Acute Kidney Injury in Adults With Hemophagocytic Lymphohistiocytosis

Aulagnon, Florence; Lapidus, Nathanaël; Canet, Emmanuel; Galicier, Lionel; Boutboul, David; Péraldi, Marie-Noëlle; Reuter, Danielle; Bernard, R; Schlemmer, Benoı̂t; Azoulay, Élie; Zafrani, Lara

doi:10.1053/j.ajkd.2014.10.012

Cited by 85 publications

(78 citation statements)

References 40 publications

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“…The most frequent among them are described in this section and other potential causes are listed in Table 2 [32,[37][38][39][40][41][42][43][44][45][46][47][48][49].…”

Section: Underlying Causes Of Acute Kidney Injurymentioning

confidence: 99%

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Acute kidney injury in hematological patients

Canet

Vincent

Darmon³

et al. 2015

Current Opinion in Critical Care

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“…The most frequent among them are described in this section and other potential causes are listed in Table 2 [32,[37][38][39][40][41][42][43][44][45][46][47][48][49].…”

Section: Underlying Causes Of Acute Kidney Injurymentioning

confidence: 99%

“…Hemophagocytic lymphohistiocytosis [2,39] T-cell and B-cell lymphomas, Hodgkin lymphomas and Castleman's disease.…”

Section: -5%mentioning

confidence: 99%

Acute kidney injury in hematological patients

Canet

Vincent

Darmon³

et al. 2015

Current Opinion in Critical Care

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“…9 The spectrum of AKI is similar in patients with secondary HLH. 11 It is considered a strong predictor of poor outcomes. Acute tubular necrosis associated with interstitial inflammation is the most frequent renal histopathologic finding seen in 45% of patients with HLH.…”

Section: Discussionmentioning

confidence: 99%

Direct Reversible Kidney Injury in Familial Hemophagocytic Lymphohistiocytosis Type 3

Malaga-Dieguez¹,

Wu²,

Trachtman³

2015

Journal of the American Society of Nephrology

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Hemophagocytic lymphohistiocytosis is a hyperinflammatory disorder resulting from primary or secondary immune dysfunction. AKI is frequent in severe hemophagocytic lymphohistiocytosis and has been attributed to multiorgan failure or the use of nephrotoxic drugs, but AKI is rarely considered a direct consequence of the disease process. We describe a child with familial hemophagocytic lymphohistiocytosis type 3 who developed AKI requiring prolonged renal replacement therapy because of severe renal inflammation. There was massive infiltration of the renal parenchyma by activated macrophages and cytotoxic T cells, and acute tubular injury. The patient responded to high-dose intravenous methylprednisolone, which resulted in improvement of renal function and discontinuation of renal replacement therapy. This case confirms the occurrence of reversible AKI due to hemophagocytic lymphohistiocytosis-induced activated macrophage infiltration of the renal parenchyma and inflammation.

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“…A large recent French study of 95 patients with secondary HS disclosed AKI in 62%, whereof 59% needed RRT and 24% had nephrotic-range proteinuria [7]. Massive, often nephrotic-range proteinuria is likewise an initial, but transient symptom in NE (and probably in all other HTVF forms as well), and always precedes the AKI episode by a few days.…”

mentioning

confidence: 99%

“…A feverish AKI case without early thrombocytopenia and proteinuria is probably no NE case [2]. Of note, most described MODS complications in HS survivors were rapidly and completely reversible, leaving apparently no sequelae [5][6][7]. The same is true for all hantaviral M A N U S C R I P T…”

mentioning

confidence: 99%