Acute kidney injury secondary to traumatic rhabdomyolysis in a dog

Chen, Hilla; Aroch, Itamar; Segev, Gil

doi:10.1111/vec.12765

Cited by 11 publications

(23 citation statements)

References 39 publications

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“…The inclusion of antioxidant therapy in this case may have provided an additional benefit as suggested by other reports of severe rhabdomyolysis in dogs [19,23]. The free radical scavenger effects cited in these cases, however, were a product of the mechanistic spectrums of lidocaine and mannitol use rather than the S-adenosylmethionine administered in this patient.…”

Section: Case Reports In Veterinary Medicinementioning

confidence: 61%

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Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog

Smith

Wurlod

2020

Case Reports in Veterinary Medicine

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A 3-year-old female spayed rat terrier presented for hyperactivity and repetitive circling to the right of less than one-hour duration. On examination, the patient was dehydrated, hyperactive, and dysphoric. Laboratory tests initially revealed elevations in creatine kinase (CK) and aspartate aminotransferase (AST). Serial chemistries indicated significant progression of CK elevation to a maximum of 181,900 U/L on day 3 along with the development of profuse myoglobinuria. A urine drug screening test was positive for amphetamine metabolites. This patient was treated with sedatives, aggressive fluid diuresis, and antioxidants. The dog recovered uneventfully with no indicators of renal dysfunction based on serial blood chemistries and was discharged five days after presentation. Follow-up blood chemistries taken four days after discharge revealed near normalization of CK and resolution of myoglobinuria. This case report describes a particularly severe case of rhabdomyolysis associated with amphetamine toxicity and its successful treatment.

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Section: Case Reports In Veterinary Medicinementioning

confidence: 61%

“…Development of acute kidney injury associated with rhabdomyolysis has been described in the veterinary literature [16][17][18][19]. The mechanism of kidney injury proposed in rhabdomyolysis is multifactorial and includes some combination of renal hypoperfusion, ischemic damage, free radical formation, and acute tubular necrosis [8,9,18].…”

Section: Discussionmentioning

confidence: 99%

Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog

Smith

Wurlod

2020

Case Reports in Veterinary Medicine

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“…10 Rhabdomyolysis has also been previously associated with the development of AKI in people and dogs due to direct glomerular and renal tubular injury from myoglobin, as well as production of reactive oxygen species in the kidney. 7,11,12 Only in case 3 was myoglobinuria and intrinsic renal injury diagnosed.…”

Section: Discussionmentioning

confidence: 99%

Clothes dryer–induced heat stroke in three cats

Cudney

Wayne²,

Rozanski

2021

J Vet Emergen Crit Care

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Objective: To describe the clinical course of 3 cats successfully treated following clothes dryer-induced heat stroke.Case series summary: Three cats were treated after accidental clothes dryer-induced heat stroke. All cats fulfilled canine heat stroke criteria and showed evidence of heat injury, including neurological dysfunction, corneal and mucosal ulceration, and evidence of rhabdomyolysis. Coagulopathy, acute liver injury, acute kidney injury, cardiac dysfunction, and gastrointestinal signs were seen in cats with a longer duration of dryer exposure.New or unique information provided: Describes the management of cats after inadvertent clothes dryer-induced heat stroke.

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“…Rhabdomyolysis, the acute breakdown of skeletal muscle, is caused by severe traumatic or crushing injuries, hyperthermia, ischemia, drugs and toxins, snake or spider envenomation, electrolyte imbalances such as hypokalemia and hypophosphatemia, neoplasia, and infectious diseases 3–11 . Greyhounds and sled dogs appear more susceptible 11–14 .…”

Section: Introductionmentioning

confidence: 99%

Acute nontraumatic rhabdomyolysis in a Greyhound after albuterol toxicosis

Granfone

Walker

2021

J Vet Emergen Crit Care

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Objective To describe the clinical features of rhabdomyolysis due to albuterol toxicosis in a Greyhound. Case summary A 4‐year‐old neutered male Greyhound was presented for albuterol toxicosis leading to severe hypokalemia and respiratory paralysis. After 3 hours of mechanical ventilation, pigmenturia and marked enlargement, firmness, and pain of the left thigh muscles were noted. Severe hyperkalemia and cardiac arrhythmias were identified after turning the patient. After discontinuation of mechanical ventilation, other muscles became involved, and the patient developed acute kidney injury and concern for multiple organ dysfunction syndrome over the next 5 days. On day 6, the patient was euthanized, and necropsy revealed myocardial and skeletal muscle necrosis, myoglobinuria, and acute tubular degeneration. New or unique information provided To the authors’ knowledge, this is the first case of albuterol toxicosis leading to rhabdomyolysis.

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Acute kidney injury secondary to traumatic rhabdomyolysis in a dog

Abstract: This is the first report of a dog with crush syndrome with secondary myoglobinuria and AKI.

Cited by 11 publications

References 39 publications

Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog

Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog

Clothes dryer–induced heat stroke in three cats

Acute nontraumatic rhabdomyolysis in a Greyhound after albuterol toxicosis

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