Acute kidney injury prevalence in patients with colorectal cancer undergoing surgery with curative intent

Kozłowski, Leszek; Małyszko, Jolanta

doi:10.5114/wo.2021.111057

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…However, Rödel et al reported in their study an increase in serum creatinine levels in 16% of studied rectal cancer patients who received neoadjuvant concurrent chemoradiotherapy followed by 4 cycles adjuvant XELOX [24]. These results are also in agreement with another Polish study [25].…”

Section: Discussionsupporting

confidence: 76%

Prevalence and risk factors of Acute kidney injury after colorectal cancer surgery

Abdulgalil,

Metwally,

Zuhdy

et al. 2024

Preprint

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Introduction: Postoperative AKI (PO-AKI) is a sentinel postsurgical event that is highly correlated with both short and long-term adverse outcomes. Objectives: this work aimed to study the prevalence and risk factors of PO-AKI after colorectal cancer (CRC) surgery in Egyptian patients. Methods: Data of patients with CRC who underwent surgery over the previous five years was retrieved from the medical system. The Incidence of PO-AKI was recorded and its possible risk factors, also the impacts of AKI on patients' outcomes and mortality were included. Results: Data of 562 cases were recruited. PO-AKI was detected in 10.3% of patients. Significant risk factors included intraoperative hypotension (p = 0.023), sepsis (p= 0.003), hypoalbuminemia (p= 0.014), amount of intraoperative-bleeding (p= 0.050), neoadjuvant therapy (p= 0.023) and preoperative CKD (p=0.05). Post-chemotherapy AKI was observed in 18.7% of the treated patients. Significant risk factors were previous CKD (p=0.002) and chemotherapy type (p<0.001) mainly affecting those who received XILIRI and FOLFIRI. The overall survival was significantly worse in those who developed postsurgical or post-chemotherapy AKI (p < 0.001). Conclusions: AKI affects slightly more than a fourth of CRC patients after surgery and/or chemotherapy. Risk factors include CKD, hypoalbuminemia, neoadjuvant and Irinotecan based chemotherapy, intraoperative bleeding and/or hypotension. Most injuries are stage I; however, associated with worse overall survival.

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Section: Discussionsupporting

confidence: 76%

Prevalence and risk factors of Acute kidney injury after colorectal cancer surgery

Abdulgalil,

Metwally,

Zuhdy

et al. 2024

Preprint

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“…Colorectal cancer ranks fourth in incidence and second in mortality among all types of cancer worldwide, posing a serious threat to patient's health and safety [54,55,56]. Currently, the preferred treatment for colorectal cancer patients is radical surgery to remove the lesion [57,58,59]. Laparoscopic surgery, which allows for the visualization of surrounding tissues, nerves, blood vessels, and ureters, helps minimize damage to surrounding tissues and has shown signi cant clinical outcomes [60].…”

Section: Discussionmentioning

confidence: 99%

New Insights into Risk Factors for Postoperative Infections in Colorectal Cancer

Li,

Zhao,

Liu

2024

Preprint

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Background Postoperative incision infections are a significant concern in colorectal cancer surgery, impacting patient recovery and well-being. Identification of key risk factors for infection following colorectal cancer surgery is crucial for improving patient outcomes. Methods A meta-analytical approach was employed to analyze studies published from January 2015 to December 2022, focusing on variables such as body mass index, diabetes, albumin levels, malnutrition, and surgical duration to assess their association with postoperative infection incidence in colorectal cancer patients. Results Analysis of eleven high-quality studies revealed that elevated body mass index, diabetes, low albumin levels, malnutrition, and longer surgical durations were linked to an increased risk of postoperative incision infections. Conversely, laparoscopic procedures demonstrated potential for reducing infection risks. Conclusions Effective preoperative risk assessment and management are vital in preventing postoperative incision infections in colorectal cancer patients. These findings offer actionable insights for clinicians to optimize patient prognoses and enhance overall quality of life outcomes.

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“…As the median age is above 65 years at the time of CRC diagnosis in many studies, surgery is often performed in elderly patients with multimorbidities [ 26 , 27 , 28 , 29 ]. It may explain the wide range of complications, including CKD, acute kidney injury or acute kidney disease [ 30 , 31 ]. It should be taken into account the heterogeneity of the available studies in regard to the procedures, urgency of surgery, neoadjuvant treatment concomitant medication, and imaging studies.…”

Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease Prevalence in Patients with Colorectal Cancer Undergoing Surgery

et al. 2022

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Colorectal cancer (CRC) is a common and mortal disease. Chronic kidney disease (CKD) is the relatively common comorbidity among cancer patients affecting the available therapy and outcomes. However, data on prevalence of CKD in patients with CRC undergoing surgery is limited. The aim of the study was to evaluate the prevalence of CKD in a cohort of 560 consecutive patients with CRC undergoing surgical treatment with curative intent. Neoadjuvant therapy in a form of radiotherapy or radiochemotherapy was administered before the surgery in 67 patients and in 86 patients, respectively. Results: CKD was reported in 10%, diabetes in 25%, and hypertension in 60%, while anemia was reported in 47%. The patients with CKD were more likely to be older and anemic with higher serum CRP, which reflects a general inflammatory state. Relative to patients without this therapy, patients undergoing neoadjuvant radiochemotherapy were older, had significantly lower eGFR and albumin, and higher creatinine, aspartate aminotransferase and INR, before the surgery. All CKD patients, except two, were older than 65 years of age. Conclusions: In order to ensure the best possible outcomes, CKD should be diagnosed and treated appropriately in oncology patients to prevent complications, so they may continue their therapy with the least interruption or discontinuation of treatment.

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Acute kidney injury prevalence in patients with colorectal cancer undergoing surgery with curative intent

Cited by 5 publications

References 26 publications

Prevalence and risk factors of Acute kidney injury after colorectal cancer surgery

Prevalence and risk factors of Acute kidney injury after colorectal cancer surgery

New Insights into Risk Factors for Postoperative Infections in Colorectal Cancer

Chronic Kidney Disease Prevalence in Patients with Colorectal Cancer Undergoing Surgery

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