Acute kidney injury in AIDS: frequency, RIFLE classification and outcome

Júnior, Geraldo B. Silva; Libório, Alexandre Braga; Mota, Rosa Maria Salani; Abreu, Krasnalhia Lívia S.; Silva, A.E.B.; Araújo, Sônia Maria Holanda Almeida; Daher, Elizabeth De Francesco

doi:10.1590/s0100-879x2010007500100

Cited by 9 publications

(6 citation statements)

References 30 publications

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“…In total, 58 studies were eligible for inclusion. Of these, nine investigated platelet function in AKI patients, 28 29 30 52 53 54 55 56 57 46 studies examined platelet count only 23 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 and 3 investigated mean platelet volume. 103 104 105 Thirty-two studies were set in an ICU and twenty-six were set in a medical ward.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-nine studies (28 including adults and 1 including children) investigated platelet count or thrombocytopenia prevalence in ICU patients, 28 52 53 54 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 and 24 studies included medical ward patients with either lupus nephritis ( n = 1), 93 rifampicin treatment ( n = 1), 94 snake bite ( n = 2), 91 92 decompensated liver cirrhosis ( n = 3), 30 57 95 infectious diseases ( n = 8), 83 84 85 86 87 88 89 90 or AKI of mixed origin ( n = 9). 23 29 96 97 98 99 100 101 102 Further, three studies investigated mean platelet volume in AKI patients, of which two were set in an ICU 103 104 and one was set in a medical ward.…”

Section: Resultsmentioning

confidence: 99%

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Platelet Function in Acute Kidney Injury: A Systematic Review and a Cohort Study

Jensen

Hviid

Hvas

et al. 2022

Semin Thromb Hemost

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Acute kidney injury (AKI) patients have increased bleeding risk, which could be partially due to acquired platelet dysfunction. We conducted a systematic review and a cohort study to investigate platelet function and count in AKI and their association with AKI-related bleeding and mortality. Through a systematic literature search in PubMed and Embase, we identified 9 studies reporting platelet function and 56 studies reporting platelet count or platelet indices in AKI patients. Overall, platelet aggregation was reduced in AKI patients in nonintensive care unit (ICU) settings but not in ICU settings, except that reduced aggregation was associated with renal replacement therapy. Thrombocytopenia in AKI was frequent and often predictive of mortality. In our cohort study, we prospectively included 54 adult ICU patients who developed AKI within 24 hours of ICU admission and 33 non-AKI ICU controls. Platelet function was measured with light transmission aggregometry and flow cytometry. AKI patients bled more frequently than non-AKI patients (p = 0.04), and bleeding was associated with increased 30-day mortality in AKI (p = 0.02). However, platelet function was not different between AKI and non-AKI patients (aggregation: all p > 0.52; flow cytometry: all p > 0.07) and platelet function was not associated with bleeding in AKI. In conclusion, a reduced platelet count is frequent in AKI, but the literature on platelet function in AKI is sparse. In a cohort study, we demonstrated that patients with AKI within 24 hours of ICU admission exhibited increased bleeding tendency but this was not associated with reduced platelet function.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Platelet Function in Acute Kidney Injury: A Systematic Review and a Cohort Study

Jensen

Hviid

Hvas

et al. 2022

Semin Thromb Hemost

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“…Tubular cells are rich in mitochondria, and changes in mitochondria of the tubules are an important indicator of the occurrence and development of renal diseases ( 149 ). AKI can be caused by various factors, such as bacterial infection, drugs and sepsis ( 150 ). At present, the clinical diagnosis of AKI primarily depends on the detection of elevated serum creatinine levels and decreased urine output ( 151 ).…”

Section: Diseases and Protein Acetylation And Deacetylationmentioning

confidence: 99%

Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review)

Xia

et al. 2020

Exp Ther Med

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Cells primarily rely on proteins to perform the majority of their physiological functions, and the function of proteins is regulated by post-translational modifications (PTMs). The acetylation of proteins is a dynamic and highly specific PTM, which has an important influence on the functions of proteins, such as gene transcription and signal transduction. The acetylation of proteins is primarily dependent on lysine acetyltransferases and lysine deacetylases. In recent years, due to the widespread use of mass spectrometry and the emergence of new technologies, such as protein chips, studies on protein acetylation have been further developed. Compared with histone acetylation, acetylation of non-histone proteins has gradually become the focus of research due to its important regulatory mechanisms and wide range of applications. The discovery of specific protein acetylation sites using bioinformatic tools can greatly aid the understanding of the underlying mechanisms of protein acetylation involved in related physiological and pathological processes. Contents 1. Introduction 2. Discovery and concepts of protein acetylation and deacetylation 3. Diseases and protein acetylation and deacetylation 4. Protein acetylation and deacetylation in stem cells 5. Tools to predict acetylation sites 6. Conclusions and prospects

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“…The reported incidence of AKI in HIV-infected patients is also variable depending on the setting. Although the majority of studies are retrospective, with different patient characteristics and follow-up times, the lowest incidence rate of AKI is reported in ambulatory patients, ranging from 5.7 to 9.4% [22][23][24] and up to 35% in developing countries [25], followed by hospitalized patients [8,[26][27][28][29][30][31][32][33][34] and the highest among critically ill patients, reaching up to 66% [35,36] (Table 2).…”

Section: Incidencementioning

confidence: 99%

Acute kidney injury in HIV‐infected patients: a critical review

et al. 2018

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Acute kidney injury (AKI) is characterized by a rapid decline of renal function associated with worse outcomes. The purpose of the authors is to perform a critical review of the incidence, risk factors, pathogenesis and outcome of AKI in HIV‐infected patients. Human immunodeficiency virus (HIV)‐infected patients have an increased risk of developing AKI, to which contribute both HIV‐dependent and HIV‐independent factors as well as the nephrotoxicity of drugs used. The increased risk of AKI in HIV‐infected patients and its negative impact on prognosis highlights the need for identification of patients at risk, creation of prevention strategies and management. HIV‐infected patients have an increased risk of developing AKI, to which both HIV‐dependent and HIV‐independent factors contribute, as well as the nephrotoxicity of drugs used. The increased risk of AKI in HIV‐infected patients and its negative impact on prognosis highlight the need for identification of patients at risk, creation of prevention strategies and management.

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Acute kidney injury in AIDS: frequency, RIFLE classification and outcome

Cited by 9 publications

References 30 publications

Platelet Function in Acute Kidney Injury: A Systematic Review and a Cohort Study

Platelet Function in Acute Kidney Injury: A Systematic Review and a Cohort Study

Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review)

Acute kidney injury in HIV‐infected patients: a critical review

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