Acute kidney injury after abdominal aortic aneurysm surgery: detailed assessment of early effects using novel markers

Kokot, M; Biolik, Grzegorz; Ziaja, Damian; T, Fojt; Cisak, Kamila I.; Antoniak, Katarzyna; Kowalewska-Twardela, Teresa; Pawlicki, Krzysztof; Ziaja, Krzysztof; Duława, Jan

doi:10.20452/pamw.1351

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…The systemic inflammation highlighted in AAD patients was also associated with an imbalance of pro-coagulant and vasoconstrictor factors including D-dimer, CFIII, s-Psel and EN-1, which are deregulated compared to controls, although we found no real differences between type A and B patients. Our findings with ICAM-1 agree with previous studies [28, 29], which reported that during the early phase of AAD deregulation of the production of soluble and intracellular forms of adhesion molecule could result in lower levels of the intracellular form, such as ICAM-1, to compensate the release of circulating mediators, as illustrated in Fig. 2.…”

Section: Discussionsupporting

confidence: 93%

A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

et al. 2017

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BackgroundMagnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Consequently Mg and Ca imbalance is associated with a high risk of endothelial dysfunction, the main process observed during acute aortic dissection (AAD); in this clinical condition, which mainly affects elderly men, smooth muscle cell alterations lead to intimal tears, creating a false new lumen in the media of the aorta. AAD patients have a high risk of mortality as a result of late diagnosis because often it is not distinguished from other cardiovascular diseases.We investigated Mg and Ca total circulating levels and the associated pro-inflammatory mediators in elderly AAD patients, to gain further information on the pathophysiology of this disorder, with a view to suggesting newer and earlier potential biomarkers of AAD.ResultsTotal circulating Mg and Ca levels were both lower in AAD patients than controls (p < 0.0001). Using Ca as cut-off, 90% of AAD patients with low Ca (<8.4 mg/dL) came into the type A classification of AAD. Stratifying AAD according to this cut-off, Mg was lower in patients with lower total Ca.Compared to controls, both type A and B AAD patients had higher levels of all the pro-coagulant and pro-inflammatory mediators analyzed, including sP-sel, D-dimer, TNF-α, IL-6, and CRP (p < 0.05). Dividing types A and B using the Stanford classification, no significant differences were found (p > 0.05) The levels of both ICAM-1 and EN-1 were lower in AAD than in a control group (p < 0.0001 and p < 0.05 respectively).ConclusionsThese findings suggest that low Mg and Ca in AAD elderly patients may contribute to altering normal endothelial physiology and also concur in changing the normal concentrations of different mediators involved in vasodilatation and constriction, associated with AAD onset and severity.

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Section: Discussionsupporting

confidence: 93%

A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

et al. 2017

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“…Cytokines in particular are easily measured and are potential biomarkers of AKI. Several serum and urinary biomarkers have been recently investigated in AKI and characterised as more sensitive indicators of AKI than serum creatinine or urea nitrogen [46][47][48][49][50][51] . An ideal renal biomarker would be easily measured, inexpensive, sensitive to detection of subclinical injury and correlate prognosis with onset and severity of injury.…”

Section: Diagnosismentioning

confidence: 99%

Acute kidney injury following acute pancreatitis: A review

Petejová¹,

Martínek²

2013

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Backround. Acute kidney injury (AKI) is a common serious complication of severe acute pancreatitis (SAP) and an important marker of morbidity and mortality in critically ill septic patients. AKI due to severe acute pancreatitis can be the result of hypoxemia, release of pancreatic amylase from the injured pancreas with impairment of renal microcirculation, decrease in renal perfusion pressure due to abdominal compartment syndrome, intraabdominal hypertension or hypovolemia. Endotoxins and reactive oxygen species (ROS) also play an important role in the pathophysiology of SAP and AKI. Knowledge of the pathophysiology and diagnosis of AKI following SAP might improve the therapeutic outcome of critically ill patients. Methods and Results. An overview of the pathophysiology, diagnosis and potential treatment options based on a literature search of clinical human and experimental studies from 1987 to 2013. Conclusions. Early recognition of AKI and SAP in order to prevent severe complication like septic shock, intraabdominal hypertension or abdominal compartment syndrome leading to multiple organ dysfunction syndrome is a crucial tool of therapeutic measures in intensive care.

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“…More specifically, as far as open AAA repair and NGAL level changes are concerned, an increase in serum NGAL (75.21±55.83 vs. 46.37±21.60 ng/ml, p>0.05) and significantly elevated plasma NGAL levels at 2 h (91.54±76.54 vs. baseline, p<0.05), 12 h (100.78±44.92 vs. baseline, p<0.05), and 24 h (89.46±94.18 vs. baseline, p<0.05) after clamp release and reperfusion were found [33,34].…”

Section: Ngal and Aaa Natural Historymentioning

confidence: 94%

“…Additionally, AAA surgery triggers an inflammatory reaction and thus the increase of NGAL, which is known to be an acute-phase reactant produced by some immune cells [33]. NGAL has further been widely studied as an individual marker of acute kidney injury (AKI) induced by the AAA repair surgery, and it has been shown to increase due to decreased GFR with subsequent clearance impairment per se [34,35].…”

Section: Ngal and Aaa Natural Historymentioning

confidence: 99%

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Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker. Does It Apply in Abdominal Aortic Aneurysms? A Review of Literature

Karaolanis

Moris²,

Palla

et al. 2014

Indian J Surg

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Neutrophil gelatinase associated lipocalin (NGAL) as a protein derived from neutrophils has recently been the field of investigation in a wide range of diseases (renal disease, coronary artery disease, etc). The MEDLINE/PubMed database was searched for publications with the medical subject heading "NGAL" and keywords "Abdominal aortic aneurysm (AAA)," "biomarker," and "growth". We restricted our search to date. In this review, we included 38 articles and abstracts that were accessible and available in English. An effort to further explain the role of NGAL within AAA has been made. NGAL seems to be a hopeful marker for the pathogenesis and the progression of abdominal aortic aneurysms (AAAs), which has significant morbidity and mortality rates.

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Acute kidney injury after abdominal aortic aneurysm surgery: detailed assessment of early effects using novel markers

Cited by 7 publications

References 19 publications

A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

Acute kidney injury following acute pancreatitis: A review

Neutrophil Gelatinase Associated Lipocalin (NGAL) as a Biomarker. Does It Apply in Abdominal Aortic Aneurysms? A Review of Literature

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