Acute kidney injury

Joannidis, Michael; Meersch-Dini, Melanie; Forni, Lui G.

doi:10.1007/s00134-023-07061-4

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Moreover, patients with AKI face a potential risk of developing chronic kidney disease (CKD) ( Kurata and Nangaku, 2023 ). Despite considerable advancements in the detection and treatment of AKI, along with research into its pathophysiological mechanisms, the morbidity and mortality rates of AKI continue to rise ( Fortrie et al, 2019 ; Joannidis et al, 2023 ; Kashani et al, 2023 ; Zhong et al, 2023 ). Immunopathophysiological responses can lead to disturbances in both macrocirculatory and microcirculatory functions in the kidney, resulting in functional impairment ( Okusa et al, 2017 ; Inoue et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Bibliometric and visual analysis of immunisation associated with acute kidney injury from 2003 to 2023

Chen,

Hu,

et al. 2024

Front. Pharmacol.

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ObjectiveThis study aims to conduct a detailed bibliometric and visual analysis of acute kidney injury (AKI) and immune-related research conducted over the past two decades, focusing on identifying emerging trends and key areas of interest.MethodsThe Web of Science Core Collection (WoSCC) was utilised for the meticulous examination of various parameters including publication volume, authorship, geographic distribution, institutional contributions, journal sources, prevalent keywords and citation frequencies. Data were intricately visualised and interpreted using VOSviewer, CiteSpace and Excel 365 software.ResultsAnalysis of the WoSCC database revealed 3,537 articles on AKI and immunisation, originating from 94 countries and regions, involving 3,552 institutions and authored by 18,243 individuals. Notably, the top five countries contributing to this field were the United States, China, Germany, Italy and the United Kingdom, with the United States leading with 35.76% of total publications. Among the 3,552 contributing institutions, those in the United States were predominant, with Harvard University leading with 134 papers and 3,906 citations. Key journals driving productivity included Frontiers in Immunology, Kidney International, Journal of the American Society of Nephrology and International Journal of Molecular Sciences, with Kidney International being the most cited, followed by Journal of the American Society of Nephrology and New England Journal of Medicine. Prominent authors in the field included Ronco Claudio, Okusa Mark D and Anders, Hans-Joachim. Co-citation clustering and timeline analysis highlighted recent research foci such as COVID-19, immune checkpoint inhibitors, regulated necrosis, cirrhosis and AKI. Keyword analysis identified “inflammation,” “ischaemia-reperfusion injury,” “sepsis,” “covid-19,” and “oxidative stress” as prevalent terms.ConclusionThis study provides the first bibliometric analysis of AKI and immune research, offering a comprehensive overview of research hotspots and evolving trends within the field.

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Section: Introductionmentioning

confidence: 99%

Bibliometric and visual analysis of immunisation associated with acute kidney injury from 2003 to 2023

Chen,

Hu,

et al. 2024

Front. Pharmacol.

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Lactate metabolism and acute kidney injury

Li,

Ren,

Shi

et al. 2024

Chinese Medical Journal

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Acute kidney injury (AKI) is a common clinically critical syndrome in hospitalized patients with high morbidity and mortality. At present, the mechanism of AKI has not been fully elucidated, and no therapeutic drugs exist. As known, glycolytic product lactate is a key metabolite in physiological and pathological processes. The kidney is an important gluconeogenic organ, where lactate is the primary substrate of renal gluconeogenesis in physiological conditions. During AKI, altered glycolysis and gluconeogenesis in kidneys significantly disturb the lactate metabolic balance, which exert impacts on the severity and prognosis of AKI. Additionally, lactate-derived posttranslational modification, namely lactylation, is novel to AKI as it could regulate gene transcription of metabolic enzymes involved in glycolysis or Warburg effect. Protein lactylation widely exists in human tissues and may severely affect non-histone functions. Moreover, the strategies of intervening lactate metabolic pathways are expected to bring a new dawn for the treatment of AKI. This review focused on renal lactate metabolism, especially in proximal renal tubules after AKI, and updated recent advances of lactylation modification, which may help to explore potential therapeutic targets against AKI.

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Acute kidney injury

Cited by 2 publications

References 15 publications

Bibliometric and visual analysis of immunisation associated with acute kidney injury from 2003 to 2023

Bibliometric and visual analysis of immunisation associated with acute kidney injury from 2003 to 2023

Lactate metabolism and acute kidney injury

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