Acute Labyrinthitis Revealing COVID-19

Perret, Marie; Bernard, Angélique; Rahmani, Alan; Manckoundia, Patrick; Putot, Alain

doi:10.3390/diagnostics11030482

Cited by 32 publications

(46 citation statements)

References 14 publications

(9 reference statements)

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“…A cerebral MRI was performed in 10 of the 20 patients with audio-vestibular disorders. The neuroimaging revealed a clear inflammatory process of the inner ear in two of them, in one case bilateral, supporting the hypothesis of a direct cochlear and labyrinth damage (Degen et al 8 and Perret et al, 19 ).…”

Section: Discussionsupporting

confidence: 75%

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SARS-CoV-2 (COVID-19) and audio-vestibular disorders

Fancello

Hatzopoulos

Corazzi

et al. 2021

Int J Immunopathol Pharmacol

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To describe the audio-vestibular disorders related to the newly SARS-CoV-2 infection, including the possible ototoxicity side-effects related to the use of drugs included in the SARS-CoV-2 treatment protocols. A systematic review was performed according to the PRISMA protocol. The Medline and Embase databases were searched from March 1, 2020 to April 9, 2021. Initially the search yielded 400 manuscripts, which were reduced to 15, upon the application of inclusion criteria. Sensorineural hearing loss (SNHL) is the most frequent audio-vestibular symptom described, occurring alone or in association with tinnitus and vertigo. The etiopathogenesis of the inner ear disorders related to COVID-19 infection is still poorly understood. The number of reports of COVID-19 infections associated to audio-vestibular disorders is increasing; even if the quality of the studies available is often insufficient, audio-vestibular disorders should be considered as possible manifestations to be included among the symptoms of this infection.

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Section: Discussionsupporting

confidence: 75%

“…The database search identified 15 case reports or case series (level of evidence 4) for a total of 20 patients with established SARS-CoV-2 infection. 5 – 19 All patients reported a new-onset of audio-vestibular symptoms. The mean patient age was 42.4 ± 35.1 years, while the male to female ratio was 7:13.…”

Section: Resultsmentioning

confidence: 99%

SARS-CoV-2 (COVID-19) and audio-vestibular disorders

Fancello

Hatzopoulos

Corazzi

et al. 2021

Int J Immunopathol Pharmacol

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“…In addition to hearing loss, all reported cases noted additional symptoms, including tinnitus (36%), ear discomfort (15%), headache (14%), and nausea (12%) ( 5 ). Currently there are only few published case reports regarding the manifestation of otologic symptoms after COVID-19 infection, and no published correlations between hearing loss or other otologic symptoms after immunization with any available COVID-19 vaccines ( 6 ).…”

mentioning

confidence: 99%

Otologic Manifestations After COVID-19 Vaccination: The House Ear Clinic Experience

Wichova

Miller

Derebery

2021

Otology &Amp; Neurotology

103

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Objective: With the increasing numbers of COVID-19 vaccinations available there are some reports of new onset of otologic symptoms. We present our experience in recently vaccinated patients over a 30-day time frame. Study Design: Retrospective chart review. Setting: Tertiary otology ambulatory practice. Patients: All patients with available diagnostic codes, COVID-19 questionnaires and clinical notes. Interventions: Observational recordings. Main Outcome Measures: Within the same 30-day time period in 2019, 2020, and 2021, 1.6, 2.4, and 3.8% respectively, of all office visits were for patients with the diagnosis of new onset idiopathic sensorineural hearing loss (SNHL) without other underlying otologic diagnoses. In this time frame in 2021, 30 patients out of the 1,325 clinical visits had new or significantly exacerbated otologic symptoms that began shortly after COVID-19 vaccination. Specifically, 18 patients received Moderna and 12 patients received Pfizer vaccine. Their mean age was 60.9±13.8 years old; 11 were women and 19 men. The mean onset of symptoms was 10.18 ± 9 days post-vaccination. Symptoms included 25 patients (83.3%) with hearing loss, 15 (50%) with tinnitus, eight (26.7%) with dizziness, and five (16.7%) with vertigo. Eleven patients had previous otologic diagnoses, including six patients with Menière's disease, two with autoimmune inner ear disease (AIED), and three having both. Conclusions: There are no definite correlations to the COVID-19 pandemic or vaccination and new or worsened otologic symptoms. Vaccinated patients with new or exacerbated otologic symptoms should be promptly referred for evaluation. Suspected cases of post-vaccination otologic symptoms should be reported to the Center for Disease Control (CDC) vaccine adverse event reporting system (VAERS).

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“…Perret et al described a case of acute labyrinthitis and SSNHL ( 29 ); the patient was treated with oral prednisone and showed progressive recovery. The oral steroid treatment was effective also for treating the hearing impairment in a patient on peritoneal dialysis program who showed SSNHL as presenting symptom of SARS-CoV-2 infection ( 29 ). An improvement of the hearing capacity was also reported by Abdel Rhman and Abdel Wahid ( 30 ); in this case the patient was treated with intratympanic steroids.…”

Section: Resultsmentioning

confidence: 99%

Auditory Disturbances and SARS-CoV-2 Infection: Brain Inflammation or Cochlear Affection? Systematic Review and Discussion of Potential Pathogenesis

et al. 2021

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Patients affected by COVID-19 present a series of different symptoms; despite some of these are common, other less likely appear. Auditory symptoms seem to be less frequent, maybe because rarer or, alternatively, because they are underestimated during the clinical investigation. The hearing impairment might be related to the central or peripheral involvement of the auditory pathways; in particular, the likelihood of thrombosis might be one of the causes. To date, the prevalence of auditory symptoms such as sudden or progressive sensorineural hearing loss and tinnitus is unclear in COVID-19 patients. However, their presence might be an early sign of thrombosis or spread of the infection into the brain. In this systematic review of the literature we investigated the presence of auditory symptoms in COVID-19 patients and discussed their potential origin and causal relationship with SARS-CoV-2. Results showed that, despite rarely, auditory impairment can appear in patients with COVID-19 and should always be investigated for an early treatment and potential indicator of involvement of the central nervous system.

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Acute Labyrinthitis Revealing COVID-19

Cited by 32 publications

References 14 publications

SARS-CoV-2 (COVID-19) and audio-vestibular disorders

SARS-CoV-2 (COVID-19) and audio-vestibular disorders

Otologic Manifestations After COVID-19 Vaccination: The House Ear Clinic Experience

Auditory Disturbances and SARS-CoV-2 Infection: Brain Inflammation or Cochlear Affection? Systematic Review and Discussion of Potential Pathogenesis

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