/or biologic features as the level of the white blood Imunophenotyping studies, including cytoplasmic cell (WBC) count, age, degree of organomegaly, gender, and surface P chain expression to define pre-B or B cells, leukemic cell ploidy and/or karyotype, platelet count, respectively, and expression of E rosette receptors and/ presence of a mediastinal mass, race, cell morphology, or pan-T cell antigens to define T cell leukemia, were immunophenotype, rapidity of achieving remission, the performed on the lymphoblasts of all patients included in presence of initial central nervous system (CNS) leukemia, glucocorticoid receptor levels in blasts, and blast From the St. Jude Children's Research Hospital, Memphis, Tennessee PAS positivity [1][2][3][4][5][6][7][8][9][10][11][12]. Furthermore, the relative impor-(W.C.) Pediatric Oncology Group Statistical Office, Gainesville, tanCe of many Of these prognostic factors has been shown Florida (J.B.), University of Mississippi, Jackson (J.P.), M.D.…”

mentioning

confidence: 99%

Clinical and biologic features predict poor prognosis in acute lymphoid leukemias in children and adolescents: A pediatric oncology group review

Crist

Boyett²,

Pullen

et al. 1986

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

Although the prognosis of children with ALL has improved markedly, approximately one-half of children continue to relapse. Clinical and biologic features of ALL have been studied at the time of diagnosis and many of these features have been shown to predict the risk of relapse, permitting tailoring of therapy based on relapse hazard. Results of studies of the Pediatric Oncology Group (POG) detailed here demonstrate that high white blood cell (WBC) count at diagnosis, very young or older age within childhood, and the presence of a mediastinal mass or central nervous system leukemia predict a poor prognosis within the context of certain therapies. However, not only age and WBC count, but immunophenotype of ALL as well, were especially predictive of prognosis in these POG studies. The information reviewed here has special importance for the planning of clinical trials for children with ALL.

show abstract

“…Associations have been shown between various presenting features in patients with acute lymphoblastic leukaemia (Hardisty and Till, 1968 It is shown in Table III that after allowance has been made for the prognostic association with C.N.S. disease of lymph node enlargement there is no further significant association with enlargement of liver and spleen.…”

Section: Interactions Between Factorsmentioning

confidence: 99%