Acute Kidney Injury due to Rhabdomyolysis in H1N1 Influenza Infection

Unverdi, Selman; Akay, Hatice; Çeri, Mevlüt; İnal, Salih; Altay, Mustafa; Demiröz, Ali Pekcan; Duranay, Murat

doi:10.3109/0886022x.2011.565137

Cited by 12 publications

(11 citation statements)

References 11 publications

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“…There have been approximately 27 reported cases of rhabdomyolysis in the setting of influenza infection, although this likely represents a small fraction of the total cases as myositis and/or rhabdomyolysis have infrequently been reported prior to the 2009 A(H1N1) pandemic (Table ) . Among 18 patients in Mexico with influenza A(H1N1)pdm09 infection, 62% of patients had mild‐to‐moderate elevations of creatinine kinase (CK) .…”

Section: Resultsmentioning

confidence: 99%

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Sellers

Hagan

Hayden

et al. 2017

Influenza Resp Viruses

326

308

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Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra‐pulmonary complications of influenza infection, using organ‐specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra‐pulmonary complications is critical to determining the true burden of influenza infection and initiating organ‐specific supportive care.

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Section: Resultsmentioning

confidence: 99%

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Sellers

Hagan

Hayden

et al. 2017

Influenza Resp Viruses

326

308

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“…Elevated creatine kinase (CK) has been implicated as a contributing factor for AKI in pH1N1 [14,17,22,28]. Pettila et al reported that 15.8% of AKI patients had CK levels exceeding 5000 IU/L and found a trend of increasing CK levels with worsening AKI [26].…”

Section: Discussionmentioning

confidence: 99%

“…AKI commonly accompanies critical illness and independently increases risks of death, prolonged length of stay, and development of new chronic kidney disease (CKD) among survivors [11,12]. Recently, reports have described the incidence and outcomes of AKI among critically ill adult and pediatric pH1N1 patients [13]–[28]. Many studies, however, were limited by design (case reports [14,17,20,22,24,28] or small case series [13,15,18,21,27]), small sample size [16,19,25], or single-center enrollment [13,15,16,18,21].…”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study

et al. 2013

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BackgroundCanada’s pandemic H1N1 influenza A (pH1N1) outbreak led to a high burden of critical illness. Our objective was to describe the incidence of AKI (acute kidney injury) in these patients and risk factors for AKI, renal replacement therapy (RRT), and mortality.MethodsFrom a prospective cohort of critically ill adults with confirmed or probable pH1N1 (16 April 2009–12 April 2010), we abstracted data on demographics, co-morbidities, acute physiology, AKI (defined by RIFLE criteria for Injury or Failure), treatments in the intensive care unit, and clinical outcomes. Univariable and multivariable logistic regression analyses were used to evaluate the associations between clinical characteristics and the outcomes of AKI, RRT, and hospital mortality.ResultsWe included 562 patients with pH1N1-related critical illness (479 [85.2%] confirmed, 83 [14.8%] probable]: mean age 48.0 years, 53.4% female, and 13.3% aboriginal. Common co-morbidities included obesity, diabetes, and chronic obstructive pulmonary disease. AKI occurred in 60.9%, with RIFLE categories of Injury (23.0%) and Failure (37.9%). Independent predictors of AKI included obesity (OR 2.94; 95%CI, 1.75-4.91), chronic kidney disease (OR 4.50; 95%CI, 1.46-13.82), APACHE II score (OR per 1-unit increase 1.06; 95%CI, 1.03-1.09), and PaO2/FiO2 ratio (OR per 10-unit increase 0.98; 95%CI, 0.95-1.00). Of patients with AKI, 24.9% (85/342) received RRT and 25.8% (85/329) died. Independent predictors of RRT were obesity (OR 2.25; 95% CI, 1.14-4.44), day 1 mechanical ventilation (OR 4.09; 95% CI, 1.21-13.84), APACHE II score (OR per 1-unit increase 1.07; 95% CI, 1.03-1.12), and day 1 creatinine (OR per 10 μmol/L increase, 1.06; 95%CI, 1.03-1.10). Development of AKI was not independently associated with hospital mortality.ConclusionThe incidence of AKI and RRT utilization were high among Canadian patients with critical illness due to pH1N1.

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“…However, many clinicians may fail to recognize rhabdomyolysis as an important complication associated with influenza A/H1N1 2009. Recently, several adult cases of severe rhabdomyolysis and acute renal failure associated with influenza A/H1N1 2009 were reported 2–4 . We report herein a pediatric case involving rhabdomyolysis and compartment syndrome associated with influenza A/H1N1 2009.…”

mentioning

confidence: 84%

“…Recently, several adult cases of severe rhabdomyolysis and acute renal failure associated with influenza A/H1N1 2009 were reported. [2][3][4] We report herein a pediatric case involving rhabdomyolysis and compartment syndrome associated with influenza A/H1N1 2009.…”

mentioning

confidence: 98%

Rhabdomyolysis associated with influenza A/H1N1 2009 infection in a pediatric patient

Ishiwada

Takada

Okunushi

et al. 2012

Pediatrics International

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The influenza A/H1N1 2009 epidemic has spread to many countries since 2009, including Japan. We report an immune-competent child involving rhabdomyolysis and compartment syndrome associated with influenza A/H1N1 2009. The patient was demonstrated rhabdomyolysis with myoglobinuria, hyperkalemia, cardiac dysfunction and compartment syndrome that arose during convalescence from influenza A/H1N1 2009 infection. Although RT-PCR of muscle tissue yielded negative results for influenza A/H1N1 2009 RNA and no viral positive-antigen cells were detected in the muscle lesions, the clinical picture suggested rhabdomyolysis associated with influenza A/H1N1. Rhabdomyolysis should be considered in the evaluation of muscle symptoms such as myalgia associated with novel influenza A/H1N1 2009 virus infection, particularly in critically ill patients.

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Acute Kidney Injury due to Rhabdomyolysis in H1N1 Influenza Infection

Cited by 12 publications

References 11 publications

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection

Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study

Rhabdomyolysis associated with influenza A/H1N1 2009 infection in a pediatric patient

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