Acute kidney injury and rhabdomyolysis due to multiple wasp stings

Radhakrishnan, Hema

doi:10.4103/0972-5229.136079

Cited by 17 publications

(12 citation statements)

References 8 publications

(8 reference statements)

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“…The mast cell secretory products, histamine and eosinophil chemotactic factor of AS, are both strong chemotactic factors for eosinophils [21], leading to heavy infiltration of eosinophils into the lung, small bowel and spleen, as we have observed (Figure 3). The prominent perivascular edema of AS in our rat model may reflect the release of histamine and other vasoactive peptides that can increase vascular permeability, as noted previously [12,13,14,18,19,20,21,22,23,24].…”

Section: Discussionsupporting

confidence: 67%

Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model

et al. 2019

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Anaphylactic shock (AS) is a life-threatening, multisystem disorder arising from sudden release of mast cell- and basophil-derived mediators into the circulation. In this study, we have used a Wistar rat model to investigate AS-associated histopathologic changes in various organs. Rats were sensitized with ovalbumin (1 mg s.c), and AS was induced by intravenous injection of ovalbumin (1 mg). Experimental groups included nonallergic rats (n = 6) and allergic rats (n = 6). Heart rate and blood pressure were monitored during one hour. Organs were harvested at the end of the experiment and prepared for histologic and immunohistochemical studies. Lung, small bowel mucosa and spleen were found to undergo heavy infiltration by mast cells and eosinophils, with less prominent mast cell infiltration of cardiac tissue. The mast cells in lung, small bowel and spleen exhibited increased expression of tryptase, c-kit and induced nitric oxide synthase (iNOS). Increased expression of endothelial nitric oxide synthase (eNOS) by vascular endothelial cells was noted principally in lung, heart and small bowel wall. The Wistar rat model of AS exhibited accumulation of mast cells and eosinophils in the lung, small bowel, and spleen to a greater extent than in the heart. We conclude that lung and gut are principal inflammatory targets in AS, and likely contribute to the severe hypotension of AS. Targeting nitric oxide (NO) production may help reduce AS mortality.

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Section: Discussionsupporting

confidence: 67%

Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model

et al. 2019

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“…This arthropod belongs to the Mutillidae family. Maybe if these individuals were stung at many times, they would face severe complications such as muscle destruction, kidney failure, and even death (52)(53)(54)(55). These complications may be seen more in children, elders, and patients whose physical strength is weak (56)(57)(58).…”

Section: Discussionmentioning

confidence: 99%

Introducing of a New Sting Agent of Velvet Ant Dentilla sp. (Hymenoptera: Mutillidae) in Kashan, Centerl of Iran (2014 - 2015)

Dehghani

Kassiri

Gharali³

et al. 2018

Arch Clin Infect Dis

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Background: Velvet ants (Mutillid wasps) are among the venomous and stinging insects, which their existence has been reported from different areas of Iran.Objectives: Since no study has been done so far in Iran in regards to their sting, their clinical complications and their sting are studied for the first time in Kashan. Methods:In this descriptive cross-sectional study that was performed during 2014 -2015, 49 individuals stung by velvet ants in the residential areas in Kashan were assessed. Identification of the sting agent was according to the morphologic specifications of the collected samples of the insect in the houses of the injured. Sting complications in the individuals were studied according to the clinical manifestation and the time of the sting, which was from June to September. Results:In this study, the sting agent was identified as velvet ants, Dentilla genus. Most sting cases were in the age group of 11 -20 years with 30.5% and the lowest belonged to the age groups of 31 -40 and 41 -50 years. The first sign of the sting was a severe and sharp pain. The highest percentage of redness in the individuals was 47% in the first day, and the lowest belonged to four or five days after the sting with 2%. Intense itching was one of the main symptoms of velvet ant stings. In the final stages of pain and itching, hemolysis and bruise signs were observed as brown spots.Conclusions: Velvet ant stings have not been reported so far from Kashan. Due to the high cases of stinging in the women carpet weaving workshops, their sitting rooms, and bed rooms, it can be concluded that this arthropod is a domestic pest. Therefore, control and prevention of its potential damages must be programmed accordingly.

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“…Insect stings can result in local allergic and severe systemic reactions, including rhabdomyolysis, renal failure, liver injury, and coagulopathy. [ 1 2 3 4 ] A range of ocular reactions such as corneal edema, conjunctivitis, cataract, and optic neuritis have been reported after insect stings. [ 1 ] These reactions were attributed to direct trauma and potential toxic effects.…”

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confidence: 99%

Exotropia in a pediatric patient with rhabdomyolysis caused by an insect sting

Kim

2017

Indian J Ophthalmol

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Various ocular and systemic reactions have been associated with insect sting. However, insect stings have been rarely reported to cause exotropia and diplopia. We encountered exotropia in a 6-year-old child with rhabdomyolysis of the left lower extremities caused by an insect sting. Exotropia and diplopia developed within 1 day after the sting and improved completely 1 week after the onset of symptoms. Clinicians should be aware of the potential for the development of exotropia in patients with insect stings, which requires careful follow-up.

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Acute kidney injury and rhabdomyolysis due to multiple wasp stings

Cited by 17 publications

References 8 publications

Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model

Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model

Introducing of a New Sting Agent of Velvet Ant Dentilla sp. (Hymenoptera: Mutillidae) in Kashan, Centerl of Iran (2014 - 2015)

Exotropia in a pediatric patient with rhabdomyolysis caused by an insect sting

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