Acute left main coronary artery thrombosis due to cocaine use

Apostolakis, Efstratios; Tsigkas, Grigorios; Baikoussis, Nikolaos G; Koniari, Ioanna; Alexopoulos, Dimitrios

doi:10.1186/1749-8090-5-65

Cited by 11 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The acute use of cocaine has been demonstrated in the literature to result in coronary vasospasms but has not been well documented to result in thrombus formation and acute coronary syndrome (ACS) weeks after its effects have worn off. Coleman et al were the first to mention a relationship between ACS and cocaine use [ 1 , 2 ]. However, it has been reported that the risk of ACS is increased 24-fold during the first hour after cocaine use in patients with normal coronary arteries [ 1 , 3 ], thus making this case a very unusual presentation of ACS as a result of a history of cocaine usage.…”

Section: Introductionmentioning

confidence: 99%

Cocaine-Induced Delayed Myocardial Infarction Complicated by Apical Thrombus

et al. 2016

View full text Add to dashboard Cite

It is well demonstrated in the literature that cocaine use has been well linked to the formation of various forms of acute and chronic cardiovascular problems including but not limited to acute coronary syndromes. However, cocaine has been commonly associated with coronary vasospasms and less commonly with myocardial infarction and the formation of atrial thrombus. Through this case presentation, we illustrate the findings of a 35-year-old gentleman with history of cocaine use presenting with acute coronary syndrome and complicated by thrombus formation. Furthermore, through this report, we illustrate in a patient with no other risk factors and at a young age, how chronic cocaine use or even a history of usage may result in complications even weeks after its consumption.

show abstract

Section: Introductionmentioning

confidence: 99%

Cocaine-Induced Delayed Myocardial Infarction Complicated by Apical Thrombus

et al. 2016

View full text Add to dashboard Cite

show abstract

“…-гиперкоагулопатиями, обусловленными аутоим-мунными/системными поражениями с развитием STEMI у молодых женщин (54,5%) [33]; приемом контрацепти-вов; нефротическим синдромом; -употреблением амфетамина/наркотиков с развити-ем ИМ в 6% [8,19].…”

unclassified

“…Доминирующие предикторы риска ОКС у молодых мужчин: курение больше 1 пачки/день (77%), отягощен-ный семейный анамнез ИБС (55%), дислипидемия (44%), гиподинамия, избыточная масса тела/ожирение (39/20%), амфетамины/наркотики; стрессы/подростковая агрессия [7,8,13,18,26,43,47,50,58,61]. У молодых женщин к основным предикторам относят: ожирение, метаболиче-ский синдром, аутоиммунные/системные заболевания, прием контрацептивов, спонтанная диссекция КА при родах/в раннем послеродовом периоде.…”

unclassified

“…Ведущие пре-дикторы ОКС с поражением одной КА: курение, семей-ный анамнез ИБС, амфетамины/наркотики, гиподина-мия, стрессы/подростковая агрессия [7,8,13,18,43,44]. У молодых женщин доминируют: метаболический син-дром, аутоиммунные/системные заболевания, прием контрацептивов, спонтанная диссекция КА при родах/в раннем послеродовом периоде [12,17,21,33,37,38,46].…”

unclassified

See 1 more Smart Citation

Features of ischemic heart disease and myocardial revascularization in patients younger than 40 years

Abdullaev¹,

Mamedov²,

Багиров³

et al. 2015

Kardiol. serdechno-sosud. khir.

View full text Add to dashboard Cite

“…[20][21][22] Cocaine activates circulating platelets by increasing expression of platelet factor 4, thromboglobulin B, and P-selectin. 23,24 Elevated levels of C-reactive protein, von Willebrand factor, and fibrinogen also affect coagulation, with no compensatory increase in fibrinolytic activity.…”

Section: Prothrombotic Effectsmentioning

confidence: 99%

Rethinking Cocaine-Associated Chest Pain and Acute Coronary Syndromes

Finkel

Marhefka

2011

Mayo Clinic Proceedings

View full text Add to dashboard Cite

Every year more than 500,000 patients present to the emergency department with cocaine-associated complications, most commonly chest pain. Many of these patients undergo extensive work-up and treatment. Much of the evidence regarding cocaine's cardiovascular effects, as well as the current management of cocaine-associated chest pain and acute coronary syndromes, is anecdotally derived and based on studies written more than 2 decades ago that involved only a few patients. Newer studies have brought into question many of the commonly held theories and practices regarding the etiology, diagnosis, and treatment of this common clinical scenario. However, there continues to be a paucity of prospective, randomized trials addressing this topic as it relates to clinical outcomes. We searched PubMed for Englishlanguage articles from 1960 to 2011 using the keywords cocaine, chest pain, coronary arteries, myocardial infarction, emergency department, cardiac biomarkers, electrocardiogram, coronary computed tomography, observation unit, β-blockers, benzodiazepines, nitroglycerin, calcium channel blockers, phentolamine, and cardiomyopathy; including various combinations of these terms. We reviewed the abstracts to confirm relevance, and then full articles were extracted. References from extracted articles were also reviewed for relevant articles. In this review, we critically evaluate the limited historical evidence underlying the current teachings on cocaine's cardiovascular effects and management of cocaine-associated chest pain. We aim to update the reader on more recent, albeit small, studies on the emergency department evaluation and clinical and pharmacologic management of cocaine-associated chest pain. Finally, we summarize recent guidelines and review an algorithm based on the current best evidence. Proc. 2011;86(12):1198-1207 ACS = acute coronary syndrome; AHA = American Heart Association; CCB = calcium channel blockers; CCP = cocaine-associated chest pain; DBP = diastolic blood pressure; ECG = electrocardiography; ED = emergency department; HR = heart rate; MAP = mean arterial pressure; MI = myocardial infarction; PCI = percutaneous coronary intervention; SBP = systolic blood pressure; STEMI = ST-segment elevation myocardial infarction; TIMI = Thrombolysis in Myocardial Infarction E very year millions of Americans abuse cocaine, many of whom present to the emergency department (ED) with cocaine-related complications, most commonly chest pain. Unfortunately, much of the current thinking on cocaine and its cardiovascular effects is either anecdotally derived or based on small studies conducted more than 2 decades ago. Recently, newer studies have brought into question many of the commonly held theories and practices regarding the etiology, diagnosis, and management of cocaine-associated chest pain (CCP) and suspected myocardial ischemia. Mayo ClinWe searched PubMed for English-language articles from 1960 to 2011 using the keywords cocaine, chest pain, coronary arteries, myocardial infarction, emergency department, card...

show abstract

Acute left main coronary artery thrombosis due to cocaine use

Cited by 11 publications

References 10 publications

Cocaine-Induced Delayed Myocardial Infarction Complicated by Apical Thrombus

Cocaine-Induced Delayed Myocardial Infarction Complicated by Apical Thrombus

Features of ischemic heart disease and myocardial revascularization in patients younger than 40 years

Rethinking Cocaine-Associated Chest Pain and Acute Coronary Syndromes

Contact Info

Product

Resources

About