Acute kidney injury

Lines, Simon W.; Lewington, Andrew

doi:10.7861/clinmedicine.9-3-273

Cited by 9 publications

(3 citation statements)

References 20 publications

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“…AKI is a common disorder in hospitalized patients, and its incidence is increasing day by day [ 7 ] and has an important modifying effect on mortality, kidney recovery and health resource utilization [ 8 ]. AKI affects somewhere between 2% and 18% of all hospitalized patients and as many as 25%–30% of patients in the intensive care unit [ 9 ]. Kidney disease improving global outcomes (KDIGO), has defined AKI as a condition in which “increase in serum creatinine by 50% within 7 days, or increase in serum creatinine by 0.3 mg/dL within 2 days, or urine output <0.5 mL/kg/h for 6–12 h” [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection

Kana

Ganesh

Deepanjali

et al. 2021

Asian Journal of Urology

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Objective Urinary tract infection (UTI) is a common cause of morbidity and hospitalisation in the population worldwide. Upper UTI is indolent and causes subclinical acute kidney injury (AKI) resulting in preventable cause of scarring of renal parenchyma. We explored urinary and serum levels of kidney injury molecule-1 (KIM-1), haematological parameters and quantitative urine microscopy parameters to predict kidney injury. Methods Neutrophil–lymphocyte ratio (NLR) is obtained by dividing absolute neutrophil count with absolute lymphocyte count. Quantitative urine sediment microscopy was performed and correlated with clinical, biochemical and haematological findings to predict AKI in patients with UTI. Quantitative ELISA was performed for serum and urine levels of KIM-1. Seventy two adult patients with UTI were enrolled, 45 of whom had AKI while 27 were in the non-AKI group. Results NLR ( p =0.005) and renal tubular epithelial cell-granular cast score in quantitative urine microscopy ( p =0.008) are strong predictors of AKI in patients with UTI while rest of quantitative urine microscopy parameters and serum and urinary levels of KIM-1 molecule were not found to be useful in prediction of AKI. Conclusion NLR in haemogram is a novel and useful biomarker for predicting AKI in patients with UTI.

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Section: Introductionmentioning

confidence: 99%

Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection

Kana

Ganesh

Deepanjali

et al. 2021

Asian Journal of Urology

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“…AKI is a condition that commonly develops in acutely ill patients and therefore occurs across a wide range of medical and surgical specialties. 4 Unfortunately, the recognition and management of patients with AKI has been poor with only 50% of patients receiving good care as reported in the National Confidential Enquiry into Patient Outcomes and Death (NCEPOD) Adding Insult to Injury AKI study. 5 Poor recognition of AKI risk factors has further been identified in a more recent NCEPOD study Elective and Emergency Surgery in the Elderly: An Age-Old Problem.…”

Section: Introductionmentioning

confidence: 97%

Invited Manuscript Poster on Renal-Related Education American Society of Nephrology, Nov. 16–21, 2010 Do Medical Trainees Receive Adequate Training in the Management of Acute Kidney Injury?

Ali

Lewington

2011

Renal Failure

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There has been increased interest in acute kidney injury (AKI) over the past decade following the recognition of the association of relatively small rises in serum creatinine with worse patient outcomes. This association has resulted in newly proposed definitions in AKI based on changes in serum creatinine. In 2009, the National Confidential Enquiry into Patient Outcomes and Death Adding Insult to Injury AKI study reported that only 50% of patients who died with a diagnosis of AKI received good care. The study identified multiple deficiencies and made a number of recommendations which included improving the training of undergraduate and postgraduate trainees in the management of AKI. The aim of the evaluation was to try and identify the perception of medical trainees in Leeds Teaching Hospitals of the training they had received on AKI. A simple questionnaire was used and captured the views of 73 trainees (including 13 final-year medical students). The evaluation indicated that the majority of trainees were unaware of newly proposed definitions of AKI, and many trainees felt that the training they had received in AKI was inadequate for their needs. Following this evaluation, we have made a number of changes to the training that is delivered to both undergraduate and postgraduate trainees in Leeds on the management of AKI.

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“…Renal replacement therapy (RRT) is gradually into doctors' view as clinical treatment for AKI . However, there are still disputes about the best RRT dose and therapy time . Hence, the development and generation of molecular targets will be required for further prevention and therapy of AKI.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA YAP1 acts as the sponge of microRNA‐21‐5p to secure HK‐2 cells from ischaemia/reperfusion‐induced injury

Huang

Cao

Wang

et al. 2020

J Cellular Molecular Medi

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Acute kidney injury (AKI), a kind of syndrome with sudden degradation of renal function, is characterized by loss of urine creatinine. 1 With 7.0% incidence in China, AKI becomes a representative public health matter that ranges from newborns to senior citizens. 2 AKI is divided into pre-kidney, intrinsic and post-kidney, of whose pathophysiology risk factors include inflammatory diseases, 3 traumatism 4 and drug overdose. 5 In addition, ischaemia/reperfusion (I/R) during kidney transplantation also is extremely likely to elicit AKI. 6,7 I/R injury, which results from the inadequate supply of oxygen and nutrients to kidney Abstract Circular RNA YAP1 (circYAP1) was reported to participate in progression of gastric cancer. However, the role of circYAP1 in acute kidney injury (AKI) remains obscure.We attempted to examine the effects of circYAP1 on ischaemia/reperfusion-stimulated renal injury. AKI model was established by treating HK-2 cells in ischaemia/ reperfusion (I/R) environment. CircYAP1 expression in blood of AKI patients and I/Rtreated HK-2 cells was evaluated via RT-qPCR. CCK-8, flow cytometry, ELISA and ROS assay were executed to test the impact of circYAP1 on cell viability, apoptosis, inflammatory cytokines and ROS generation. Bioinformatic analysis was executed to explore miRNA targets. The relativity between circYAP1 and miR-21-5p was verified by RT-qPCR and luciferase assay. The functions of miR-21-5p in I/R-triggered injury were reassessed. PI3K/AKT/mTOR pathway was detected by Western blot. Down-regulated circYAP1 was observed in AKI blood samples and I/R-treated HK-2 cells. CircYAP1 overexpression expedited cell growth and weakened secretion of inflammatory factors and ROS generation in I/R-disposed cells. Besides, we found circYAP1 could sponge to miR-21-5p. Interestingly, miR-21-5p overexpression overturned the repressive effects of circYAP1 on cell injury. Moreover, PI3K/AKT/mTOR pathway was activated by circYAP1 via inhibiting miR-21-5p. We demonstrated that circYAP1 activated PI3K/AKT/mTOR pathway and secured HK-2 cells from I/R injury via sponging miR-21-5p. K E Y W O R D S acute kidney injury, circular RNA YAP1, ischaemia/reperfusion, microRNA-21-5p, PI3K/AKT/ mTOR pathway

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Acute kidney injury

Cited by 9 publications

References 20 publications

Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection

Urine microscopy and neutrophil–lymphocyte ratio are early predictors of acute kidney injury in patients with urinary tract infection

Invited Manuscript Poster on Renal-Related Education American Society of Nephrology, Nov. 16–21, 2010 Do Medical Trainees Receive Adequate Training in the Management of Acute Kidney Injury?

Circular RNA YAP1 acts as the sponge of microRNA‐21‐5p to secure HK‐2 cells from ischaemia/reperfusion‐induced injury

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