Introduction. The aim of this study was to determine the epidemiological and
clinical characteristics of hemorrhagic fever with renal syndrome in
Vojvodina from 2008-2015 and to examine the factors associated with acute
renal failure and hemorrhagic syndrome. Material and Methods. Data were
extracted from medical records spanning 2008 to 2015, including demographic,
epidemiological, clinical, and laboratory findings at hospital admission, as
well as the course and outcome of treatment. The study investigated the
correlation between disease incidence and climate, focusing on acute renal
failure, its risk factors, the incidence of hemorrhagic syndrome, and
factors influencing hospital stay duration. Results. The highest incidence
for hemorrhagic fever with renal syndrome was recorded in 2014, with a rate
of 0.5 per 100.000 inhabitants. Acute renal failure was observed in 40% of
patients, while mild manifestations of hemorrhagic syndrome were noted in
46.7% of cases. Factors contributing to acute renal failure included lumbar
pain (p=0.005), creatinine concentrations (p=0.011), and Simplified Acute
Physiology score (p=0.013). The average length of hospitalization was 10
days (range 7-13 days) and was correlated with increased leukocytosis
(p=0.028; ?=0.566), higher C-reactive protein values (p=0.014; ?=0.686),
lower serum sodium levels (p=0.009; ?=0.772), higher serum creatinine
concentrations (p=0.002; ?=0.742), the Sequential Organ Failure Assessment
score (p=0.013; ?=0.612) and the Simplified Acute Physiology score (p=0.023;
?=0.582). Conclusion. Climatic factors are associated with the incidence of
hemorrhagic fever with renal syndrome. The overall outcome of the disease
was favorable.