Acute kidney injury associated with metformin

Extracorporeal Treatment for Metformin Poisoning

“…Mortality rates were similar in both groups despite the dialysis group being sicker (higher Simplified Acute Physiology Score II, lower arterial bicarbonate, and higher creatinine concentration) and trended to have greater baseline comorbidities (higher Charlson Index). Pooled analysis of other uncontrolled descriptive cohorts did not permit individual data extraction but included 463 patients with MALA, 219 of whom received ECTR, and 72 deaths (mortality, 15.6%) (17,21,27,30,58,59,62,63). Nevertheless, the similarity in clinical outcome despite the presence of confounding-by-indication may suggest a potential benefit from hemodialysis (215).…”

Mortality rate in so-called “metformin-associated lactic acidosis”: a review of the data since the 1960s

“…We identified 12 literature series published between 1994 and 2013 . The earliest series covered a period running from the 1960s onwards .…”

A Case Report of Metformin Related Lactic Acidosis

“…In a study by Wills et al the incidence of metformin-induced severe lactic acidosis was reported to be 9.1% in patients who received a single over dose of metformin (9). In another study conducted by Li Cavoli et al among 1014 renal patients, it was reported that acute renal failure accompanied by lactic acidosis was detected in 47 patients who used metformin for hyperglycemia control (10). In another case of metformin intoxication reported by Mustafa et al, acute renal failure with lactic acidosis and hypothermia was reported (11).…”