Acute kidney injury: an unusual complication of posaconazole use

Otu, Akaninyene; Bongomin, Felix; Kosmidis, Chris; Denning, David W.

doi:10.1080/1120009x.2018.1522472

Cited by 5 publications

(3 citation statements)

References 12 publications

(9 reference statements)

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“…The antifungal of choice is liposomal amphotericin B, which was used in our case 4 15. Posaconazole has also shown favourable outcomes and thought to be the most favourable alternative to amphotericin B, and is less likely to cause renal toxicity 4 16…”

Section: Discussionmentioning

confidence: 88%

Saksenaeamucormycosis: a rare and dangerous cause of necrotising fasciitis

Sykes¹,

Krause²,

Lamparelli³

et al. 2023

BMJ Case Rep

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Necrotising fasciitis is a rapidly progressing soft tissue infection requiring early and adequate surgical debridement and appropriate antibiotic cover. The present case highlights bacterial fasciitis associated with fungal (Mucor) infection with insidious angioinvasive nature (Saksenaea vasiformis) which required amputation, negative-pressure vacuum dressings and amphotericin B for definitive treatment. This demonstrates a relatively rare case of the group IV classification of necrotising fasciitis, which we must consider when there is slowly progressing tissue death despite seemingly adequate treatment.

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Section: Discussionmentioning

confidence: 88%

Saksenaeamucormycosis: a rare and dangerous cause of necrotising fasciitis

Sykes¹,

Krause²,

Lamparelli³

et al. 2023

BMJ Case Rep

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“…Posaconazole has a relatively safe renal side effects profile. Only one case of AKI has been reported with posaconazole so far [9]. The histology was not shared as a renal biopsy was not performed, and the renal functions of the patient improved after stopping posaconazole.…”

Section: Discussionmentioning

confidence: 98%

“…Only one case of acute kidney injury (AKI) caused by posaconazole has been reported where a renal biopsy was not performed, and the renal function improved after stopping posaconazole [9].…”

Section: Introductionmentioning

confidence: 99%