Acute Kidney Injury by SARS-CoV-2 virus in patients with COVID-19: an integrative review

Abstract

Objective: to assess scientific evidence on SARS-CoV-2 Acute Kidney Injury in patients with COVID-19. Methods: an integrative review, with adoption of PICO strategy and classification of the level of evidence, carried out on April 10, 2020 in the PubMed database, of articles available between December 2019 and April 2020. Results: the sample consisted of six original, five observational and one experimental articles. Observational studies addressed the clinical findings of patients with COVID-19 and association between kidney damage, infection, and morbidity-mortality. Conclusion: the studies addressed the mechanism of intracellular infection of SARS-CoV-2, its cytopathic effects on kidney cells and incidence of acute kidney injury in patients infected with SARS-CoV-2. Acute kidney injury is associated with increased mortality and morbidity in these patients. This review realizes the need for new research that can mention kidney care to patients with COVID-19.

Interactions amongst inflammation, renin-angiotensin-aldosterone and kallikrein-kinin systems: suggestive approaches for COVID-19 therapy

“…In addition to the occurrence of acute injury and loss of renal function, chronic damage to the cardiovascular system is an important clinical complication of viral infection and is associated with increased rates of mortality and morbidity in these patients [ 65 , 66 ]. Manifestations of COVID-19 include other organs with symptoms at the digestive tract, sensory perceptions and at the central nervous system.…”

Pathophysiology and Clinical Manifestations of COVID-19-Related Acute Kidney Injury—The Current State of Knowledge and Future Perspectives

“…The duration, as well as the recovery rates of COVID-19 AKI patients, remains unknown [133]. However, the presence of COVID-induced AKI in hospitalized patients is significantly associated with worse clinical outcomes and higher mortality rates compared to those of patients without this complication [99,118,119,[134][135][136][137][138]. Furthermore, AKI related to SARS-CoV-2 infection is associated with greater mortality rates compared to those of AKI induced by other causes, and its prevalence increases with the severity of infection [129,134,139,140].…”

Lesão renal aguda na COVID-19 e abordagem multiprofissional

“…Pesquisas sugerem que o aumento de alguns parâmetros renais, como proteinúria, hematúria, ureia e creatinina sérica (SCr) se associam a mortalidade até cinco vezes maior neste grupo (Cheng et al, 2020;Li et al, 2020b;Moitinho et al, 2020). afirmam que os podócitos são particularmente vulneráveis a ataques virais e bacterianos, e o dano aos podócitos induz facilmente proteinúria intensa.…”