Acute Kidney Injury and Kidney Damage in COVID-19 Patients

Na, Ki Young; Kim, Hae-Ri; Ham, Young Rok; Choi, Dae Eun; Lee, Kang Wook; Moon, Jae Young; Kim, So Hyun; Cheon, Shinhye; Sohn, Kyung Mok; Kim, Jung Ok; Kim, Sung-Min; Jeong, Hyeongseok; Jeon, Jae Wan

doi:10.3346/jkms.2020.35.e257

Cited by 28 publications

(45 citation statements)

References 24 publications

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“…Therefore, a power test was needed to achieve adequate sample size. The AKI occurred because in the clinically severe COVID-19 manifestation, several proinflammatory are being released, resulting in podocyte collapse, apoptosis, and even glomerular fibrotic (3,5,8,14).…”

Section: Discussionmentioning

confidence: 99%

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Covid-19 in children: is there any correlation with renal function and severity of the disease?

Rachmadi

Widiasta

Sukandar

et al. 2020

Preprint

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Background. Kidney manifestations are life-threatening conditions, such as end-stage renal disease (ESRD), especially when attributed to viral infections. The severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), is an emerging health problem worldwide, potentially affecting all organs, including the kidney. Most reports on kidney manifestations were conducted mostly on the adult and elderly population, and limited on children. Therefore, this study aims to analyse the correlation between kidney manifestations with the renal function of pediatric patients suffering from COVID-19. Methods. An observational analytic study was conducted in Hasan Sadikin General Hospital, Bandung, Indonesia, from March to August 2020. The demographic data, clinical signs, laboratory results, and notable kidney function were analysed, while the disease was classified as severe and nonsevere based on its clinical appearance. The Mann-Whitney test for nonparametric was used to analyze the collected data. Results. In this study, 16 COVID-19 children were selected as the research subjects, the median eGFR value in the severe group was lower (49.59 ml / minute / 1.73m2) compared to the nonsevere (113 ml / minute / 1.73m2), however, not statistically significant (p = 0.521). Significant high CRP and low thrombocyte levels were found in severe SARS-CoV-2 infection (p<0.05). Conclusion. A severe SARS-CoV-2 infection tends to affect the kidney, which is manifested as decreased glomerular filtration rate (GFR).

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Section: Discussionmentioning

confidence: 99%

“…Besides the respiratory system, the kidneys (urinary system) are the most often involved in the COVID-19 process (3,7–11). The various kidney involvement in children suffering from this disease is either mild, such as proteinuria or asymptomatic hematuria, to severe forms, such as acute kidney injury (AKI) (5,11,12).…”

Section: Introductionmentioning

confidence: 99%

Covid-19 in children: is there any correlation with renal function and severity of the disease?

Rachmadi

Widiasta

Sukandar

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Four studies were reported from the same hospital, i.e., Tongji Hospital, Wuhan, China [2,4,11,17,27]. In nine studies, one study analyzed the patients admitted in the intensive care unit (ICU) [27], and the other studies examined all hospitalized patients [1,2,4,11,17,[28][29][30]. The median age ranged from 40 to 60 years.…”

Section: Literature Reviewmentioning

confidence: 99%

“…In all studies, hematuria was observed in approximately 15-50% patients. Six studies detected hematuria using the urine dipstick test [2,4,11,27,28,30], and only two studies used urine sediment examination [1,29]. Approximately 10-60% patients had proteinuria.…”

Section: Literature Reviewmentioning

confidence: 99%

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Development of acute kidney injury with massive granular casts and microscopic hematuria in patients with COVID-19: two case presentations with literature review

et al. 2020

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Background Complications of acute kidney injury (AKI) are common in patients with coronavirus disease in 2019 (COVID-19). However, clinical characteristics of COVID-19-associated AKI are poorly described. We present two cases of severe COVID-19 patients with AKI. Case presentation A 77-year-old woman was suspected of having vancomycin-associated AKI, and a 45-year-old man was suspected of having heme pigment-induced AKI caused by rhabdomyolysis. The granular cast, which is known to be a valuable diagnostic tool for confirming the diagnosis of acute tubular necrosis, was detected in both patients at the onset of AKI. Interestingly, both patients also developed microscopic hematuria at the occurrence of AKI, and one patient had elevated d-dimer and low platelet levels simultaneously. Conclusions Some reports suggested that COVID-19-associated microangiopathy contributed to the kidney damage. Therefore, it is possible that our patients might have accompanied renal microangiopathy, and that this pathological background may have caused exaggerated tubular damage by vancomycin or heme pigment. The etiology of AKI in patients with COVID-19 is multifactorial. Superimposition of nephrotoxin(s) and virus-associate intra-renal microangiopathy may be a crucial trigger of kidney injury leading to severe AKI in COVID-19 patients. Therefore, in COVID-19 patients, risk factors for AKI should be taken into consideration to prevent its progression into severe AKI.

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Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis

Corona

Pizzocaro

Vena

et al. 2021

Rev Endocr Metab Disord

173

153

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The presence of SARS-CoV-2 was officially documented in Europe at the end of February 2020. Despite many observations, the real impact of COVID-19 in the European Union (EU), its underlying factors and their contribution to mortality and morbidity outcomes were never systematically investigated. The aim of the present work is to provide an overview and a meta-analysis of main predictors and of country differences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-associated mortality rate (MR) in hospitalized patients. Out of 3714 retrieved articles, 87 studies were considered, including 35,486 patients (mean age 60.9 ± 8.2 years) and 5867 deaths. After adjustment for confounders, diabetes mellitus was the best predictors of MR in an age- and sex-dependent manner, followed by chronic pulmonary obstructive diseases and malignancies. In both the US and Europe, MR was higher than that reported in Asia (25[20;29] % and 20[17;23] % vs. 13[10;17]%; both p < 0.02). Among clinical parameters, dyspnea, fatigue and myalgia, along with respiratory rate, emerged as the best predictors of MR. Finally, reduced lymphocyte and platelet count, along with increased D-dimer levels, all significantly contributed to increased mortality. The optimization of glucose profile along with an adequate thrombotic complications preventive strategy must become routine practice in diseased SARS-CoV-2 infected patients. Supplementary Information The online version contains supplementary material available at 10.1007/s11154-021-09630-8.

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Acute Kidney Injury and Kidney Damage in COVID-19 Patients

Cited by 28 publications

References 24 publications

Covid-19 in children: is there any correlation with renal function and severity of the disease?

Covid-19 in children: is there any correlation with renal function and severity of the disease?

Development of acute kidney injury with massive granular casts and microscopic hematuria in patients with COVID-19: two case presentations with literature review

Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis

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