Acute Kidney Injury in Multisystem Inflammatory Syndrome in Children (MIS-C): a Case Report

Lee, Melissa; Hilado, Mark A.; Sotelo, Sarah; Opas, Lawrence; Im, Daniel D.

doi:10.1007/s42399-020-00647-9

Cited by 15 publications

(14 citation statements)

References 9 publications

(10 reference statements)

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“…Moreover, BUN and creatinine increased but CRRT deferred in the setting of dehydration and intravenous therapy resulted in significant improvement. She also had skin rash and had antibodies to COVID-19 similar to our patient (9). The optimum time for CRRT is 16.5 hr of AKI and mortality is lower than the interval of 28, 60, and 90 hr (10).…”

Section: Discussionsupporting

confidence: 64%

A Child with Multiple Inflammatory Syndrome in Children, Stroke and Cardiac Insufficiency

et al. 2021

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: Multiple inflammatory syndrome in children (MIS-C) is a multisystem inflammatory disease following COVID-19 in children. This disease occurs a few weeks after COVID-19. A child with this condition develops a cytokine release cascade that results in organ damage. The involved organs include the heart, lungs, brain, gastrointestinal tract, and central nervous system. Fever is present in all patients and Kawasaki-like symptoms are one of the common features in these children. In this article, we introduce a child with MIS-C who has skin, gastrointestinal, neurological, and renal symptoms and has been hospitalized in the PICU.

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Section: Discussionsupporting

confidence: 64%

A Child with Multiple Inflammatory Syndrome in Children, Stroke and Cardiac Insufficiency

et al. 2021

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“…In summary, the pathogenesis of renal involvement in COVID-19 is probably multifactorial, and proposed mechanisms include direct infection of renal parenchyma via ACE2 receptors which are highly present in kidney tissue ( 43 , 52 , 59 ), microvascular injury caused by cytokine storm and/or hypercoagulability ( 25 , 43 , 51 , 59 ), and circulatory shock ( 4 , 48 , 49 ).…”

Section: Discussionmentioning

confidence: 99%

Hematuria as an Early Sign of Multisystem Inflammatory Syndrome in Children: A Case Report of a Boy With Multiple Comorbidities and Review of Literature

et al. 2021

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Introduction: While the clinical course of SARS-CoV-2 infection seems to be milder or asymptomatic within the pediatric population, growing attention has been laid to the rare complication elicited by virus, multisystem inflammatory syndrome in children temporarily associated with COVID-19 (MIS-C). Published definition and criteria of MIS-C include persistent fever, multisystem involvement, and elevated markers of inflammation, without obvious microbial inflammation or other plausible diagnosis. However, the aim of this case report is to emphasize the diversity of symptoms of MIS-C, beyond the defined criteria.Case Presentation: We present a 10-year-old boy with 8p23.1 microdeletion syndrome and multiple comorbidities who initially came to our attention due to hematuria, persistent fever, rash, and elevated markers of inflammation. Within the next 2 days, his condition worsened despite the broad-spectrum antibiotic therapy. Assuming his past history of SARS-CoV-2 exposure, MIS-C was suspected. A high level of clinical suspicion was further supported by significant clinical features (vomiting, abdominal pain, conjunctivitis, arrhythmia, and mild left ventricular systolic dysfunction with pleural effusion) along with laboratory findings (elevated ESR, CRP, proBNP, D-dimers and fibrinogen, positive IgG SARS-CoV-2 antibodies, and negative microbiological cultures). The patient was given intravenous immunoglobulin (IVIG) and began to show instantaneous clinical and laboratory improvement.Conclusion: Despite numerous reports of MIS-C cases in children, there are still many uncertainties regarding the clinical presentation and laboratory findings, as well as mechanisms beyond this intriguing disorder. In our case, for the first time hematuria is reported as an early symptom of MIS-C. We strongly believe that reporting various manifestations and outcomes in MIS-C patients will lead to improved diagnosis, treatment, and overall understanding of this novel inflammatory condition.

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“…We have read with great interest the manuscript entitled “Acute Kidney Injury in Multisystem Inflammatory Syndrome in Children (MIS-C): a Case Report” [ 1 ].…”

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confidence: 99%