Acute Kidney Injury in Pregnancies Complicated by Late-Onset Preeclampsia with Severe Features

Rodriguez, Aldeboran N.; Nelson, David B.; Spong, Catherine Y.; McIntire, Donald D.; Reddy, Meghana T; Cunningham, F. Gary

doi:10.1055/s-0042-1749632

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Early detection and treatment of AKI can improve mother-fetus outcomes. Medical practitioners must understand the characteristics, risks, and treatments for AKI in pregnancies degraded by pre-eclampsia or HELLP syndrome [4].…”

Section: Background Of the Studymentioning

confidence: 99%

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Acute Kidney Injury in Pregnancies Complicated With Pre-Eclampsia or Hellp Syndrome: A Retrospective Study.

Suman

Sinha

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BackgroundThis study aimed to determine the prevalence of Acute Kidney Injury (AKI) and its clinical characteristics and outcomes among pregnant women in the Indian state of Bihar with pre-eclampsia or Hemolysis, Elevated Liver Enzymes, and Low Platelet (HELLP) syndrome. MethodsA retrospective unit study was conducted at tertiary care facilities in Bihar on women diagnosed with pre-eclampsia or HELLP syndrome during pregnancy. All the gathered data, including demographic information, obstetric history, test results, and maternal and foetal outcomes, originated from medical records. A statistical analysis was conducted on the incidence rates of AKI and the associated risk variables. ResultsOne hundred pregnant women participated in this study, in which 15% of pregnant participants with pre-eclampsia or HELLP syndrome, suffered with acute kidney damage. Acute kidney damage risk factors include maternal age over 35, first-time pregnancy, severe hypertension, and delayed antihypertensive drug initiation. Acute renal injury caused respiratory distress, pulmonary oedema, and dialysis in mothers. AKI-compromised pregnancies exhibited more significant rates of preterm birth, low birth weight, and perinatal mortality. ConclusionPregnant women in Bihar with pre-eclampsia or HELLP syndrome have a significant rate of AKI. First, identify risk variables and then quickly apply management techniques to avoid and control AKI in this population. Prenatal care, regular blood pressure monitoring, and early antihypertensive treatment are crucial to lowering AKI prevalence and severity. RecommendationFor improved management of AKI in expectant women with pre-eclampsia or HELLP syndrome, blood pressure and urine protein levels should be routinely monitored as part of prenatal care. Protect against AKI by initiating antihypertensive treatment promptly and promoting interdisciplinary collaboration for the overall management of high-risk pregnancies. Promote research and surveillance to evaluate and improve current AKI preventive measures, and establish long-term follow-up programmes to assess postpartum kidney health.

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Section: Background Of the Studymentioning

confidence: 99%

“…Additionally, oliguria, a decrease in urine production, exhaustion, and abdominal pain are potential symptoms [9,10]. It is possible to initiate intervention and therapy earlier if these clinical indicators are detected reliably.…”

Section: Clinical Performancementioning

confidence: 99%

Acute Kidney Injury in Pregnancies Complicated With Pre-Eclampsia or Hellp Syndrome: A Retrospective Study.

Suman

Sinha

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Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review

Modzelewski

Siarkowska

Pajurek-Dudek

et al. 2023

IJMS

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This systematic review was conducted to gather evidence of preeclampsia occurring before the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the development of the disease. In the three cases of preeclampsia before the 20th week of gestation presented in the authors’ material, all pregnancies ended up with IUFD, and the SFlt-1/PLGF ratios were significantly elevated in all women. Eligible publications were identified with searches in the PubMed, Embase, Scopus, and Web of Science databases. No date or language restrictions were made. All original peer-reviewed scientific reports were included. A total of 30 publications were included in the final report, including case reports and case series. No other publication types regarding this issue were identified. In the literature, 34 cases of preeclampsia with onset occurring before the 20th week of gestation were identified, for a final total of 37 cases. Live births were reported in 5 cases (10.52%), and there were 9 intrauterine fetal demises (24.32%), and 23 terminations of pregnancy (62.16%). Preeclampsia before the 20th week of gestation is rare but can occur. We collected all available evidence regarding this phenomenon, with 37 cases reported worldwide. We call for large-scale cohort or register-based studies to establish revised definitions or develop new ones regarding the currently unrecognized very early onset preeclampsia.

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Acute Kidney Injury in Pregnancies Complicated by Late-Onset Preeclampsia with Severe Features

Cited by 2 publications

References 27 publications

Acute Kidney Injury in Pregnancies Complicated With Pre-Eclampsia or Hellp Syndrome: A Retrospective Study.

Acute Kidney Injury in Pregnancies Complicated With Pre-Eclampsia or Hellp Syndrome: A Retrospective Study.

Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review

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