Acute kidney injury associated with COVID-19: another extrapulmonary manifestation

Camargo, Luis Barros; Marzola, Iván Darío Quintero; Gómez, Juan Carlos Cárdenas; Daza, Leidy Tatiana Mendoza; Pájaro, Loraine Quintana

doi:10.1007/s11255-020-02507-w

Cited by 6 publications

(4 citation statements)

References 14 publications

(15 reference statements)

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“…Initial reports from Wuhan suggested that AKI is not associated with COVID-19 [1]. As the disease case load increased, reports of AKI started to emerge [2] early during the pandemic. Clinical features [3][4][5][6][7] and pathophysiology of kidney involvement due to COVID-19 were studied and reported [7,8].…”

Section: Discussionmentioning

confidence: 99%

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Incidence and Outcome of Acute Kidney Injury in Patients Hospitalized With Coronavirus Disease-19 at a Tertiary Care Medical Center in Saudi Arabia

Farooqui¹,

Almegren²,

Binrushud³

et al. 2021

Cureus

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The systemic acute respiratory syndrome coronavirus (SARS-CoV-2) has been associated with acute kidney injury (AKI). We retrospectively studied the incidence and outcome of AKI in patients hospitalized with COVID-19 at King Abdulaziz Medical City (KAMC) Riyadh, Kingdom of Saudi Arabia. MethodsA retrospective cohort study was conducted after ethical approval from the institutional review board of King Abdullah International Medical Research Center (KAIMRC). Subjects were identified by Data Management Office of KAIMRC. The data were extracted from electronic medical records using a customized data collection sheet.The study included all adult patients (>18 years) who tested positive for COVID-19 by polymerase chain reaction and were admitted at KAMC from March 2020 until the end of September 2020. Patients with a history of end-stage kidney diseases and patients where adequate data were not available to establish diagnosis of AKI were excluded.Patient demographics, comorbid conditions, medications, use of mechanical ventilation, and 30-day mortality were recorded.

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Section: Discussionmentioning

confidence: 99%

“…Two distinctive phenotypes of AKI, AKI-early and AKI-late, have been suggested. These two types are reported to have difference in outcome [ 2 ]. In early stages, fever and diarrhea often result in dehydration.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Outcome of Acute Kidney Injury in Patients Hospitalized With Coronavirus Disease-19 at a Tertiary Care Medical Center in Saudi Arabia

Farooqui¹,

Almegren²,

Binrushud³

et al. 2021

Cureus

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“… 15 Other possible associated mechanisms of liver and kidney damage include the inflammatory cytokine storm, 1 , 5 , 16–18 drug-induced injury, 14 , 19–23 chronic liver and kidney disease 24–27 and other factors, such as hemodynamic changes. 28 , 29 …”

Section: Introductionmentioning

confidence: 99%

Abnormal Indexes of Liver and Kidney Injury Markers Predict Severity in COVID-19 Patients

Qu¹,

Zhu²,

Huang³

et al. 2021

IDR

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Background SARS-CoV-2 can damage not only the lungs but also the liver and kidney. Most critically ill patients with coronavirus disease 2019 (COVID-19) have liver and kidney dysfunction. We aim to investigate the levels of liver and kidney function indexes in mild and severe COVID-19 patients and their capability to predict the severity of the disease. Methods The characteristics and laboratory indexes were compared between patients with different conditions. We applied binary logistic regression to find the independent risk factors of severe patients. Receiver operating characteristic (ROC) analysis was used to predict the severity of COVID-19 using the liver and kidney function indexes. Results This study enrolled 266 COVID-19 patients, including 235 mild patients and 31 severe patients. Compared with mild patients, severe patients had lower albumin (ALB) and higher alanine aminotransferase (ALT), aspartate aminotransferase (AST), and urea nitrogen (BUN) (all p<0.001). Binary logistic regression analysis also identified ALB [OR=0.273 (0.079–0.947), p=0.041] and ALT [OR=2.680 (1.036–6.934), p=0.042] as independent factors of severe COVID-19 patients. Combining ALB, ALT, BUN, and LDH exhibited the area under ROC at 0.914, with a sensitivity of 86.7% and specificity of 83.0%. Conclusion COVID-19 patients, especially severe patients, have damage to liver and kidney function. ALT, AST, LDH, and BUN could be independent factors for predicting the severity of COVID-19. Combining the ALB, ALT, BUN, and LDH could predict the transition from mild to severe in COVID-19 patients.

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“…Further studies have demonstrated that this virus can also damage the liver [6][7][8][9][10] and kidneys [11][12][13][14], since ACE2 is also expressed in both organs [15]. Other possible associated mechanisms of liver and kidney damage include the inflammatory cytokine storm [1,5,[16][17][18], drug-induced injury [14,[19][20][21][22][23], chronic liver and kidney disease [24][25][26][27] and other factors such as hemodynamic changes [28,29].…”

Section: Introductionmentioning

confidence: 99%

Kidney and Liver Predictors of Adults Hospitalized with COVID-19 Infection

Boulos,

Sbeit,

Basheer

et al. 2024

COVID

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SARS-CoV-2 damages not only the lungs, but also the liver and kidney. Most critically ill COVID-19 patients have liver and kidney dysfunctions. The early identification of patients with COVID-19 who will develop severe or critical disease symptoms is important for delivering proper and early treatment. This research studies the correlation of liver and kidney function indexes and COVID-19 outcomes. Electronic medical record data from 391 patients diagnosed with COVID-19 in the COVID-19 Department, Galilee Medical Center, Nahariya, Israel were collected. Epidemiological, clinical, laboratory, and imaging variables were analyzed. The liver and kidney enzyme indexes were measured upon admission and discharge. A correlation between laboratory levels and severity and mortality of COVID-19 patients was undertaken. This study included 391 COVID-19 patients, 258 mild patients and 133 severe patients. Multivariate stepwise regression analyses and discriminant analyses were used to identify and validate powerful predictors. The main outcome was death or invasive ventilation. Three factors, namely higher urea nitrogen (BUN) and IL-6, and lower albumin levels, were the most powerful predictors of mortality, and classified the results (survival vs. death) correctly in 85% of cases (diagnostic accuracy) with a sensitivity of 88% and a specificity 55%. Compared with mild patients, severe patients had lower albumin (ALB), higher alanine aminotransferase (ALT), aspartate aminotransferase (AST) and BUN (all p < 0.001). COVID-19 patients, especially severe patients, have damage to liver and kidney function. BUN, IL-6 and albumin are factors predicting mortality while fibrinogen and AST could be independent factors for predicting the severity of COVID-19.

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Acute kidney injury associated with COVID-19: another extrapulmonary manifestation

Cited by 6 publications

References 14 publications

Incidence and Outcome of Acute Kidney Injury in Patients Hospitalized With Coronavirus Disease-19 at a Tertiary Care Medical Center in Saudi Arabia

Incidence and Outcome of Acute Kidney Injury in Patients Hospitalized With Coronavirus Disease-19 at a Tertiary Care Medical Center in Saudi Arabia

Abnormal Indexes of Liver and Kidney Injury Markers Predict Severity in COVID-19 Patients

Kidney and Liver Predictors of Adults Hospitalized with COVID-19 Infection

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