Acute kidney injury following multiple wasp stings

Nandi, Madhumita; Sarkar, Sumantra

doi:10.1007/s00467-012-2250-5

Cited by 18 publications

(12 citation statements)

References 9 publications

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“…It is reported that ATIN following bee and wasp stings is reported to have a favourable response to corticosteroid therapy 5–11. On the other hand, Nandi and Sarkar reported complete resolution of renal failure in a child with ATIN and dialysis requiring renal failure without any immunosuppressive therapy 13. The partial renal recovery in the first patient was secondary to pre-existing chronic parenchymal disease.…”

Section: Discussionmentioning

confidence: 97%

Acute tubulointerstitial nephritis following hymenopteran stings

Ezhilnilavan

Priyamvada

Srinivas

et al. 2018

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 97%

Acute tubulointerstitial nephritis following hymenopteran stings

Ezhilnilavan

Priyamvada

Srinivas

et al. 2018

Postgraduate Medical Journal

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“…Bee venom, which has as its main components hyaluronidase, phospholipase A2, melitin and apamin, contributes to renal damage due to synergistic toxic and hypotensive effects 1,11 . Moreover, these substances can induce the release of several other mediators, such as histamine, serotonin, bradykinin and prostaglandin.…”

Section: Physiopathology Of Kidney Injurymentioning

confidence: 99%

“…Other signs and symptoms resulting from the toxic effects of bee venom are nausea, vomiting, hyperventilation (acid breathing), generalized edema, myalgia, arthralgia, headache, restlessness and consciousness alteration. At the time of hospital admission some patients present stupor, a semi-comatose status, often suffering from severe respiratory failure 3-6,10,11,15,16,18 . The severity of AKI seems to be associated with the number of stings, since creatinine levels were higher, in most cases, when there were more than 1,000 stings 3-5 .…”

Section: Clinical Characteristics and Laboratory Abnormalitiesmentioning

confidence: 99%

Acute kidney injury complicating bee stings – a review

Silva

Vasconcelos

Rocha

et al. 2017

Rev. Inst. Med. trop. S. Paulo

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Bee stings can cause severe reactions and have caused many victims in the last years. Allergic reactions can be triggered by a single sting and the greater the number of stings, the worse the prognosis. The poisoning effects can be systemic and can eventually cause death. The poison components are melitin, apamin, peptide 401, phospholipase A2, hyaluronidase, histamine, dopamine, and norepinephrine, with melitin being the main lethal component. Acute kidney injury (AKI) can be observed in patients suffering from bee stings and this is due to multiple factors, such as intravascular hemolysis, rhabdomyolysis, hypotension and direct toxicity of the venom components to the renal tubules. Arterial hypotension plays an important role in this type of AKI, leading to ischemic renal lesion. The most commonly identified biopsy finding in these cases is acute tubular necrosis, which can occur due to both, ischemic injury and the nephrotoxicity of venom components. Hemolysis and rhabdomyolysis reported in many cases in the literature, were demonstrated by elevated serum levels of indirect bilirubin and creatine kinase. The severity of AKI seems to be associated with the number of stings, since creatinine levels were higher, in most cases, when there were more than 1,000 stings. The aim of this study is to present an updated review of AKI associated with bee stings, including the currently advised clinical approach.

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“…A large case series from Vietnam has reported 16.3% of refractory hypotension and 6/43 (14%) of deaths after hornet sting allergic patients (n = 43) [8]. Fatalities due to anaphylaxis following V. affinis stings have been reported in Sri Lanka [11–13] and South East Asia [2, 14–17] Several case reports of V. affinis allergy and envenomation have also been reported from India [18–20], Nepal [21, 22] and Bangladesh [23, 24].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Vespa affinis venom allergy: use of immunochemical methods and a passive basophil activation test

Gunasekara

Handunnetti

Premawansa

et al. 2019

Allergy Asthma Clin Immunol

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BackgroundAllergy to Vespa affinis venom is common in the Asia Pacific region. Venom preparations for diagnosis are not commercially available for this species.MethodsThe prominent allergens in V. affinis venom were identifiedusing immunochemical methods. Use of ImmunoCAP of Vespula vulgaris crude venom/its components and a passive basophil activation test (BAT) in the diagnosis of patients who had anaphylaxis to V. affinis venom (n = 30) were also accessed. The IgE double-positivity rates (positive to both hornet and honeybee) in ImmunoCAP and the passive BAT were determined.ResultsHigh IgE reactivity was seen with the five allergens in V. affinis venom; 96% (29/30) for 34 and 24 kDa, 93% (28/30) for 45 kDa and 90% (27/30) reactivity for the 100 and 80 kDa respectively. IgE cross-reactivity was low with ImmunoCAP using V. vulgaris venom (43%; 13/30) and Ves v1 (3%; 1/30), but relatively high with Ves v5 (73%; 22/30). All patients (100%) were positive to V. affinis venom in passive BAT. In ImmunoCAP, a high double-positivity rate (76%; 23/30) was detected while no double-positivity was detected in passive BAT.ConclusionsHigh IgE reactivity for five allergens of V. affinis points to the potential of using these allergens in component resolved diagnosis (CRD). The passive BAT has shown its importance as a promising diagnostic tool with high accuracy. It would be particularly useful in cases with doubtful double-positive results of other diagnostic tests.

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Acute kidney injury following multiple wasp stings

Cited by 18 publications

References 9 publications

Acute tubulointerstitial nephritis following hymenopteran stings

Acute tubulointerstitial nephritis following hymenopteran stings

Acute kidney injury complicating bee stings – a review

Diagnosis of Vespa affinis venom allergy: use of immunochemical methods and a passive basophil activation test

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