Acute Kidney Injury in Children with Diabetic Ketoacidosis: Risk Factors and Outcome

Mishra, Om P.; Prasad, Rajniti

doi:10.1007/s12098-021-03762-0

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…This rapid recovery may explain the lack of any significant difference in the clinical improvement of patients with AKI when compared to those without AKI. Similar to the present study, Mishra et al found no correlation between the severity of DKA and that of AKI 16 , and again, similar to our findings, there have been previous studies reporting that the presence of AKI did not affect the duration of hospitalization or the resolution of metabolic acidosis 16 . In the present study, only the first episode of DKA in patients with newly diagnosed DM was evaluated, and the resolution time was recorded as 21.04±7.8 h, compared to the resolution time of 16.25 h reported by Ying Wei et al 10 .…”

Section: Discussionsupporting

confidence: 93%

The effect of serum biochemical parameters on clinical prognosis in children presenting with diabetic ketoacidosis

Isik,

Aydin

2024

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The aim of this study was to determine whether diabetes mellitus has a high risk of diabetic ketoacidosis-related complications. Biochemical parameters affect the resolution time of diabetic ketoacidosis. METHODS: The present study is based on a retrospective evaluation of the records of patients who presented to the Pediatrics Clinic of Adiyaman University Hospital between January 1, 2017, and October 1, 2022, with a diagnosis ofdiabetic ketoacidosis. The demographic characteristics, serum biochemical parameters, blood gas results, and time to transition to subcutaneous insulin therapy were all recorded. RESULTS: This study included 49 (49%) female and 51 (51%) male patients aged 1–17 years (mean age: 9.05±4.33 years). The average time to clinical improvement of the sample, that is, transition to subcutaneous insulin therapy, was 21.04±7.8 h. An evaluation of the presence of acute kidney injury based on serum urea and creatinine levels and eGFR values revealed no significant effect on the rate of clinical recovery (respective p-values: p=0.076, p=0.494, and p=0.884). A univariate analysis identified blood glucose (p=0.025), blood gas pH (p<0.001), and blood bicarbonate (p=0.004) values as prognostic factors, while a multivariate analysis revealed pH values had an independent and significant effect on the resolution time of diabetic ketoacidosis. CONCLUSION: Serum glucose, pH, and bicarbonate levels are the most important determinants of clinical prognosis in patients with diabetic ketoacidosis. These findings can serve as a guide for clinicians in the follow-up and treatment of such patients.

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Section: Discussionsupporting

confidence: 93%

The effect of serum biochemical parameters on clinical prognosis in children presenting with diabetic ketoacidosis

Isik,

Aydin

2024

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

Acute Kidney Injury in Children with Diabetic Ketoacidosis: Risk Factors and Outcome

Cited by 2 publications

References 6 publications

The effect of serum biochemical parameters on clinical prognosis in children presenting with diabetic ketoacidosis

The effect of serum biochemical parameters on clinical prognosis in children presenting with diabetic ketoacidosis

Predictive ability of renal angina index alone or in combination with biomarkers for detection of acute kidney injury in children

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