Acute Kidney Injury Due to Rhabdomyolysis in Narcotic Drug Users

Kosmadakis, George; Michail, Otho; Filiopoulos, V.; Papadopoulou, Panoraia; Michail, S

doi:10.5301/ijao.2011.8509

Cited by 16 publications

(14 citation statements)

References 17 publications

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“…Also the addiction of nicotine suggested to reduce the activity of G6PDH enzyme in the liver (34) . The LDH measurements have been estimated by (35) in heroin users and it was significantly higher than non-users. …”

Section: Resultsmentioning

confidence: 99%

Evaluation of Oxidative Markers, Apoptosis and Reproductive Efficiency in Heroin Addicted Rats

Othman¹

2013

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Section: Resultsmentioning

confidence: 99%

Evaluation of Oxidative Markers, Apoptosis and Reproductive Efficiency in Heroin Addicted Rats

Othman¹

2013

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“…A large series of 475 patients with rhabdomyolysis included 163 (35%) cases caused by illicit drugs and/or alcohol 4 . In addition to acute and chronic alcohol intoxication 29–31 , there are reports of rhabdomyolysis induced by heroin 32 , cocaine 33–35 , and methamphetamine 36, 37 . Ecstasy (3,4-methylenedioxy-methamphetamine) 38 and LSD (lysergic acid diethylamide) 39–41 have been associated with acute-onset rhabdomyolysis in the setting of hyperthermia and muscle rigidity.…”

Section: Acquired Causes Of Rhabdomyolysismentioning

confidence: 99%

Diagnostic evaluation of rhabdomyolysis

2015

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Rhabdomyolysis is characterized by severe acute muscle injury resulting in muscle pain, weakness, and/or swelling with release of myofiber contents into the bloodstream. Symptoms develop over hours to days following an inciting factor and may be associated with dark pigmentation of the urine. Serum creatine kinase and urine myoglobin levels are markedly elevated. The clinical examination, history, laboratory studies, muscle biopsy, and genetic testing are useful tools for diagnosis of rhabdomyolysis, and they can help differentiate acquired from inherited causes of rhabdomyolysis. Acquired causes include substance abuse, medication or toxic exposures, electrolyte abnormalities, endocrine disturbance, and autoimmune myopathies. Inherited predisposition to rhabdomyolysis can occur with disorders of glycogen metabolism, fatty acid beta-oxidation, and mitochondrial oxidative phosphorylation. Less common inherited causes of rhabdomyolysis include structural myopathies, channelopathies, and sickle cell disease. This review focuses on the differentiation of acquired and inherited causes of rhabdomyolysis and proposes a practical diagnostic algorithm.

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“…Les tableaux de rhabdomyolyse observé s chez les consommateurs de SPA peuvent être particuliè rement sé vè res [17]. Si elle en est le mé canisme le plus fré quent, la rhabdomyolyse n'est cependant pas seule responsable de NTA chez les utilisateurs de SPA.…”

Section: Rhabdomyolyse Et Tubulopathies : Cocaïne He´roïne Amphe´taunclassified

Effets uro-néphrologiques des produits utilisés par les usagers de drogues : revue de la littérature et enquête pharmaco-épidémiologique en France et dans la région de Marseille

Gully

Frauger²,

Spadari³

et al. 2017

Néphrologie & Thérapeutique

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A great diversification of drugs of abuse has been observed in recent years, both in the populations using them and in the types of drugs. Although dependency and psychiatric disorders associated with the abuse of these substances is well known, somatic complications, uro-nephrotoxicity in particular, are less recognized. We propose here an overview of the products used by drugs abusers in France, through the analysis of the national pharmaco-epidemiological study Observation des produits psychotropes illicites ou détournés de leur utilisation médicamenteuse (OPPIDUM). Among the 5003 patients who participated in this survey, 84% were on prescribed psychoactive substances, with indicators of abuse in 28% of cases; more than half of these patients had also been using drugs of abuse (mainly cannabis) in the previous week. We then describe the main urological and renal toxicities of these drugs, in particular of heroin, cocaine, cannabis, ecstasy, LSD, amphetamine, new designer drugs, ketamine and opiate substitution treatment. We finally present a pharmaco-epidemiological survey of patients hospitalized for drugs complications in nephrology at the university hospital of Marseille. Between 2000 and 2015, 22 patients aged 18 to 57 years were hospitalized for renal adverse effects of drugs of abuse, such as glomerulonephritides, focal segmental glomerulosclerosis, acute kidney injury or chronic kidney disease. The somatic complications of drugs participate in their dangerousness and should be a red flag. They should be systematically reported to the addictovigilance national network to allow the improvement of information given to the patients and the medical community, and to adapt the prevention and risk reduction policies.

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Acute Kidney Injury Due to Rhabdomyolysis in Narcotic Drug Users

Abstract: The results of this study suggest that both RM and ARF are more severe in HU than in NHU possibly due to an additional myotoxic effect of heroin.

Cited by 16 publications

References 17 publications

Evaluation of Oxidative Markers, Apoptosis and Reproductive Efficiency in Heroin Addicted Rats

Evaluation of Oxidative Markers, Apoptosis and Reproductive Efficiency in Heroin Addicted Rats

Diagnostic evaluation of rhabdomyolysis

Effets uro-néphrologiques des produits utilisés par les usagers de drogues : revue de la littérature et enquête pharmaco-épidémiologique en France et dans la région de Marseille

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